Molecular diagnostics of cardiac allograft rejection: development pathways and future clinical prospects
Recent advances in molecular diagnostics have opened new avenues for integrating genetic and epigenetic bio- markers into clinical practice. Areas such as gene expression profiling, extracellular DNA quantification, and microRNA expression analysis have seen significant development in recent years....
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2025-07-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/1954 |
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| author | D D. Velikiy S. O. Sharapchenko A. O. Shevchenko O. P. Shevchenko |
| author_facet | D D. Velikiy S. O. Sharapchenko A. O. Shevchenko O. P. Shevchenko |
| author_sort | D D. Velikiy |
| collection | DOAJ |
| description | Recent advances in molecular diagnostics have opened new avenues for integrating genetic and epigenetic bio- markers into clinical practice. Areas such as gene expression profiling, extracellular DNA quantification, and microRNA expression analysis have seen significant development in recent years. The diagnostic value of mo- lecular genetic biomarkers has been demonstrated across a range of pathological conditions. Emerging clinical data now support the use of molecular diagnostics to detect post-transplant complications in recipients of solid organ transplants. In heart transplant recipients, a comprehensive assessment that includes molecular genetics, epigenetic, and clinical parameters is essential for personalized selection of immunosuppressive therapy and for prevention of graft dysfunction and vasculopathy. This review highlights the current state of molecular diagnostics in cardiac allograft rejection and explores its potential for clinical application. |
| format | Article |
| id | doaj-art-9d75bf0b29754e5faf12ebf7a8d10a2f |
| institution | DOAJ |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2025-07-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-9d75bf0b29754e5faf12ebf7a8d10a2f2025-08-20T03:01:39ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912025-07-0127217117810.15825/1995-1191-2025-2-171-1781351Molecular diagnostics of cardiac allograft rejection: development pathways and future clinical prospectsD D. Velikiy0S. O. Sharapchenko1A. O. Shevchenko2O. P. Shevchenko3Shumakov National Medical Research Center of Transplantology and Artificial OrgansShumakov National Medical Research Center of Transplantology and Artificial OrgansShumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov University, Moscow, Russian Federation Pirogov Russian National Research Medical UniversityShumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov University, Moscow, Russian FederationRecent advances in molecular diagnostics have opened new avenues for integrating genetic and epigenetic bio- markers into clinical practice. Areas such as gene expression profiling, extracellular DNA quantification, and microRNA expression analysis have seen significant development in recent years. The diagnostic value of mo- lecular genetic biomarkers has been demonstrated across a range of pathological conditions. Emerging clinical data now support the use of molecular diagnostics to detect post-transplant complications in recipients of solid organ transplants. In heart transplant recipients, a comprehensive assessment that includes molecular genetics, epigenetic, and clinical parameters is essential for personalized selection of immunosuppressive therapy and for prevention of graft dysfunction and vasculopathy. This review highlights the current state of molecular diagnostics in cardiac allograft rejection and explores its potential for clinical application.https://journal.transpl.ru/vtio/article/view/1954heart transplantationgene expression profilingextracellular dnamirnagraft rejectionpersonalization |
| spellingShingle | D D. Velikiy S. O. Sharapchenko A. O. Shevchenko O. P. Shevchenko Molecular diagnostics of cardiac allograft rejection: development pathways and future clinical prospects Вестник трансплантологии и искусственных органов heart transplantation gene expression profiling extracellular dna mirna graft rejection personalization |
| title | Molecular diagnostics of cardiac allograft rejection: development pathways and future clinical prospects |
| title_full | Molecular diagnostics of cardiac allograft rejection: development pathways and future clinical prospects |
| title_fullStr | Molecular diagnostics of cardiac allograft rejection: development pathways and future clinical prospects |
| title_full_unstemmed | Molecular diagnostics of cardiac allograft rejection: development pathways and future clinical prospects |
| title_short | Molecular diagnostics of cardiac allograft rejection: development pathways and future clinical prospects |
| title_sort | molecular diagnostics of cardiac allograft rejection development pathways and future clinical prospects |
| topic | heart transplantation gene expression profiling extracellular dna mirna graft rejection personalization |
| url | https://journal.transpl.ru/vtio/article/view/1954 |
| work_keys_str_mv | AT ddvelikiy moleculardiagnosticsofcardiacallograftrejectiondevelopmentpathwaysandfutureclinicalprospects AT sosharapchenko moleculardiagnosticsofcardiacallograftrejectiondevelopmentpathwaysandfutureclinicalprospects AT aoshevchenko moleculardiagnosticsofcardiacallograftrejectiondevelopmentpathwaysandfutureclinicalprospects AT opshevchenko moleculardiagnosticsofcardiacallograftrejectiondevelopmentpathwaysandfutureclinicalprospects |