Advances in the study of core fucosylation in mammals
Glycosylation is a major posttranslational modification, which involves in the regulation of important physiological functions. Among them, core fucosylation is an α1, 6-linked fucose to N-glycans, which catalyzes by only one glycosyltransferase. This review will focus on core fucosylation in mammal...
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Zhejiang University Press
2021-01-01
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| Series: | 浙江大学学报. 农业与生命科学版 |
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| Online Access: | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2020.03.231 |
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| author | TIAN Yinping YI Wen |
| author_facet | TIAN Yinping YI Wen |
| author_sort | TIAN Yinping |
| collection | DOAJ |
| description | Glycosylation is a major posttranslational modification, which involves in the regulation of important physiological functions. Among them, core fucosylation is an α1, 6-linked fucose to N-glycans, which catalyzes by only one glycosyltransferase. This review will focus on core fucosylation in mammals and the related biological functions. Fucosyltransferase 8 (FUT8) is the sole enzyme responsible for this modification via the addition of L-fucose residue from guanosine diphosphate-β-L-fucose. The crystal structure of human FUT8 provided insight into both catalytic mechanism and substrate recognition. Currently, core fucosylation plays an important role in tumor progression, immune regulation and stem cell differentiation. Moreover, fucose analogues were either the metabolic substitutes or inhibitors of fucosylation. In conclusion, the specific labeling and automatic synthesis of core-fucosylated N-glycans will play an important role in its further study and clinical application. |
| format | Article |
| id | doaj-art-9d5788d6fba44baa9a3fe1a6b76e29be |
| institution | DOAJ |
| issn | 1008-9209 2097-5155 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Zhejiang University Press |
| record_format | Article |
| series | 浙江大学学报. 农业与生命科学版 |
| spelling | doaj-art-9d5788d6fba44baa9a3fe1a6b76e29be2025-08-20T02:47:32ZengZhejiang University Press浙江大学学报. 农业与生命科学版1008-92092097-51552021-01-014711010.3785/j.issn.1008-9209.2020.03.23110089209Advances in the study of core fucosylation in mammalsTIAN YinpingYI WenGlycosylation is a major posttranslational modification, which involves in the regulation of important physiological functions. Among them, core fucosylation is an α1, 6-linked fucose to N-glycans, which catalyzes by only one glycosyltransferase. This review will focus on core fucosylation in mammals and the related biological functions. Fucosyltransferase 8 (FUT8) is the sole enzyme responsible for this modification via the addition of L-fucose residue from guanosine diphosphate-β-L-fucose. The crystal structure of human FUT8 provided insight into both catalytic mechanism and substrate recognition. Currently, core fucosylation plays an important role in tumor progression, immune regulation and stem cell differentiation. Moreover, fucose analogues were either the metabolic substitutes or inhibitors of fucosylation. In conclusion, the specific labeling and automatic synthesis of core-fucosylated N-glycans will play an important role in its further study and clinical application.https://www.academax.com/doi/10.3785/j.issn.1008-9209.2020.03.231fucoseglycosyltransferasecore fucosylationtumorimmunestem cellfucose analogue |
| spellingShingle | TIAN Yinping YI Wen Advances in the study of core fucosylation in mammals 浙江大学学报. 农业与生命科学版 fucose glycosyltransferase core fucosylation tumor immune stem cell fucose analogue |
| title | Advances in the study of core fucosylation in mammals |
| title_full | Advances in the study of core fucosylation in mammals |
| title_fullStr | Advances in the study of core fucosylation in mammals |
| title_full_unstemmed | Advances in the study of core fucosylation in mammals |
| title_short | Advances in the study of core fucosylation in mammals |
| title_sort | advances in the study of core fucosylation in mammals |
| topic | fucose glycosyltransferase core fucosylation tumor immune stem cell fucose analogue |
| url | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2020.03.231 |
| work_keys_str_mv | AT tianyinping advancesinthestudyofcorefucosylationinmammals AT yiwen advancesinthestudyofcorefucosylationinmammals |