Association between atherosclerosis and the development of multi-organ pathologies
Atherosclerosis is a chronic inflammatory disease affecting the vascular system, characterised by the accumulation of modified lipoproteins, immune cell aggregation and the development of fibrous tissue within blood vessel walls. As atherosclerosis impacts blood vessels, its adverse effects may mani...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-12-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/20503121241310013 |
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| author | Siarhei A Dabravolski Alexey V Churov Natalia V Elizova Alessio L Ravani Amina E Karimova Vasily N Sukhorukov Alexander N Orekhov |
| author_facet | Siarhei A Dabravolski Alexey V Churov Natalia V Elizova Alessio L Ravani Amina E Karimova Vasily N Sukhorukov Alexander N Orekhov |
| author_sort | Siarhei A Dabravolski |
| collection | DOAJ |
| description | Atherosclerosis is a chronic inflammatory disease affecting the vascular system, characterised by the accumulation of modified lipoproteins, immune cell aggregation and the development of fibrous tissue within blood vessel walls. As atherosclerosis impacts blood vessels, its adverse effects may manifest across various tissues and organs. In this review, we examine the association of atherosclerosis with Alzheimer’s disease, stroke, pancreatic and thyroid dysfunction, kidney stones and chronic kidney diseases. In several cases, the reciprocal causative effect of these diseases on the progression of atherosclerosis is also discussed. Particular attention is given to common risk factors, biomarkers and identified molecular mechanisms linking the pathophysiology of atherosclerosis to the dysfunction of multiple tissues and organs. Understanding the role of atherosclerosis and its associated microenvironmental conditions in the pathology of multi-organ disorders may unveil novel therapeutic avenues for the prevention and treatment of cardiovascular and associated diseases. |
| format | Article |
| id | doaj-art-9d425cfca63f45f6bc3941456baeb2c2 |
| institution | OA Journals |
| issn | 2050-3121 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj-art-9d425cfca63f45f6bc3941456baeb2c22025-08-20T02:31:59ZengSAGE PublishingSAGE Open Medicine2050-31212024-12-011210.1177/20503121241310013Association between atherosclerosis and the development of multi-organ pathologiesSiarhei A Dabravolski0Alexey V Churov1Natalia V Elizova2Alessio L Ravani3Amina E Karimova4Vasily N Sukhorukov5Alexander N Orekhov6Department of Biotechnology Engineering, Braude Academic College of Engineering, Karmiel, IsraelPirogov Russian National Research Medical University, Russia Gerontology Clinical Research Centre, Institute on Ageing Research, Russian Federation, Moscow, RussiaInstitute of General Pathology and Pathophysiology, Moscow, RussiaInstitute for Atherosclerosis Research, Moscow, RussiaFaculty of Biology and Biotechnology, National Research University Higher School of Economics, Moscow, RussiaInstitute of Human Morphology, Petrovsky Russian National Centre of Surgery, Moscow, RussiaInstitute of General Pathology and Pathophysiology, Moscow, RussiaAtherosclerosis is a chronic inflammatory disease affecting the vascular system, characterised by the accumulation of modified lipoproteins, immune cell aggregation and the development of fibrous tissue within blood vessel walls. As atherosclerosis impacts blood vessels, its adverse effects may manifest across various tissues and organs. In this review, we examine the association of atherosclerosis with Alzheimer’s disease, stroke, pancreatic and thyroid dysfunction, kidney stones and chronic kidney diseases. In several cases, the reciprocal causative effect of these diseases on the progression of atherosclerosis is also discussed. Particular attention is given to common risk factors, biomarkers and identified molecular mechanisms linking the pathophysiology of atherosclerosis to the dysfunction of multiple tissues and organs. Understanding the role of atherosclerosis and its associated microenvironmental conditions in the pathology of multi-organ disorders may unveil novel therapeutic avenues for the prevention and treatment of cardiovascular and associated diseases.https://doi.org/10.1177/20503121241310013 |
| spellingShingle | Siarhei A Dabravolski Alexey V Churov Natalia V Elizova Alessio L Ravani Amina E Karimova Vasily N Sukhorukov Alexander N Orekhov Association between atherosclerosis and the development of multi-organ pathologies SAGE Open Medicine |
| title | Association between atherosclerosis and the development of multi-organ pathologies |
| title_full | Association between atherosclerosis and the development of multi-organ pathologies |
| title_fullStr | Association between atherosclerosis and the development of multi-organ pathologies |
| title_full_unstemmed | Association between atherosclerosis and the development of multi-organ pathologies |
| title_short | Association between atherosclerosis and the development of multi-organ pathologies |
| title_sort | association between atherosclerosis and the development of multi organ pathologies |
| url | https://doi.org/10.1177/20503121241310013 |
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