Non-Coding RNAs as Critical Modulators of Cholesterol Metabolism in Cancer
Cholesterol metabolism reprogramming helps tumor cells meet their high energy and biosynthetic needs. Many studies link high cholesterol levels to a higher risk of cancers, such as breast, prostate, and colorectal cancer. Dysregulated cholesterol metabolism contributes to cancer development and prog...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/7/1631 |
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| author | Chunyu Zhang Zhiwei Miao Yan Xu Tongguo Shi |
| author_facet | Chunyu Zhang Zhiwei Miao Yan Xu Tongguo Shi |
| author_sort | Chunyu Zhang |
| collection | DOAJ |
| description | Cholesterol metabolism reprogramming helps tumor cells meet their high energy and biosynthetic needs. Many studies link high cholesterol levels to a higher risk of cancers, such as breast, prostate, and colorectal cancer. Dysregulated cholesterol metabolism contributes to cancer development and progression. Various non-coding RNAs (ncRNAs), such as miRNAs, lncRNAs, circRNAs, piRNAs, and tRNAs, are key players in this process. However, systematic reviews of ncRNAs’ functions in cholesterol metabolism and their impact on tumor progression are limited. This review aims to address this gap by summarizing the current understanding of how ncRNAs govern cholesterol metabolism in cancer. We provide a comprehensive overview of cholesterol metabolism reprogramming in tumor progression through its influence on growth, metastasis, drug resistance, and immune evasion. Moreover, we summarize recent advances in understanding how ncRNAs regulate cholesterol metabolism in cancer, highlighting potential therapeutic targets for cancer treatment. |
| format | Article |
| id | doaj-art-9d597da3eeb04f56ab7e2ccfae9e8fbf |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-9d597da3eeb04f56ab7e2ccfae9e8fbf2025-08-20T03:02:48ZengMDPI AGBiomedicines2227-90592025-07-01137163110.3390/biomedicines13071631Non-Coding RNAs as Critical Modulators of Cholesterol Metabolism in CancerChunyu Zhang0Zhiwei Miao1Yan Xu2Tongguo Shi3Department of Gastroenterology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, 77 South Changan Road, Zhangjiagang 215600, ChinaDepartment of Gastroenterology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, 77 South Changan Road, Zhangjiagang 215600, ChinaDepartment of Gastroenterology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, 77 South Changan Road, Zhangjiagang 215600, ChinaJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, 178 East Ganjiang Road, Suzhou 215000, ChinaCholesterol metabolism reprogramming helps tumor cells meet their high energy and biosynthetic needs. Many studies link high cholesterol levels to a higher risk of cancers, such as breast, prostate, and colorectal cancer. Dysregulated cholesterol metabolism contributes to cancer development and progression. Various non-coding RNAs (ncRNAs), such as miRNAs, lncRNAs, circRNAs, piRNAs, and tRNAs, are key players in this process. However, systematic reviews of ncRNAs’ functions in cholesterol metabolism and their impact on tumor progression are limited. This review aims to address this gap by summarizing the current understanding of how ncRNAs govern cholesterol metabolism in cancer. We provide a comprehensive overview of cholesterol metabolism reprogramming in tumor progression through its influence on growth, metastasis, drug resistance, and immune evasion. Moreover, we summarize recent advances in understanding how ncRNAs regulate cholesterol metabolism in cancer, highlighting potential therapeutic targets for cancer treatment.https://www.mdpi.com/2227-9059/13/7/1631cholesterol metabolismnon-coding RNAscancer |
| spellingShingle | Chunyu Zhang Zhiwei Miao Yan Xu Tongguo Shi Non-Coding RNAs as Critical Modulators of Cholesterol Metabolism in Cancer Biomedicines cholesterol metabolism non-coding RNAs cancer |
| title | Non-Coding RNAs as Critical Modulators of Cholesterol Metabolism in Cancer |
| title_full | Non-Coding RNAs as Critical Modulators of Cholesterol Metabolism in Cancer |
| title_fullStr | Non-Coding RNAs as Critical Modulators of Cholesterol Metabolism in Cancer |
| title_full_unstemmed | Non-Coding RNAs as Critical Modulators of Cholesterol Metabolism in Cancer |
| title_short | Non-Coding RNAs as Critical Modulators of Cholesterol Metabolism in Cancer |
| title_sort | non coding rnas as critical modulators of cholesterol metabolism in cancer |
| topic | cholesterol metabolism non-coding RNAs cancer |
| url | https://www.mdpi.com/2227-9059/13/7/1631 |
| work_keys_str_mv | AT chunyuzhang noncodingrnasascriticalmodulatorsofcholesterolmetabolismincancer AT zhiweimiao noncodingrnasascriticalmodulatorsofcholesterolmetabolismincancer AT yanxu noncodingrnasascriticalmodulatorsofcholesterolmetabolismincancer AT tongguoshi noncodingrnasascriticalmodulatorsofcholesterolmetabolismincancer |