Are adenoviruses zoonotic? A systematic review of the evidence
Adenoviruses (AdVs) are major contributors to clinical illnesses. Novel human and animal AdVs continue to be identified and characterized. Comparative analyses using bioinformatic methods and Omics-based technologies allow insights into how these human pathogens have emerged and their potential for...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2019.1690953 |
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| author | Laura K. Borkenhagen Jane K. Fieldhouse Donald Seto Gregory C. Gray |
| author_facet | Laura K. Borkenhagen Jane K. Fieldhouse Donald Seto Gregory C. Gray |
| author_sort | Laura K. Borkenhagen |
| collection | DOAJ |
| description | Adenoviruses (AdVs) are major contributors to clinical illnesses. Novel human and animal AdVs continue to be identified and characterized. Comparative analyses using bioinformatic methods and Omics-based technologies allow insights into how these human pathogens have emerged and their potential for host cross-species transmission. Systematic review of literature published across ProQuest, Pubmed, and Web of Science databases for evidence of adenoviral zoonotic potential identified 589 citations. After removing duplicates, 327 citations were screened for relevance; of which, 74 articles received full-text reviews. Among these, 24 were included here, of which 16 demonstrated evidence of zoonotic transmission of AdVs. These documented instances of AdV crossing host species barriers between humans and non-human primate, bat, feline, swine, canine, ovine, and caprine. Eight studies sought to but did not find evidence of zoonosis. The findings demonstrate substantial evidence suggesting AdVs have previously and will continue crossing host species barriers. These have human health consequences both in terms of novel pathogen emergence and epidemic outbreaks, and of appropriate and safe use of non-human adenoviruses for therapeutics. As routine human clinical diagnostics may miss a novel cross-species adenovirus infection in humans, next generation sequencing or panspecies molecular diagnostics may be necessary to detect such incursions. |
| format | Article |
| id | doaj-art-9d70e824487a4e089ecf95b29c55fccc |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-9d70e824487a4e089ecf95b29c55fccc2025-08-20T02:26:10ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512019-01-01811679168710.1080/22221751.2019.1690953Are adenoviruses zoonotic? A systematic review of the evidenceLaura K. Borkenhagen0Jane K. Fieldhouse1Donald Seto2Gregory C. Gray3Division of Infectious Diseases, School of Medicine and Global Health Institute, Duke University, Durham, NC, USADivision of Infectious Diseases, School of Medicine and Global Health Institute, Duke University, Durham, NC, USABioinformatics and Computational Biology Program, School of Systems Biology, George Mason University, Manassas, VA, USADivision of Infectious Diseases, School of Medicine and Global Health Institute, Duke University, Durham, NC, USAAdenoviruses (AdVs) are major contributors to clinical illnesses. Novel human and animal AdVs continue to be identified and characterized. Comparative analyses using bioinformatic methods and Omics-based technologies allow insights into how these human pathogens have emerged and their potential for host cross-species transmission. Systematic review of literature published across ProQuest, Pubmed, and Web of Science databases for evidence of adenoviral zoonotic potential identified 589 citations. After removing duplicates, 327 citations were screened for relevance; of which, 74 articles received full-text reviews. Among these, 24 were included here, of which 16 demonstrated evidence of zoonotic transmission of AdVs. These documented instances of AdV crossing host species barriers between humans and non-human primate, bat, feline, swine, canine, ovine, and caprine. Eight studies sought to but did not find evidence of zoonosis. The findings demonstrate substantial evidence suggesting AdVs have previously and will continue crossing host species barriers. These have human health consequences both in terms of novel pathogen emergence and epidemic outbreaks, and of appropriate and safe use of non-human adenoviruses for therapeutics. As routine human clinical diagnostics may miss a novel cross-species adenovirus infection in humans, next generation sequencing or panspecies molecular diagnostics may be necessary to detect such incursions.https://www.tandfonline.com/doi/10.1080/22221751.2019.1690953Adenoviruszoonoticanthropozoonosiszooanthroponosiscross-species |
| spellingShingle | Laura K. Borkenhagen Jane K. Fieldhouse Donald Seto Gregory C. Gray Are adenoviruses zoonotic? A systematic review of the evidence Emerging Microbes and Infections Adenovirus zoonotic anthropozoonosis zooanthroponosis cross-species |
| title | Are adenoviruses zoonotic? A systematic review of the evidence |
| title_full | Are adenoviruses zoonotic? A systematic review of the evidence |
| title_fullStr | Are adenoviruses zoonotic? A systematic review of the evidence |
| title_full_unstemmed | Are adenoviruses zoonotic? A systematic review of the evidence |
| title_short | Are adenoviruses zoonotic? A systematic review of the evidence |
| title_sort | are adenoviruses zoonotic a systematic review of the evidence |
| topic | Adenovirus zoonotic anthropozoonosis zooanthroponosis cross-species |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2019.1690953 |
| work_keys_str_mv | AT laurakborkenhagen areadenoviruseszoonoticasystematicreviewoftheevidence AT janekfieldhouse areadenoviruseszoonoticasystematicreviewoftheevidence AT donaldseto areadenoviruseszoonoticasystematicreviewoftheevidence AT gregorycgray areadenoviruseszoonoticasystematicreviewoftheevidence |