Temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized 13C MRSI thermometry

Temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized 13C MRSI thermometry

Abstract The chemical shift of many molecules changes with temperature, which enables non-invasive magnetic resonance imaging (MRI) thermometry. Hyperpolarization methods increase the inherently low 13C MR signal. The commonly-used hyperpolarized probe [1-13C]pyruvate, and its metabolic product [1-1...

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Main Authors: Wolfgang Gottwald, Luca Nagel, Jason G. Skinner, Martin Grashei, Sandra Sühnel, Nadine Setzer, Wolfgang Eisenreich, Mary A. McLean, Ferdia A. Gallagher, Jae Mo Park, Zumrud Ahmadova, Martin Gierse, Senay Karaali, Stephan Knecht, Ilai Schwartz, Irina Heid, Geoffrey J. Topping, Frits H. A. van Heijster, Franz Schilling
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Imaging
Online Access:https://doi.org/10.1038/s44303-025-00081-3
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