Efficacy and safety of intensive blood pressure control in patients over 60 years: A systematic review and meta-analysis
Objectives To evaluate the efficacy and safety of intensive blood pressure control in patients over 60 years.Methods Databases including PubMed, Embase and Cochrane library were searched from inception through February 1, 2024. Randomized controlled trials evaluating the efficacy or safety of intens...
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Taylor & Francis Group
2025-12-01
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| Series: | Clinical and Experimental Hypertension |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10641963.2025.2465399 |
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| author | Huarong Yang Haiyan Xing Xue Zou Meihua Jin Yang Li Ke Xiao Li Cai Yao Liu Xue Yang |
| author_facet | Huarong Yang Haiyan Xing Xue Zou Meihua Jin Yang Li Ke Xiao Li Cai Yao Liu Xue Yang |
| author_sort | Huarong Yang |
| collection | DOAJ |
| description | Objectives To evaluate the efficacy and safety of intensive blood pressure control in patients over 60 years.Methods Databases including PubMed, Embase and Cochrane library were searched from inception through February 1, 2024. Randomized controlled trials evaluating the efficacy or safety of intensive blood pressure control in patients over 60 years were included in the meta-analysis.Results Intensive blood pressure control in individuals with mild hypertension has been shown to reduce the risk of heart failure, stroke, myocardial infarction, major cardiovascular events, cardiovascular mortality, and all-cause mortality. The benefits of intensive blood pressure control in patients with moderate to severe hypertension are comparable to those observed in individuals with mild hypertension, with the exception of a reduced impact on all-cause mortality and cardiovascular mortality. Compared with maintaining systolic blood pressure (SBP) above 140 mmHg, SBP below 140 mmHg is associated with a decreased risk of major cardiovascular events in patients aged over 70, as well as a reduced risk of stroke in patients aged 60–69. Furthermore, compared to maintaining SBP above 130 mmHg, SBP below 130 mmHg is linked to a lower risk of major cardiovascular events, heart failure and myocardial infarction in patients over 60, a reduced risk of stroke and cardiovascular mortality in patients aged 60–69, and a decreased risk of all-cause mortality in patients over 70. However, a lower baseline blood pressure or more aggressive blood pressure control may be associated with an increased risk of hypotension.Conclusions Patients with hypertension aged over 60 years can derive benefits from intensive blood pressure management without experiencing significant adverse events, aside from hypotension. |
| format | Article |
| id | doaj-art-9da7d3015ffc4c25ae14907e37c55c64 |
| institution | OA Journals |
| issn | 1064-1963 1525-6006 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj-art-9da7d3015ffc4c25ae14907e37c55c642025-08-20T02:38:22ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062025-12-0147110.1080/10641963.2025.2465399Efficacy and safety of intensive blood pressure control in patients over 60 years: A systematic review and meta-analysisHuarong Yang0Haiyan Xing1Xue Zou2Meihua Jin3Yang Li4Ke Xiao5Li Cai6Yao Liu7Xue Yang8Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Pharmacy, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Cardiovascular Medicine, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Pharmacy, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Pharmacy, Daping Hospital, Army Medical University, Chongqing, ChinaCollege of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing, ChinaCollege of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing, ChinaDepartment of Pharmacy, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Pharmacy, Daping Hospital, Army Medical University, Chongqing, ChinaObjectives To evaluate the efficacy and safety of intensive blood pressure control in patients over 60 years.Methods Databases including PubMed, Embase and Cochrane library were searched from inception through February 1, 2024. Randomized controlled trials evaluating the efficacy or safety of intensive blood pressure control in patients over 60 years were included in the meta-analysis.Results Intensive blood pressure control in individuals with mild hypertension has been shown to reduce the risk of heart failure, stroke, myocardial infarction, major cardiovascular events, cardiovascular mortality, and all-cause mortality. The benefits of intensive blood pressure control in patients with moderate to severe hypertension are comparable to those observed in individuals with mild hypertension, with the exception of a reduced impact on all-cause mortality and cardiovascular mortality. Compared with maintaining systolic blood pressure (SBP) above 140 mmHg, SBP below 140 mmHg is associated with a decreased risk of major cardiovascular events in patients aged over 70, as well as a reduced risk of stroke in patients aged 60–69. Furthermore, compared to maintaining SBP above 130 mmHg, SBP below 130 mmHg is linked to a lower risk of major cardiovascular events, heart failure and myocardial infarction in patients over 60, a reduced risk of stroke and cardiovascular mortality in patients aged 60–69, and a decreased risk of all-cause mortality in patients over 70. However, a lower baseline blood pressure or more aggressive blood pressure control may be associated with an increased risk of hypotension.Conclusions Patients with hypertension aged over 60 years can derive benefits from intensive blood pressure management without experiencing significant adverse events, aside from hypotension.https://www.tandfonline.com/doi/10.1080/10641963.2025.2465399Hypertensionagedelderlyintensive blood pressure controlmeta-analysis |
| spellingShingle | Huarong Yang Haiyan Xing Xue Zou Meihua Jin Yang Li Ke Xiao Li Cai Yao Liu Xue Yang Efficacy and safety of intensive blood pressure control in patients over 60 years: A systematic review and meta-analysis Clinical and Experimental Hypertension Hypertension aged elderly intensive blood pressure control meta-analysis |
| title | Efficacy and safety of intensive blood pressure control in patients over 60 years: A systematic review and meta-analysis |
| title_full | Efficacy and safety of intensive blood pressure control in patients over 60 years: A systematic review and meta-analysis |
| title_fullStr | Efficacy and safety of intensive blood pressure control in patients over 60 years: A systematic review and meta-analysis |
| title_full_unstemmed | Efficacy and safety of intensive blood pressure control in patients over 60 years: A systematic review and meta-analysis |
| title_short | Efficacy and safety of intensive blood pressure control in patients over 60 years: A systematic review and meta-analysis |
| title_sort | efficacy and safety of intensive blood pressure control in patients over 60 years a systematic review and meta analysis |
| topic | Hypertension aged elderly intensive blood pressure control meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/10641963.2025.2465399 |
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