Skeletal muscle stretching as a mechanotransductive trigger for myokine release: A narrative review
Skeletal muscle functions as an endocrine organ by releasing myokines—cytokines and peptides that mediate systemic physiological adaptations. This review synthesizes evidence establishing mechanical stretching (active/passive) as a potent mechanotransductive stimulus for myokine secretion. Key pathw...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JEOCT publisher
2025-03-01
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| Series: | Journal of Exercise & Organ Cross Talk |
| Subjects: | |
| Online Access: | https://www.jeoct.com/article_224366_40b3041b979640235e1bd1ca11daee74.pdf |
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| Summary: | Skeletal muscle functions as an endocrine organ by releasing myokines—cytokines and peptides that mediate systemic physiological adaptations. This review synthesizes evidence establishing mechanical stretching (active/passive) as a potent mechanotransductive stimulus for myokine secretion. Key pathways include integrin-mediated signaling, stretch-activated ion channels (Piezo/TRP), and mechanosensitive transcriptional regulators (YAP/TAZ), which activate MAPK, calcium-dependent kinases, and other cascades to modulate myokine gene expression. We highlight stretch-responsive myokines (IL-6, irisin, myostatin, BDNF, SPARC) and their roles in metabolism, tissue repair, and inflammation. Clinical implications for aging, metabolic disease, and rehabilitation are discussed, emphasizing how targeted stretching protocols may harness myokine-mediated benefits in mobility-limited populations. Future research directions include optimizing stretch "dosing" and elucidating tissue-specific myokine actions. |
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| ISSN: | 2783-2074 |