Akt3 links mitochondrial function to the regulation of Aurora B and mitotic fidelity.

Akt3 links mitochondrial function to the regulation of Aurora B and mitotic fidelity.

Akt3 is a key regulator of mitochondrial homeostasis in the endothelium. Akt3 depletion results in mitochondrial dysfunction, decreased mitochondrial biogenesis, and decreased angiogenesis. Here we link mitochondrial homeostasis with mitotic fidelity-depletion of Akt3 results in the missegregation o...

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Main Authors: Zachary J Hough, Fatemeh Nasehi, Daniel G Corum, Russell A Norris, Ann C Foley, Robin C Muise-Helmericks
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0315751
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