Temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized 13C MRSI thermometry
Abstract The chemical shift of many molecules changes with temperature, which enables non-invasive magnetic resonance imaging (MRI) thermometry. Hyperpolarization methods increase the inherently low 13C MR signal. The commonly-used hyperpolarized probe [1-13C]pyruvate, and its metabolic product [1-1...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
|
| Series: | npj Imaging |
| Online Access: | https://doi.org/10.1038/s44303-025-00081-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849312969325805568 |
|---|---|
| author | Wolfgang Gottwald Luca Nagel Jason G. Skinner Martin Grashei Sandra Sühnel Nadine Setzer Wolfgang Eisenreich Mary A. McLean Ferdia A. Gallagher Jae Mo Park Zumrud Ahmadova Martin Gierse Senay Karaali Stephan Knecht Ilai Schwartz Irina Heid Geoffrey J. Topping Frits H. A. van Heijster Franz Schilling |
| author_facet | Wolfgang Gottwald Luca Nagel Jason G. Skinner Martin Grashei Sandra Sühnel Nadine Setzer Wolfgang Eisenreich Mary A. McLean Ferdia A. Gallagher Jae Mo Park Zumrud Ahmadova Martin Gierse Senay Karaali Stephan Knecht Ilai Schwartz Irina Heid Geoffrey J. Topping Frits H. A. van Heijster Franz Schilling |
| author_sort | Wolfgang Gottwald |
| collection | DOAJ |
| description | Abstract The chemical shift of many molecules changes with temperature, which enables non-invasive magnetic resonance imaging (MRI) thermometry. Hyperpolarization methods increase the inherently low 13C MR signal. The commonly-used hyperpolarized probe [1-13C]pyruvate, and its metabolic product [1-13C]lactate, exhibit temperature and concentration dependent chemical shift changes that have not previously been reported. These effects were characterized at 7 T and 11.7 T in vitro and applied for in vivo thermometry both preclinically at 7 T and to human data at 3 T. Apparent temperature values from mouse abdomen and brain were similar to rectally measured temperature. Human brain and kidney apparent temperatures from 13C MRSI were lower than known physiological temperatures, suggesting that additional effects may currently limit the use of this method for determining absolute temperature in humans. The temperature dependent chemical shift changes also have implications for sequence design and for in vitro studies with hyperpolarized pyruvate. |
| format | Article |
| id | doaj-art-9d99f05871cc4cb092891fe983a458ea |
| institution | Kabale University |
| issn | 2948-197X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Imaging |
| spelling | doaj-art-9d99f05871cc4cb092891fe983a458ea2025-08-20T03:52:55ZengNature Portfolionpj Imaging2948-197X2025-05-013111110.1038/s44303-025-00081-3Temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized 13C MRSI thermometryWolfgang Gottwald0Luca Nagel1Jason G. Skinner2Martin Grashei3Sandra Sühnel4Nadine Setzer5Wolfgang Eisenreich6Mary A. McLean7Ferdia A. Gallagher8Jae Mo Park9Zumrud Ahmadova10Martin Gierse11Senay Karaali12Stephan Knecht13Ilai Schwartz14Irina Heid15Geoffrey J. Topping16Frits H. A. van Heijster17Franz Schilling18Department of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Technical University of MunichDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Technical University of MunichDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Technical University of MunichDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Technical University of MunichDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Technical University of MunichDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Technical University of MunichBavarian NMR Center (BNMRZ), Structural Membrane Biochemistry, TUM School of Natural Sciences, Technical University of MunichCancer Research UK Cambridge Centre, University of CambridgeCancer Research UK Cambridge Centre, University of CambridgeAdvanced Imaging Research Center, University of Texas Southwestern Medical CenterNVision Imaging Technologies GmbHNVision Imaging Technologies GmbHNVision Imaging Technologies GmbHNVision Imaging Technologies GmbHNVision Imaging Technologies GmbHInstitute of Diagnostic and Interventional Radiology, TUM School of Medicine and Health, TUM University Hospital, Technical University of MunichDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Technical University of MunichDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Technical University of MunichDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Technical University of MunichAbstract The chemical shift of many molecules changes with temperature, which enables non-invasive magnetic resonance imaging (MRI) thermometry. Hyperpolarization methods increase the inherently low 13C MR signal. The commonly-used hyperpolarized probe [1-13C]pyruvate, and its metabolic product [1-13C]lactate, exhibit temperature and concentration dependent chemical shift changes that have not previously been reported. These effects were characterized at 7 T and 11.7 T in vitro and applied for in vivo thermometry both preclinically at 7 T and to human data at 3 T. Apparent temperature values from mouse abdomen and brain were similar to rectally measured temperature. Human brain and kidney apparent temperatures from 13C MRSI were lower than known physiological temperatures, suggesting that additional effects may currently limit the use of this method for determining absolute temperature in humans. The temperature dependent chemical shift changes also have implications for sequence design and for in vitro studies with hyperpolarized pyruvate.https://doi.org/10.1038/s44303-025-00081-3 |
| spellingShingle | Wolfgang Gottwald Luca Nagel Jason G. Skinner Martin Grashei Sandra Sühnel Nadine Setzer Wolfgang Eisenreich Mary A. McLean Ferdia A. Gallagher Jae Mo Park Zumrud Ahmadova Martin Gierse Senay Karaali Stephan Knecht Ilai Schwartz Irina Heid Geoffrey J. Topping Frits H. A. van Heijster Franz Schilling Temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized 13C MRSI thermometry npj Imaging |
| title | Temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized 13C MRSI thermometry |
| title_full | Temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized 13C MRSI thermometry |
| title_fullStr | Temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized 13C MRSI thermometry |
| title_full_unstemmed | Temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized 13C MRSI thermometry |
| title_short | Temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized 13C MRSI thermometry |
| title_sort | temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized 13c mrsi thermometry |
| url | https://doi.org/10.1038/s44303-025-00081-3 |
| work_keys_str_mv | AT wolfganggottwald temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT lucanagel temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT jasongskinner temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT martingrashei temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT sandrasuhnel temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT nadinesetzer temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT wolfgangeisenreich temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT maryamclean temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT ferdiaagallagher temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT jaemopark temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT zumrudahmadova temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT martingierse temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT senaykaraali temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT stephanknecht temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT ilaischwartz temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT irinaheid temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT geoffreyjtopping temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT fritshavanheijster temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry AT franzschilling temperaturedependentchemicalshiftsofpyruvateandlactateenableinvivohyperpolarized13cmrsithermometry |