Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis.
<h4>Background</h4>Chikungunya virus (CHIKV) is an emerging arboviral infection with a global distribution and may cause fetal and neonatal infections after maternal CHIKV-infections during gestation.<h4>Methodology</h4>We performed a systematic review to evaluate the risk fo...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-06-01
|
| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0006510 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850163854356512768 |
|---|---|
| author | Despina Contopoulos-Ioannidis Shoshana Newman-Lindsay Camille Chow A Desiree LaBeaud |
| author_facet | Despina Contopoulos-Ioannidis Shoshana Newman-Lindsay Camille Chow A Desiree LaBeaud |
| author_sort | Despina Contopoulos-Ioannidis |
| collection | DOAJ |
| description | <h4>Background</h4>Chikungunya virus (CHIKV) is an emerging arboviral infection with a global distribution and may cause fetal and neonatal infections after maternal CHIKV-infections during gestation.<h4>Methodology</h4>We performed a systematic review to evaluate the risk for: a) mother-to-child transmission (MTCT), b) antepartum fetal deaths (APFD), c) symptomatic neonatal disease, and d) neonatal deaths from maternal CHIKV-infections during gestation. We also recorded the neonatal clinical manifestations after such maternal infections (qualitative data synthesis). We searched PubMed (last search 3/2017) for articles, of any study design, with any of the above outcomes. We calculated the overall risk of MTCT, APFDs and risk of symptomatic neonatal disease by simple pooling. For endpoints with ≥5 events in more than one study, we also synthesized the data by random-effect-model (REM) meta-analysis.<h4>Principal findings</h4>Among 563 identified articles, 13 articles from 8 cohorts were included in the quantitative data synthesis and 33 articles in the qualitative data synthesis. Most cohorts reported data only on symptomatic rather than on all neonatal infections. By extrapolation also of these data, the overall pooled-MTCT-risk across cohorts was at least 15.5% (206/1331), (12.6% by REMs). The pooled APFD-risk was 1.7% (20/1203); while the risk of CHIKV-confirmed-APFDs was 0.3% (3/1203). Overall, the pooled-risk of symptomatic neonatal disease was 15.3% (203/1331), (11.9% by REMs). The pooled risk of symptomatic disease was 50.0% (23/46) among intrapartum vs 0% (0/712) among antepartum/peripartum maternal infections. Infected newborns, from maternal infections during gestation were either asymptomatic or presented within their first week of life, but not at birth, with fever, irritability, hyperalgesia, diffuse limb edema, rashes and occasionally sepsis-like illness and meningoencephalitis. The pooled-risk of neonatal death was 0.6% (5/832) among maternal infections and 2.8% (5/182) among neonatal infections; long-term neurodevelopmental delays occurred in 50% of symptomatic neonatal infections.<h4>Conclusions/significance</h4>Published cohorts with data on the risk to the fetus and/or newborn from maternal CHIKV-infections during gestation were sparse compared to the number of recently reported CHIKV-infection outbreaks worldwide; however perinatal infections do occur, at high rates during intrapartum period, and can be related to neonatal death and long-term disabilities. |
| format | Article |
| id | doaj-art-9d7f6bb9f979470fb30637e89c3e5c8b |
| institution | OA Journals |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-9d7f6bb9f979470fb30637e89c3e5c8b2025-08-20T02:22:06ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352018-06-01126e000651010.1371/journal.pntd.0006510Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis.Despina Contopoulos-IoannidisShoshana Newman-LindsayCamille ChowA Desiree LaBeaud<h4>Background</h4>Chikungunya virus (CHIKV) is an emerging arboviral infection with a global distribution and may cause fetal and neonatal infections after maternal CHIKV-infections during gestation.<h4>Methodology</h4>We performed a systematic review to evaluate the risk for: a) mother-to-child transmission (MTCT), b) antepartum fetal deaths (APFD), c) symptomatic neonatal disease, and d) neonatal deaths from maternal CHIKV-infections during gestation. We also recorded the neonatal clinical manifestations after such maternal infections (qualitative data synthesis). We searched PubMed (last search 3/2017) for articles, of any study design, with any of the above outcomes. We calculated the overall risk of MTCT, APFDs and risk of symptomatic neonatal disease by simple pooling. For endpoints with ≥5 events in more than one study, we also synthesized the data by random-effect-model (REM) meta-analysis.<h4>Principal findings</h4>Among 563 identified articles, 13 articles from 8 cohorts were included in the quantitative data synthesis and 33 articles in the qualitative data synthesis. Most cohorts reported data only on symptomatic rather than on all neonatal infections. By extrapolation also of these data, the overall pooled-MTCT-risk across cohorts was at least 15.5% (206/1331), (12.6% by REMs). The pooled APFD-risk was 1.7% (20/1203); while the risk of CHIKV-confirmed-APFDs was 0.3% (3/1203). Overall, the pooled-risk of symptomatic neonatal disease was 15.3% (203/1331), (11.9% by REMs). The pooled risk of symptomatic disease was 50.0% (23/46) among intrapartum vs 0% (0/712) among antepartum/peripartum maternal infections. Infected newborns, from maternal infections during gestation were either asymptomatic or presented within their first week of life, but not at birth, with fever, irritability, hyperalgesia, diffuse limb edema, rashes and occasionally sepsis-like illness and meningoencephalitis. The pooled-risk of neonatal death was 0.6% (5/832) among maternal infections and 2.8% (5/182) among neonatal infections; long-term neurodevelopmental delays occurred in 50% of symptomatic neonatal infections.<h4>Conclusions/significance</h4>Published cohorts with data on the risk to the fetus and/or newborn from maternal CHIKV-infections during gestation were sparse compared to the number of recently reported CHIKV-infection outbreaks worldwide; however perinatal infections do occur, at high rates during intrapartum period, and can be related to neonatal death and long-term disabilities.https://doi.org/10.1371/journal.pntd.0006510 |
| spellingShingle | Despina Contopoulos-Ioannidis Shoshana Newman-Lindsay Camille Chow A Desiree LaBeaud Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis. PLoS Neglected Tropical Diseases |
| title | Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis. |
| title_full | Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis. |
| title_fullStr | Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis. |
| title_full_unstemmed | Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis. |
| title_short | Mother-to-child transmission of Chikungunya virus: A systematic review and meta-analysis. |
| title_sort | mother to child transmission of chikungunya virus a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pntd.0006510 |
| work_keys_str_mv | AT despinacontopoulosioannidis mothertochildtransmissionofchikungunyavirusasystematicreviewandmetaanalysis AT shoshananewmanlindsay mothertochildtransmissionofchikungunyavirusasystematicreviewandmetaanalysis AT camillechow mothertochildtransmissionofchikungunyavirusasystematicreviewandmetaanalysis AT adesireelabeaud mothertochildtransmissionofchikungunyavirusasystematicreviewandmetaanalysis |