Immunoconjugates as an Efficient Platform for Drug Delivery: A Resurgence of Natural Products in Targeted Antitumor Therapy

Immunoconjugates as an Efficient Platform for Drug Delivery: A Resurgence of Natural Products in Targeted Antitumor Therapy

The present review provides a detailed and comprehensive discussion on antibody–drug conjugates (ADCs) as an evolving new modality in the current therapeutic landscape of malignant diseases. The principle concepts of targeted delivery of highly toxic agents forsaken as stand-alone drugs are examined...

Full description

Saved in:

Bibliographic Details
Main Authors:	Rositsa Mihaylova, Denitsa Momekova, Viktoria Elincheva, Georgi Momekov
Format:	Article
Language:	English
Published:	MDPI AG 2024-12-01
Series:	Pharmaceuticals
Subjects:	ADC immunotoxins targeted antitumor therapy drug delivery dolastatins calicheamicins
Online Access:	https://www.mdpi.com/1424-8247/17/12/1701
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Effect of a supramolecular delivery system based on hyaluronic acid with cyclodextrin on the antitumor properties of oxaliplatin <i>in vitro</i>
by: E. A. Pashkina, et al.
Published: (2024-09-01)

The antitumor mechanisms of glabridin and drug delivery strategies for enhancing its bioavailability
by: Chong Li, et al.
Published: (2024-12-01)

Efficacy of Anti-Cancer Immune Responses Elicited Using Tumor-Targeted IL-2 Cytokine and Its Derivatives in Combined Preclinical Therapies
by: Sahar Balkhi, et al.
Published: (2025-01-01)

Palbociclib as an Antitumor Drug: A License to Kill
by: Agnieszka Łupicka-Słowik, et al.
Published: (2024-11-01)

Engineered probiotic-mediated intratumoral delivery and controlled release of bacterial collagenase for cancer therapy
by: Hong-Rui Li, et al.
Published: (2025-03-01)

Comparative Efficacy of Ribosome-Inactivating Protein-Containing Immunotoxins in 2D and 3D Models of Sarcoma
by: Giulia Calafato, et al.
Published: (2025-06-01)

Antitumor vector systems based on bioactive lectin of <em>Bacillus subtilis </em>ІМВ B-7724
by: A. L. Petranovska, et al.
Published: (2021-08-01)

Antitumor activity of flavonoids
by: Y. F. Zverev
Published: (2019-08-01)

Development and Characterization of Dual-Loaded Niosomal Ion-Sensitive In Situ Gel for Ocular Delivery
by: Viliana Gugleva, et al.
Published: (2024-12-01)

Unlocking the potential of engineered microbes in immunotoxin-based cancer therapy
by: Quan Wang, et al.
Published: (2025-06-01)

Rapid diagnostic imaging and targeted immunotoxin delivery in aggressive prostate cancer using CEACAM5-specific nanobodies
by: Zhaoming Xiao, et al.
Published: (2025-07-01)

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy
by: Huifang Wang, et al.
Published: (2025-05-01)

MODELING OF TARGETED DRUG DELIVERY PART II. MULTIPLE DRUG ADMINISTRATION
by: A. V. Zaborovskiy, et al.
Published: (2017-06-01)

Study of Desorbtion and Exemption of Terpeno-indole Alkaloids of Vinkristin and Vinblastin from Erythrocitary Cell Carriers
by: O. V. Trineeva, et al.
Published: (2019-05-01)

Bio-SS-TS as a Targeted Antitumor Drug Exerts an Anti-Liver Cancer Effect by Enhancing Mitochondria-Dependent Apoptosis
by: Jian Li, et al.
Published: (2025-03-01)

Copper-based metal–organic frameworks for antitumor application
by: Yangwei Qian, et al.
Published: (2025-02-01)

A new treatment for canine B-cell lymphoma based on a recombinant single-domain antibody immunotoxin derived from Pseudomonas aeruginosa exotoxin A
by: Ana S. André, et al.
Published: (2025-04-01)

