A case of accidental vincristine overdose and effective use of therapeutic plasma exchange in its management
Vincristine is a common drug used in hematological malignancy with a maximum per dose limited to 2 mg mainly to limit neurotoxicity. Vincristine overdose and wrong route of administration, though has been reported in world literature, but its appropriate management is still undefined. We report a ca...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2020-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2020;volume=41;issue=5;spage=770;epage=772;aulast=Goyal |
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| author | Hari Goyal Anil Khetarpal Amit Kumar Jain |
| author_facet | Hari Goyal Anil Khetarpal Amit Kumar Jain |
| author_sort | Hari Goyal |
| collection | DOAJ |
| description | Vincristine is a common drug used in hematological malignancy with a maximum per dose limited to 2 mg mainly to limit neurotoxicity. Vincristine overdose and wrong route of administration, though has been reported in world literature, but its appropriate management is still undefined. We report a case of Hodgkin lymphoma being treated with adriamycin, bleomycin, vinblastine and dacarbazine protocol, where vincristine was accidently administrated instead of vinblastine due to its “look-alike, sound-alike” nature. The patient developed severe toxicity due to the same, which was effectively managed by therapeutic plasma exchange. |
| format | Article |
| id | doaj-art-9d63eb8bf7744cdaaa184576b7afce57 |
| institution | DOAJ |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-9d63eb8bf7744cdaaa184576b7afce572025-08-20T03:19:46ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292020-01-0141577077210.4103/ijmpo.ijmpo_116_20A case of accidental vincristine overdose and effective use of therapeutic plasma exchange in its managementHari GoyalAnil KhetarpalAmit Kumar JainVincristine is a common drug used in hematological malignancy with a maximum per dose limited to 2 mg mainly to limit neurotoxicity. Vincristine overdose and wrong route of administration, though has been reported in world literature, but its appropriate management is still undefined. We report a case of Hodgkin lymphoma being treated with adriamycin, bleomycin, vinblastine and dacarbazine protocol, where vincristine was accidently administrated instead of vinblastine due to its “look-alike, sound-alike” nature. The patient developed severe toxicity due to the same, which was effectively managed by therapeutic plasma exchange.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2020;volume=41;issue=5;spage=770;epage=772;aulast=Goyallook-alikesound-alike drugsmedication erroroverdosetherapeutic plasma exchangevincristine |
| spellingShingle | Hari Goyal Anil Khetarpal Amit Kumar Jain A case of accidental vincristine overdose and effective use of therapeutic plasma exchange in its management Indian Journal of Medical and Paediatric Oncology look-alike sound-alike drugs medication error overdose therapeutic plasma exchange vincristine |
| title | A case of accidental vincristine overdose and effective use of therapeutic plasma exchange in its management |
| title_full | A case of accidental vincristine overdose and effective use of therapeutic plasma exchange in its management |
| title_fullStr | A case of accidental vincristine overdose and effective use of therapeutic plasma exchange in its management |
| title_full_unstemmed | A case of accidental vincristine overdose and effective use of therapeutic plasma exchange in its management |
| title_short | A case of accidental vincristine overdose and effective use of therapeutic plasma exchange in its management |
| title_sort | case of accidental vincristine overdose and effective use of therapeutic plasma exchange in its management |
| topic | look-alike sound-alike drugs medication error overdose therapeutic plasma exchange vincristine |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2020;volume=41;issue=5;spage=770;epage=772;aulast=Goyal |
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