Effectiveness of Protein-enriched oral nutritional supplements on muscle function in middle-aged and elderly women: A randomized controlled trial
Objectives: This study evaluated the effects of protein-enriched oral nutritional supplementation (ONS) consumption for 12 weeks on muscle mass, muscular strength, and function in middle-aged and elderly women. Design: A single-center, double-blind, randomized controlled trial Participants: This stu...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-05-01
|
| Series: | The Journal of Nutrition, Health and Aging |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1279770725000314 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849720549684543488 |
|---|---|
| author | Minji Kang Hyunkyung Rho Minhui Kim Miji Lee Yunsook Lim Jinmann Chon Hyunjung Lim |
| author_facet | Minji Kang Hyunkyung Rho Minhui Kim Miji Lee Yunsook Lim Jinmann Chon Hyunjung Lim |
| author_sort | Minji Kang |
| collection | DOAJ |
| description | Objectives: This study evaluated the effects of protein-enriched oral nutritional supplementation (ONS) consumption for 12 weeks on muscle mass, muscular strength, and function in middle-aged and elderly women. Design: A single-center, double-blind, randomized controlled trial Participants: This study was conducted with 70 healthy female participants aged 50–80. Intervention and measurements: Participants were instructed to incorporate two daily packs of either the test ONS (Nucare Active, Daesang Wellife Corp., Seoul, Republic of Korea; 200 kcal/pack, 23 g carbohydrate, 6 g fat, and 15 g protein including branched chain amino acids or placebo ONS (200 kcal/pack, 33 g carbohydrate, 8 g fat, and 1 g protein) into their routine for 12 weeks while maintaining their regular lifestyle. The primary outcome was lean body mass (LBM), while secondary outcomes included muscular strength, physical performance ability, inflammatory markers, and body fat mass (FM). Results: Sixty-four participants (33 in the test group, 31 in the placebo group; mean ± SD age, [test] 63.06 ± 5.51 years, [placebo] 63.29 ± 3.28 years, p = 0.839) completed the 12-week protocol. The test group exhibited a higher percentage change in LBM than the placebo group (0.26 % [95%CI: −0.27, 0.78] vs. −0.47 % [95%CI: −0.81, −0.13]; p = 0.020). The placebo group experienced a significant increase in FM (38.15 % [95%CI: 36.62, 39.69] to 38.67 % [95%CI: 37.14, 40.21]; p < 0.01). The difference in the changes in LBM/BMI and FM/BMI between the two groups was also visually distinct. There were no significant differences between the two groups in terms of muscular strength, physical performance ability, or inflammatory markers. Conclusions: Protein-enriched ONS helped maintain LBM and prevent FM gain in middle-aged and elderly females. This suggests its potential role in preventing frailty and musculoskeletal disorders associated with female aging. |
| format | Article |
| id | doaj-art-9d6178421d1345048cc34eb8a8bba45b |
| institution | DOAJ |
| issn | 1760-4788 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Journal of Nutrition, Health and Aging |
| spelling | doaj-art-9d6178421d1345048cc34eb8a8bba45b2025-08-20T03:11:54ZengElsevierThe Journal of Nutrition, Health and Aging1760-47882025-05-0129510050810.1016/j.jnha.2025.100508Effectiveness of Protein-enriched oral nutritional supplements on muscle function in middle-aged and elderly women: A randomized controlled trialMinji Kang0Hyunkyung Rho1Minhui Kim2Miji Lee3Yunsook Lim4Jinmann Chon5Hyunjung Lim6Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Giheong-gu, Yongin 17104, Republic of Korea; Research Institute of Medical Nutrition, Kyung Hee University, Dongdaemoon-gu, Seoul 02447, Republic of KoreaDepartment of Food and Nutrition, Kyung Hee University, Dongdaemoon-gu, Seoul 02447, Republic of KoreaDepartment of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Giheong-gu, Yongin 17104, Republic of Korea; Research Institute of Medical Nutrition, Kyung Hee University, Dongdaemoon-gu, Seoul 02447, Republic of KoreaDepartment of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Giheong-gu, Yongin 17104, Republic of Korea; Research Institute of Medical Nutrition, Kyung Hee University, Dongdaemoon-gu, Seoul 02447, Republic of KoreaDepartment of Food and Nutrition, Kyung Hee University, Dongdaemoon-gu, Seoul 02447, Republic of KoreaDepartment of Rehabilitation Medicine, Kyung Hee University Medical Center, Dongdaemun-gu, Seoul 02447, Republic of Korea; Corresponding author.Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Giheong-gu, Yongin 17104, Republic of Korea; Research Institute of Medical Nutrition, Kyung Hee University, Dongdaemoon-gu, Seoul 02447, Republic of Korea; Corresponding author.Objectives: This study evaluated the effects of protein-enriched oral nutritional supplementation (ONS) consumption for 12 weeks on muscle mass, muscular strength, and function in middle-aged and elderly women. Design: A single-center, double-blind, randomized controlled trial Participants: This study was conducted with 70 healthy female participants aged 50–80. Intervention and measurements: Participants were instructed to incorporate two daily packs of either the test ONS (Nucare Active, Daesang Wellife Corp., Seoul, Republic of Korea; 200 kcal/pack, 23 g carbohydrate, 6 g fat, and 15 g protein including branched chain amino acids or placebo ONS (200 kcal/pack, 33 g carbohydrate, 8 g fat, and 1 g protein) into their routine for 12 weeks while maintaining their regular lifestyle. The primary outcome was lean body mass (LBM), while secondary outcomes included muscular strength, physical performance ability, inflammatory markers, and body fat mass (FM). Results: Sixty-four participants (33 in the test group, 31 in the placebo group; mean ± SD age, [test] 63.06 ± 5.51 years, [placebo] 63.29 ± 3.28 years, p = 0.839) completed the 12-week protocol. The test group exhibited a higher percentage change in LBM than the placebo group (0.26 % [95%CI: −0.27, 0.78] vs. −0.47 % [95%CI: −0.81, −0.13]; p = 0.020). The placebo group experienced a significant increase in FM (38.15 % [95%CI: 36.62, 39.69] to 38.67 % [95%CI: 37.14, 40.21]; p < 0.01). The difference in the changes in LBM/BMI and FM/BMI between the two groups was also visually distinct. There were no significant differences between the two groups in terms of muscular strength, physical performance ability, or inflammatory markers. Conclusions: Protein-enriched ONS helped maintain LBM and prevent FM gain in middle-aged and elderly females. This suggests its potential role in preventing frailty and musculoskeletal disorders associated with female aging.http://www.sciencedirect.com/science/article/pii/S1279770725000314Oral nutritional supplementsProtein-enriched ONSMuscle functionLean body massBranched chain amino acidSarcopenia |
| spellingShingle | Minji Kang Hyunkyung Rho Minhui Kim Miji Lee Yunsook Lim Jinmann Chon Hyunjung Lim Effectiveness of Protein-enriched oral nutritional supplements on muscle function in middle-aged and elderly women: A randomized controlled trial The Journal of Nutrition, Health and Aging Oral nutritional supplements Protein-enriched ONS Muscle function Lean body mass Branched chain amino acid Sarcopenia |
| title | Effectiveness of Protein-enriched oral nutritional supplements on muscle function in middle-aged and elderly women: A randomized controlled trial |
| title_full | Effectiveness of Protein-enriched oral nutritional supplements on muscle function in middle-aged and elderly women: A randomized controlled trial |
| title_fullStr | Effectiveness of Protein-enriched oral nutritional supplements on muscle function in middle-aged and elderly women: A randomized controlled trial |
| title_full_unstemmed | Effectiveness of Protein-enriched oral nutritional supplements on muscle function in middle-aged and elderly women: A randomized controlled trial |
| title_short | Effectiveness of Protein-enriched oral nutritional supplements on muscle function in middle-aged and elderly women: A randomized controlled trial |
| title_sort | effectiveness of protein enriched oral nutritional supplements on muscle function in middle aged and elderly women a randomized controlled trial |
| topic | Oral nutritional supplements Protein-enriched ONS Muscle function Lean body mass Branched chain amino acid Sarcopenia |
| url | http://www.sciencedirect.com/science/article/pii/S1279770725000314 |
| work_keys_str_mv | AT minjikang effectivenessofproteinenrichedoralnutritionalsupplementsonmusclefunctioninmiddleagedandelderlywomenarandomizedcontrolledtrial AT hyunkyungrho effectivenessofproteinenrichedoralnutritionalsupplementsonmusclefunctioninmiddleagedandelderlywomenarandomizedcontrolledtrial AT minhuikim effectivenessofproteinenrichedoralnutritionalsupplementsonmusclefunctioninmiddleagedandelderlywomenarandomizedcontrolledtrial AT mijilee effectivenessofproteinenrichedoralnutritionalsupplementsonmusclefunctioninmiddleagedandelderlywomenarandomizedcontrolledtrial AT yunsooklim effectivenessofproteinenrichedoralnutritionalsupplementsonmusclefunctioninmiddleagedandelderlywomenarandomizedcontrolledtrial AT jinmannchon effectivenessofproteinenrichedoralnutritionalsupplementsonmusclefunctioninmiddleagedandelderlywomenarandomizedcontrolledtrial AT hyunjunglim effectivenessofproteinenrichedoralnutritionalsupplementsonmusclefunctioninmiddleagedandelderlywomenarandomizedcontrolledtrial |