Role of Huangqin Qingre Chubi Capsule in the Reduction of the Risk of Re-Admission in Patients With Ankylosing Spondylitis: A Cohort Study

Yajun Qi,1– 3 Jian Liu,1,3 Yiming Chen,1,3 Yuedi Hu,1,3 Qiao Zhou,1,3 Dan Huang,1,3 Chengzhi Cong,1,3 Yang Li1,3 1The First College of Clinical Medicine, Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, People’s Republic of China; 2College of Acupuncture and Massage, Anhui Univer...

Full description

Saved in:
Bibliographic Details
Main Authors: Qi Y, Liu J, Chen Y, Hu Y, Zhou Q, Huang D, Cong C, Li Y
Format: Article
Language:English
Published: Dove Medical Press 2025-01-01
Series:International Journal of General Medicine
Subjects:
Online Access:https://www.dovepress.com/role-of-huangqin-qingre-chubi-capsule-in-the-reduction-of-the-risk-of--peer-reviewed-fulltext-article-IJGM
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832592079990030336
author Qi Y
Liu J
Chen Y
Hu Y
Zhou Q
Huang D
Cong C
Li Y
author_facet Qi Y
Liu J
Chen Y
Hu Y
Zhou Q
Huang D
Cong C
Li Y
author_sort Qi Y
collection DOAJ
description Yajun Qi,1– 3 Jian Liu,1,3 Yiming Chen,1,3 Yuedi Hu,1,3 Qiao Zhou,1,3 Dan Huang,1,3 Chengzhi Cong,1,3 Yang Li1,3 1The First College of Clinical Medicine, Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, People’s Republic of China; 2College of Acupuncture and Massage, Anhui University of Chinese Medicine, Hefei, Anhui Province, 230012, People’s Republic of China; 3Department of Rheumatology and Immunology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, People’s Republic of ChinaCorrespondence: Jian Liu, Department of Rheumatology and Immunology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, People’s Republic of China, Email liujianahzy@126.comObjective: This study evaluates whether Huangqin Qingre Chubi Capsule (HQC), a traditional Chinese medicine (TCM) compound, is associated with the risk of re-admission in patients with ankylosing spondylitis (AS).Methods: In this study, we retrospectively collected the clinical data of 1,296 AS patients. Patients were allocated into HQC and non-HQC groups. Baseline data between the two groups were matched with propensity score matching (PSM). Influencing factors for the risk of re-admission in AS patients were analyzed with the Cox proportional hazards model. The effect of HQC intervention duration on the risk of re-admission was assessed with Kaplan-Meier survival curves. The random walk model and association rule analysis were utilized to determine the correlation between HQC and improvements in immunoinflammatory markers.Results: The re-admission rate was significantly lower in the HQC group than in the non-HQC group (P < 0.01). The risk of re-admission was significantly lower in patients aged > 40 years (P < 0.01) than in patients aged < 40 years and also markedly lower in HQC users than in non-HQC users (P < 0.01), suggesting that age and the use of HQC were key factors influencing the risk of re-admission. Longer HQC intervention duration was associated with better improvements in ESR, CRP, and C4, and HQC was closely correlated with improvements in ESR, CRP, IgA, and C4.Conclusion: HQC treatment can reduce the risk of re-admission in AS patients, which may be associated with improvements in ESR, CRP, IgA, and C4. The risk decreases with prolonged HQC treatment.Keywords: Huangqin Qingre Chubi Capsule, ankylosing spondylitis, re-admission, cohort study, telephone follow-up
format Article
id doaj-art-9d9bdbc3f91342b0b6c37a16f1aa0e01
institution Kabale University
issn 1178-7074
language English
publishDate 2025-01-01
publisher Dove Medical Press
record_format Article
series International Journal of General Medicine
spelling doaj-art-9d9bdbc3f91342b0b6c37a16f1aa0e012025-01-21T16:58:06ZengDove Medical PressInternational Journal of General Medicine1178-70742025-01-01Volume 1830931999448Role of Huangqin Qingre Chubi Capsule in the Reduction of the Risk of Re-Admission in Patients With Ankylosing Spondylitis: A Cohort StudyQi YLiu JChen YHu YZhou QHuang DCong CLi YYajun Qi,1– 3 Jian Liu,1,3 Yiming Chen,1,3 Yuedi Hu,1,3 Qiao Zhou,1,3 Dan Huang,1,3 Chengzhi Cong,1,3 Yang Li1,3 1The First College of Clinical Medicine, Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, People’s Republic of China; 2College of Acupuncture and Massage, Anhui University of Chinese Medicine, Hefei, Anhui Province, 230012, People’s Republic of China; 3Department of Rheumatology and Immunology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, People’s Republic of ChinaCorrespondence: Jian Liu, Department of