Recent insights into the cellular mechanisms of acute pancreatitis
In acute pancreatitis, initiating cellular events causing acinar cell injury includes co-localization of zymogens with lysosomal hydrolases, leading to premature enzyme activation and pathological exocytosis of zymogens into the interstitial space. This is followed by processes that accentuate cell...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2007/930424 |
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| _version_ | 1832550297109528576 |
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| author | Laura I Cosen-Binker Herbert Y Gaisano |
| author_facet | Laura I Cosen-Binker Herbert Y Gaisano |
| author_sort | Laura I Cosen-Binker |
| collection | DOAJ |
| description | In acute pancreatitis, initiating cellular events causing acinar cell injury includes co-localization of zymogens with lysosomal hydrolases, leading to premature enzyme activation and pathological exocytosis of zymogens into the interstitial space. This is followed by processes that accentuate cell injury; triggering acute inflammatory mediators, intensifying oxidative stress, compromising the microcirculation and activating a neurogenic feedback. Such localized events then progress to a systemic inflammatory response leading to multiorgan dysfunction syndrome with resulting high morbidity and mortality. The present review discusses some of the most recent insights into each of these cellular processes postulated to cause or propagate the process of acute pancreatitis, and also the role of alcohol and genetics. |
| format | Article |
| id | doaj-art-9d8014bb4f204ae7b58841b155a76527 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-9d8014bb4f204ae7b58841b155a765272025-02-03T06:07:10ZengWileyCanadian Journal of Gastroenterology0835-79002007-01-01211192410.1155/2007/930424Recent insights into the cellular mechanisms of acute pancreatitisLaura I Cosen-Binker0Herbert Y Gaisano1Department of Medicine, University Health Network and University of Toronto, Toronto, Ontario, CanadaDepartment of Medicine, University Health Network and University of Toronto, Toronto, Ontario, CanadaIn acute pancreatitis, initiating cellular events causing acinar cell injury includes co-localization of zymogens with lysosomal hydrolases, leading to premature enzyme activation and pathological exocytosis of zymogens into the interstitial space. This is followed by processes that accentuate cell injury; triggering acute inflammatory mediators, intensifying oxidative stress, compromising the microcirculation and activating a neurogenic feedback. Such localized events then progress to a systemic inflammatory response leading to multiorgan dysfunction syndrome with resulting high morbidity and mortality. The present review discusses some of the most recent insights into each of these cellular processes postulated to cause or propagate the process of acute pancreatitis, and also the role of alcohol and genetics.http://dx.doi.org/10.1155/2007/930424 |
| spellingShingle | Laura I Cosen-Binker Herbert Y Gaisano Recent insights into the cellular mechanisms of acute pancreatitis Canadian Journal of Gastroenterology |
| title | Recent insights into the cellular mechanisms of acute pancreatitis |
| title_full | Recent insights into the cellular mechanisms of acute pancreatitis |
| title_fullStr | Recent insights into the cellular mechanisms of acute pancreatitis |
| title_full_unstemmed | Recent insights into the cellular mechanisms of acute pancreatitis |
| title_short | Recent insights into the cellular mechanisms of acute pancreatitis |
| title_sort | recent insights into the cellular mechanisms of acute pancreatitis |
| url | http://dx.doi.org/10.1155/2007/930424 |
| work_keys_str_mv | AT lauraicosenbinker recentinsightsintothecellularmechanismsofacutepancreatitis AT herbertygaisano recentinsightsintothecellularmechanismsofacutepancreatitis |