Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system

Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system

Abstract Chemokine receptors are critically involved in multiple physiological and pathophysiological processes related to immune response mechanisms. Most chemokine receptors are prototypical GPCRs although some also exhibit naturally-encoded signaling-bias toward β-arrestins (βarrs). C-X-C type ch...

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Main Authors: Shirsha Saha, Fumiya K. Sano, Saloni Sharma, Manisankar Ganguly, Annu Dalal, Sudha Mishra, Divyanshu Tiwari, Hiroaki Akasaka, Takaaki A. Kobayashi, Nabarun Roy, Nashrah Zaidi, Yuzuru Itoh, Rob Leurs, Ramanuj Banerjee, Wataru Shihoya, Osamu Nureki, Arun K. Shukla
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58264-w
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