Anti-inflammatory and Anti-arthritic Activities of Merremia tridentate (L.) Hall. f.
The various extracts of Merremia tridentate were investigated for its anti-inflammatory and anti-arthritic activities in male albino rats. The anti-inflammatory activity was carried out using carrageenan-induced rat paw oedema model and the anti-arthritic activity was carried out using complete Freu...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2009/670617 |
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| author | M. Kamalutheen S. Gopalakrishnan T. Syed Ismail |
| author_facet | M. Kamalutheen S. Gopalakrishnan T. Syed Ismail |
| author_sort | M. Kamalutheen |
| collection | DOAJ |
| description | The various extracts of Merremia tridentate were investigated for its anti-inflammatory and anti-arthritic activities in male albino rats. The anti-inflammatory activity was carried out using carrageenan-induced rat paw oedema model and the anti-arthritic activity was carried out using complete Freund’s adjuvant induced arthritis model. Indomethacin (10 mg/kg bw) was used as a standard drug. The ethanol extract of M. tridentate exhibited significant dose dependent activity in acute inflammation and the doses of 100 mg/kg bw and 200 mg/kg bw produced 38.3% and 42.8% inhibition respectively after 3 h as compared with that of the standard drug which showed 48.5% inhibition. In arthritis model, the doses of 100 mg/kg bw and 200 mg/kg bw of the ethanol extract produced 49.0% and 51.7% inhibition respectively after 19 days when compared with that of the standard drug (55.5%). Both doses of the ethanol extract of M. tridentate exhibit significant anti-inflammatory and anti-arthritic activities. |
| format | Article |
| id | doaj-art-9d6a032f5ecd47efbfad037ff2f913c6 |
| institution | OA Journals |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
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| series | E-Journal of Chemistry |
| spelling | doaj-art-9d6a032f5ecd47efbfad037ff2f913c62025-08-20T02:20:18ZengWileyE-Journal of Chemistry0973-49452090-98102009-01-016494394810.1155/2009/670617Anti-inflammatory and Anti-arthritic Activities of Merremia tridentate (L.) Hall. f.M. Kamalutheen0S. Gopalakrishnan1T. Syed Ismail2Department of Chemistry, Sadakathullah Appa College, Palayamkottai, Tirunelveli, Tamilnadu, IndiaDepartment of Chemistry, Manonmaniam Sundaranar University, Tirunelveli-627012, Tamilnadu, IndiaDepartment of Chemistry, Sadakathullah Appa College, Palayamkottai, Tirunelveli, Tamilnadu, IndiaThe various extracts of Merremia tridentate were investigated for its anti-inflammatory and anti-arthritic activities in male albino rats. The anti-inflammatory activity was carried out using carrageenan-induced rat paw oedema model and the anti-arthritic activity was carried out using complete Freund’s adjuvant induced arthritis model. Indomethacin (10 mg/kg bw) was used as a standard drug. The ethanol extract of M. tridentate exhibited significant dose dependent activity in acute inflammation and the doses of 100 mg/kg bw and 200 mg/kg bw produced 38.3% and 42.8% inhibition respectively after 3 h as compared with that of the standard drug which showed 48.5% inhibition. In arthritis model, the doses of 100 mg/kg bw and 200 mg/kg bw of the ethanol extract produced 49.0% and 51.7% inhibition respectively after 19 days when compared with that of the standard drug (55.5%). Both doses of the ethanol extract of M. tridentate exhibit significant anti-inflammatory and anti-arthritic activities.http://dx.doi.org/10.1155/2009/670617 |
| spellingShingle | M. Kamalutheen S. Gopalakrishnan T. Syed Ismail Anti-inflammatory and Anti-arthritic Activities of Merremia tridentate (L.) Hall. f. E-Journal of Chemistry |
| title | Anti-inflammatory and Anti-arthritic Activities of Merremia tridentate (L.) Hall. f. |
| title_full | Anti-inflammatory and Anti-arthritic Activities of Merremia tridentate (L.) Hall. f. |
| title_fullStr | Anti-inflammatory and Anti-arthritic Activities of Merremia tridentate (L.) Hall. f. |
| title_full_unstemmed | Anti-inflammatory and Anti-arthritic Activities of Merremia tridentate (L.) Hall. f. |
| title_short | Anti-inflammatory and Anti-arthritic Activities of Merremia tridentate (L.) Hall. f. |
| title_sort | anti inflammatory and anti arthritic activities of merremia tridentate l hall f |
| url | http://dx.doi.org/10.1155/2009/670617 |
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