SARM regulates cell apoptosis and inflammation during Toxoplasma gondii infection through a multistep mechanism

SARM regulates cell apoptosis and inflammation during Toxoplasma gondii infection through a multistep mechanism

Abstract Background The sterile alpha and HEAT/Armadillo motif (SARM) is the fifth Toll-like receptor (TLR) adaptor protein containing the Toll/interleukin-1 receptor (TIR) domain, which is highly enriched in the brain. Toxoplasma gondii (T. gondii) is an obligate intracellular parasitic protozoan t...

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Bibliographic Details
Main Authors: Shumin Gao, Min Gao, Huanhui Du, Lingyu Li, Xudian An, Yongyu Shi, Xiaoyan Wang, Hua Cong, Bing Han, Chunxue Zhou, Huaiyu Zhou
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Parasites & Vectors
Subjects:
SARM
Toxoplasma gondii
Apoptosis
Inflammation
Infection
Online Access:https://doi.org/10.1186/s13071-025-06721-2
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