Skeletal muscle stretching as a mechanotransductive trigger for myokine release: A narrative review
Skeletal muscle functions as an endocrine organ by releasing myokines—cytokines and peptides that mediate systemic physiological adaptations. This review synthesizes evidence establishing mechanical stretching (active/passive) as a potent mechanotransductive stimulus for myokine secretion. Key pathw...
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| Format: | Article |
| Language: | English |
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2025-03-01
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| Series: | Journal of Exercise & Organ Cross Talk |
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| Online Access: | https://www.jeoct.com/article_224366_40b3041b979640235e1bd1ca11daee74.pdf |
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| _version_ | 1849731039571738624 |
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| author | Hossein Shirvani Maryam Naghibzadeh Seyed Ebrahim Hashemi |
| author_facet | Hossein Shirvani Maryam Naghibzadeh Seyed Ebrahim Hashemi |
| author_sort | Hossein Shirvani |
| collection | DOAJ |
| description | Skeletal muscle functions as an endocrine organ by releasing myokines—cytokines and peptides that mediate systemic physiological adaptations. This review synthesizes evidence establishing mechanical stretching (active/passive) as a potent mechanotransductive stimulus for myokine secretion. Key pathways include integrin-mediated signaling, stretch-activated ion channels (Piezo/TRP), and mechanosensitive transcriptional regulators (YAP/TAZ), which activate MAPK, calcium-dependent kinases, and other cascades to modulate myokine gene expression. We highlight stretch-responsive myokines (IL-6, irisin, myostatin, BDNF, SPARC) and their roles in metabolism, tissue repair, and inflammation. Clinical implications for aging, metabolic disease, and rehabilitation are discussed, emphasizing how targeted stretching protocols may harness myokine-mediated benefits in mobility-limited populations. Future research directions include optimizing stretch "dosing" and elucidating tissue-specific myokine actions. |
| format | Article |
| id | doaj-art-9d5d17d08d994b0c94bf2fa66cb22e5e |
| institution | DOAJ |
| issn | 2783-2074 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | JEOCT publisher |
| record_format | Article |
| series | Journal of Exercise & Organ Cross Talk |
| spelling | doaj-art-9d5d17d08d994b0c94bf2fa66cb22e5e2025-08-20T03:08:40ZengJEOCT publisherJournal of Exercise & Organ Cross Talk2783-20742025-03-0151404510.22122/jeoct.2025.532507.1161224366Skeletal muscle stretching as a mechanotransductive trigger for myokine release: A narrative reviewHossein Shirvani0Maryam Naghibzadeh1Seyed Ebrahim Hashemi2Exercise Physiology Research Center, Life style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.Assistant Professor, Department of Sports Science, Faculty of Literature and Humanities, Ilam University, Ilam, Iran.Exercise Physiology Research Center, Life style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.Skeletal muscle functions as an endocrine organ by releasing myokines—cytokines and peptides that mediate systemic physiological adaptations. This review synthesizes evidence establishing mechanical stretching (active/passive) as a potent mechanotransductive stimulus for myokine secretion. Key pathways include integrin-mediated signaling, stretch-activated ion channels (Piezo/TRP), and mechanosensitive transcriptional regulators (YAP/TAZ), which activate MAPK, calcium-dependent kinases, and other cascades to modulate myokine gene expression. We highlight stretch-responsive myokines (IL-6, irisin, myostatin, BDNF, SPARC) and their roles in metabolism, tissue repair, and inflammation. Clinical implications for aging, metabolic disease, and rehabilitation are discussed, emphasizing how targeted stretching protocols may harness myokine-mediated benefits in mobility-limited populations. Future research directions include optimizing stretch "dosing" and elucidating tissue-specific myokine actions.https://www.jeoct.com/article_224366_40b3041b979640235e1bd1ca11daee74.pdfmechanotransductionskeletal muscle stretchmyokinesil-6irisinmyostatinintegrin signaling |
| spellingShingle | Hossein Shirvani Maryam Naghibzadeh Seyed Ebrahim Hashemi Skeletal muscle stretching as a mechanotransductive trigger for myokine release: A narrative review Journal of Exercise & Organ Cross Talk mechanotransduction skeletal muscle stretch myokines il-6 irisin myostatin integrin signaling |
| title | Skeletal muscle stretching as a mechanotransductive trigger for myokine release: A narrative review |
| title_full | Skeletal muscle stretching as a mechanotransductive trigger for myokine release: A narrative review |
| title_fullStr | Skeletal muscle stretching as a mechanotransductive trigger for myokine release: A narrative review |
| title_full_unstemmed | Skeletal muscle stretching as a mechanotransductive trigger for myokine release: A narrative review |
| title_short | Skeletal muscle stretching as a mechanotransductive trigger for myokine release: A narrative review |
| title_sort | skeletal muscle stretching as a mechanotransductive trigger for myokine release a narrative review |
| topic | mechanotransduction skeletal muscle stretch myokines il-6 irisin myostatin integrin signaling |
| url | https://www.jeoct.com/article_224366_40b3041b979640235e1bd1ca11daee74.pdf |
| work_keys_str_mv | AT hosseinshirvani skeletalmusclestretchingasamechanotransductivetriggerformyokinereleaseanarrativereview AT maryamnaghibzadeh skeletalmusclestretchingasamechanotransductivetriggerformyokinereleaseanarrativereview AT seyedebrahimhashemi skeletalmusclestretchingasamechanotransductivetriggerformyokinereleaseanarrativereview |