Effectiveness and Immunogenicity of the MMR Vaccine Against SARS-CoV-2 Among Healthcare Workers
The purpose of this study was to evaluate the effectiveness and immunogenicity of the measles–mumps–rubella (MMR) vaccine against SARS-CoV-2 in healthcare workers at one medical institution. The effectiveness of the MMR vaccine against SARS-CoV-2 was evaluated in overall healthcare workers (HCWs). I...
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MDPI AG
2025-02-01
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| Online Access: | https://www.mdpi.com/1999-4915/17/2/215 |
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| author | Hyeri Seok Joon-Yong Bae Jooyun Kim Won Suk Choi Heedo Park Jungmin Lee Sohyun Lee Chulwoo Kim Man-Seong Park Dae Won Park |
| author_facet | Hyeri Seok Joon-Yong Bae Jooyun Kim Won Suk Choi Heedo Park Jungmin Lee Sohyun Lee Chulwoo Kim Man-Seong Park Dae Won Park |
| author_sort | Hyeri Seok |
| collection | DOAJ |
| description | The purpose of this study was to evaluate the effectiveness and immunogenicity of the measles–mumps–rubella (MMR) vaccine against SARS-CoV-2 in healthcare workers at one medical institution. The effectiveness of the MMR vaccine against SARS-CoV-2 was evaluated in overall healthcare workers (HCWs). In addition, neutralizing antibodies to SARS-CoV-2 were measured according to the subjects’ measles immunity status with serum samples collected before the coronavirus disease 2019 pandemic period. The effectiveness of the MMR vaccine for SARS-CoV-2 in all HCWs and measles IgG-positive subjects was 34% (adjusted odds ratio [aOR] = 1.20, 95% confidence interval [CI] = 0.53–2.70) and 34% (aOR = 0.66, CI = 0.38–18.4), respectively. The neutralizing antibody levels for SARS-CoV-2 were low in all groups regardless of the measles immune status. The MMR vaccine alone may not provide sufficient protection against SARS-CoV-2. |
| format | Article |
| id | doaj-art-9da52ef8511f4d9bb6096e0004a570e6 |
| institution | OA Journals |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-9da52ef8511f4d9bb6096e0004a570e62025-08-20T02:03:32ZengMDPI AGViruses1999-49152025-02-0117221510.3390/v17020215Effectiveness and Immunogenicity of the MMR Vaccine Against SARS-CoV-2 Among Healthcare WorkersHyeri Seok0Joon-Yong Bae1Jooyun Kim2Won Suk Choi3Heedo Park4Jungmin Lee5Sohyun Lee6Chulwoo Kim7Man-Seong Park8Dae Won Park9Division of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Ansan 15355, Republic of KoreaDepartment of Microbiology, Institute for Viral Diseases, Vaccine Innovation Center, Korea University Medicine, Seoul 02841, Republic of KoreaDivision of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Ansan 15355, Republic of KoreaDivision of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Ansan 15355, Republic of KoreaDepartment of Microbiology, Institute for Viral Diseases, Vaccine Innovation Center, Korea University Medicine, Seoul 02841, Republic of KoreaDepartment of Microbiology, Institute for Viral Diseases, Vaccine Innovation Center, Korea University Medicine, Seoul 02841, Republic of KoreaDepartment of Microbiology, Institute for Viral Diseases, Vaccine Innovation Center, Korea University Medicine, Seoul 02841, Republic of KoreaDepartment of Microbiology, Institute for Viral Diseases, Vaccine Innovation Center, Korea University Medicine, Seoul 02841, Republic of KoreaDepartment of Microbiology, Institute for Viral Diseases, Vaccine Innovation Center, Korea University Medicine, Seoul 02841, Republic of KoreaDivision of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Ansan 15355, Republic of KoreaThe purpose of this study was to evaluate the effectiveness and immunogenicity of the measles–mumps–rubella (MMR) vaccine against SARS-CoV-2 in healthcare workers at one medical institution. The effectiveness of the MMR vaccine against SARS-CoV-2 was evaluated in overall healthcare workers (HCWs). In addition, neutralizing antibodies to SARS-CoV-2 were measured according to the subjects’ measles immunity status with serum samples collected before the coronavirus disease 2019 pandemic period. The effectiveness of the MMR vaccine for SARS-CoV-2 in all HCWs and measles IgG-positive subjects was 34% (adjusted odds ratio [aOR] = 1.20, 95% confidence interval [CI] = 0.53–2.70) and 34% (aOR = 0.66, CI = 0.38–18.4), respectively. The neutralizing antibody levels for SARS-CoV-2 were low in all groups regardless of the measles immune status. The MMR vaccine alone may not provide sufficient protection against SARS-CoV-2.https://www.mdpi.com/1999-4915/17/2/215SARS-CoV-2COVID-19measles–mumps–rubella vaccinevaccine effectivenessvaccine immunogenicity |
| spellingShingle | Hyeri Seok Joon-Yong Bae Jooyun Kim Won Suk Choi Heedo Park Jungmin Lee Sohyun Lee Chulwoo Kim Man-Seong Park Dae Won Park Effectiveness and Immunogenicity of the MMR Vaccine Against SARS-CoV-2 Among Healthcare Workers Viruses SARS-CoV-2 COVID-19 measles–mumps–rubella vaccine vaccine effectiveness vaccine immunogenicity |
| title | Effectiveness and Immunogenicity of the MMR Vaccine Against SARS-CoV-2 Among Healthcare Workers |
| title_full | Effectiveness and Immunogenicity of the MMR Vaccine Against SARS-CoV-2 Among Healthcare Workers |
| title_fullStr | Effectiveness and Immunogenicity of the MMR Vaccine Against SARS-CoV-2 Among Healthcare Workers |
| title_full_unstemmed | Effectiveness and Immunogenicity of the MMR Vaccine Against SARS-CoV-2 Among Healthcare Workers |
| title_short | Effectiveness and Immunogenicity of the MMR Vaccine Against SARS-CoV-2 Among Healthcare Workers |
| title_sort | effectiveness and immunogenicity of the mmr vaccine against sars cov 2 among healthcare workers |
| topic | SARS-CoV-2 COVID-19 measles–mumps–rubella vaccine vaccine effectiveness vaccine immunogenicity |
| url | https://www.mdpi.com/1999-4915/17/2/215 |
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