Rheumatology and Immunology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, People’s Republic of China, Email liujianahzy@126.comObjective: This study evaluates whether Huangqin Qingre Chubi Capsule (HQC), a traditional Chinese medicine (TCM) compound, is associated with the risk of re-admission in patients with ankylosing spondylitis (AS).Methods: In this study, we retrospectively collected the clinical data of 1,296 AS patients. Patients were allocated into HQC and non-HQC groups. Baseline data between the two groups were matched with propensity score matching (PSM). Influencing factors for the risk of re-admission in AS patients were analyzed with the Cox proportional hazards model. The effect of HQC intervention duration on the risk of re-admission was assessed with Kaplan-Meier survival curves. The random walk model and association rule analysis were utilized to determine the correlation between HQC and improvements in immunoinflammatory markers.Results: The re-admission rate was significantly lower in the HQC group than in the non-HQC group (P < 0.01). The risk of re-admission was significantly lower in patients aged > 40 years (P < 0.01) than in patients aged < 40 years and also markedly lower in HQC users than in non-HQC users (P < 0.01), suggesting that age and the use of HQC were key factors influencing the risk of re-admission. Longer HQC intervention duration was associated with better improvements in ESR, CRP, and C4, and HQC was closely correlated with improvements in ESR, CRP, IgA, and C4.Conclusion: HQC treatment can reduce the risk of re-admission in AS patients, which may be associated with improvements in ESR, CRP, IgA, and C4. The risk decreases with prolonged HQC treatment.Keywords: Huangqin Qingre Chubi Capsule, ankylosing spondylitis, re-admission, cohort study, telephone follow-uphttps://www.dovepress.com/role-of-huangqin-qingre-chubi-capsule-in-the-reduction-of-the-risk-of--peer-reviewed-fulltext-article-IJGMhuangqin qingre chubi capsuleankylosing spondylitisre-admissioncohort studytelephone follow-up
spellingShingle Qi Y
Liu J
Chen Y
Hu Y
Zhou Q
Huang D
Cong C
Li Y
Role of Huangqin Qingre Chubi Capsule in the Reduction of the Risk of Re-Admission in Patients With Ankylosing Spondylitis: A Cohort Study
International Journal of General Medicine
huangqin qingre chubi capsule
ankylosing spondylitis
re-admission
cohort study
telephone follow-up
title Role of Huangqin Qingre Chubi Capsule in the Reduction of the Risk of Re-Admission in Patients With Ankylosing Spondylitis: A Cohort Study
title_full Role of Huangqin Qingre Chubi Capsule in the Reduction of the Risk of Re-Admission in Patients With Ankylosing Spondylitis: A Cohort Study
title_fullStr Role of Huangqin Qingre Chubi Capsule in the Reduction of the Risk of Re-Admission in Patients With Ankylosing Spondylitis: A Cohort Study
title_full_unstemmed Role of Huangqin Qingre Chubi Capsule in the Reduction of the Risk of Re-Admission in Patients With Ankylosing Spondylitis: A Cohort Study
title_short Role of Huangqin Qingre Chubi Capsule in the Reduction of the Risk of Re-Admission in Patients With Ankylosing Spondylitis: A Cohort Study
title_sort role of huangqin qingre chubi capsule in the reduction of the risk of re admission in patients with ankylosing spondylitis a cohort study
topic huangqin qingre chubi capsule
ankylosing spondylitis
re-admission
cohort study
telephone follow-up
url https://www.dovepress.com/role-of-huangqin-qingre-chubi-capsule-in-the-reduction-of-the-risk-of--peer-reviewed-fulltext-article-IJGM
work_keys_str_mv AT qiy roleofhuangqinqingrechubicapsuleinthereductionoftheriskofreadmissioninpatientswithankylosingspondylitisacohortstudy
AT liuj roleofhuangqinqingrechubicapsuleinthereductionoftheriskofreadmissioninpatientswithankylosingspondylitisacohortstudy
AT cheny roleofhuangqinqingrechubicapsuleinthereductionoftheriskofreadmissioninpatientswithankylosingspondylitisacohortstudy
AT huy roleofhuangqinqingrechubicapsuleinthereductionoftheriskofreadmissioninpatientswithankylosingspondylitisacohortstudy
AT zhouq roleofhuangqinqingrechubicapsuleinthereductionoftheriskofreadmissioninpatientswithankylosingspondylitisacohortstudy
AT huangd roleofhuangqinqingrechubicapsuleinthereductionoftheriskofreadmissioninpatientswithankylosingspondylitisacohortstudy
AT congc roleofhuangqinqingrechubicapsuleinthereductionoftheriskofreadmissioninpatientswithankylosingspondylitisacohortstudy
AT liy roleofhuangqinqingrechubicapsuleinthereductionoftheriskofreadmissioninpatientswithankylosingspondylitisacohortstudy