Multi-shell gold nanoparticles functionalized with methotrexate: a novel nanotherapeutic approach for improved antitumoral and antioxidant activity and enhanced biocompatibility
by: Denisse-Iulia Bostiog, et al.
Published: (2024-12-01)

Biosynthesis of Silver Nanoparticles from Microbacterium sp. for Determination of Antibacterial and Antitumor
by: Thuraya Mehbas Dewan, et al.
Published: (2023-10-01)

Advancing pancreatic cancer therapy by mesothelin-specific nanobody conjugation
by: Soyeon Yi, et al.
Published: (2025-04-01)

Progress of mesenchymal stem cell-derived exosomes in targeted delivery of antitumor drugs
by: Defa Huang, et al.
Published: (2025-04-01)

A conceptual exploration on the synergistic anti-tumor effects of high-order combination of OHSV2-DSTEFAP5/CD3, CAR-T cells, and immunotoxins in hepatocellular carcinoma
by: Shuang Dong, et al.
Published: (2025-05-01)

Antitumor properties of nuclear erythroid cells
by: V. A. Kozlov, et al.
Published: (2022-06-01)

Preclinical development of ozuriftamab vedotin (BA3021), a novel ROR2-specific conditionally active biologic antibody–drug conjugate
by: Hwai Wen Chang, et al.
Published: (2025-12-01)

Pyroptosis‐Inducing Biomaterials Pave the Way for Transformative Antitumor Immunotherapy
by: Hao Yin, et al.
Published: (2024-12-01)

Nanoparticle-mediated delivery of oncolytic viral genomes: an innovative strategy for tumor-targeted immunotherapy
by: Junhan Yang, et al.
Published: (2025-05-01)

Treatment of c-MET Antibody-Drug Conjugate Asymptomatic Pneumonitis with a Novel Steroid Regimen in Non–Small Cell Lung Cancer: A Case Report
by: Daniel A. Fox, et al.
Published: (2025-02-01)

Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors
by: Yaqing Zuo, et al.
Published: (2022-12-01)

Antitumor efficacy of biosynthesized manganese nanoparticles
by: Eman Abuheiba, et al.
Published: (2019-06-01)

The use of xenogenic testicular antigens for induction of antitumor reactions
by: G. V. Seledtsova, et al.
Published: (2024-01-01)

SIMULATION OF TARGETED TRANSPORT FOR DRUG SUBSTANCES PART 1: A SINGLE ADMINISTRATION
by: A. V. Zaborovskiy, et al.
Published: (2017-03-01)

Antibody conjugates in neuroblastoma: a step forward in precision medicine
by: Jihane Balla, et al.
Published: (2025-03-01)

Antitumor activity of synthetic naphthoquinone derivatives (review)
by: E. L. Golovina, et al.
Published: (2025-03-01)

Clinical advances in antibody-drug conjugates for hematological malignancies
by: TANG Sijie, et al.
Published: (2024-12-01)

Magnetically sensitive nanocomposites for targeted antitumor therapy with application of gemcitabine
by: N. M. Korniichuk, et al.
Published: (2020-11-01)

The Antioxidant and Antitumor Effects of Al-gae from the Persian Gulf: A Systematic Re-view
by: Erfan Jamei, et al.
Published: (2025-02-01)

ANTITUMOR ACTIVITY IN VIVO OF AQUEOUS AND ALCOHOLIC EXTRACTS OF THYMUS MARSCHALLIANUS WILLD
by: A. S. Sheremetyeva, et al.
Published: (2021-12-01)

Investigation of chitin grafting: thermal, antioxidant and antitumor properties
by: Nevin Çankaya, et al.
Published: (2025-01-01)

Grapefruit-Derived Vesicles Loaded with Recombinant HSP70 Activate Antitumor Immunity in Colon Cancer In Vitro and In Vivo
by: Luiza Garaeva, et al.
Published: (2024-12-01)

Intracellular trafficking of furin enhances cellular intoxication by recombinant immunotoxins based on Pseudomonas exotoxin A
by: Brian D. Grossman, et al.
Published: (2025-06-01)