Streptococcus pyogenes emm Type 3.93 Emergence, the Netherlands and England
A global increase in the incidence of invasive group A Streptococcus (iGAS) infections was observed after lifting of COVID-19 related restrictions in 2022, and type M1UK dominated in many countries. After seasonal declines in iGAS incidence during the summer of 2023, simultaneous, rapid expansion o...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2025-02-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/31/2/24-0880_article |
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| author | Matthew A. Davies Brechje de Gier Rebecca L. Guy Juliana Coelho Alje P. van Dam Robin van Houdt Sébastien Matamoros Marit van den Berg Patrick E. Habermehl Kartyk Moganeradj Yan Ryan Steve Platt Henry Hearn Eleanor Blakey Darren Chooneea Bart J.M. Vlaminckx Theresa Lamagni Nina M. van Sorge |
| author_facet | Matthew A. Davies Brechje de Gier Rebecca L. Guy Juliana Coelho Alje P. van Dam Robin van Houdt Sébastien Matamoros Marit van den Berg Patrick E. Habermehl Kartyk Moganeradj Yan Ryan Steve Platt Henry Hearn Eleanor Blakey Darren Chooneea Bart J.M. Vlaminckx Theresa Lamagni Nina M. van Sorge |
| author_sort | Matthew A. Davies |
| collection | DOAJ |
| description |
A global increase in the incidence of invasive group A Streptococcus (iGAS) infections was observed after lifting of COVID-19 related restrictions in 2022, and type M1UK dominated in many countries. After seasonal declines in iGAS incidence during the summer of 2023, simultaneous, rapid expansion of a previously rare emm type 3.93 was seen beginning in November, increasing to 20% of all cases in England and 60% of all cases in the Netherlands within 4 months. emm3.93 was associated with iGAS in children 6–17 years of age and with increased risk for pneumonia or pleural empyema and meningitis in both countries. No excess risk of death was identified for emm3.93 compared with other types. Genomic analysis of historic and contemporary emm3.93 isolates revealed the emergence of 3 new clades with a potentially advantageous genomic configuration. Our findings demonstrate the value of molecular surveillance, including long-read sequencing, in identifying clinical and public health threats.
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| format | Article |
| id | doaj-art-9d3fbcf2ec2b44beaab9f490070c1fab |
| institution | DOAJ |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-9d3fbcf2ec2b44beaab9f490070c1fab2025-08-20T03:01:22ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-02-0131222923610.3201/eid3102.240880Streptococcus pyogenes emm Type 3.93 Emergence, the Netherlands and EnglandMatthew A. DaviesBrechje de GierRebecca L. GuyJuliana CoelhoAlje P. van DamRobin van HoudtSébastien MatamorosMarit van den BergPatrick E. HabermehlKartyk MoganeradjYan RyanSteve PlattHenry HearnEleanor BlakeyDarren ChooneeaBart J.M. VlaminckxTheresa LamagniNina M. van Sorge A global increase in the incidence of invasive group A Streptococcus (iGAS) infections was observed after lifting of COVID-19 related restrictions in 2022, and type M1UK dominated in many countries. After seasonal declines in iGAS incidence during the summer of 2023, simultaneous, rapid expansion of a previously rare emm type 3.93 was seen beginning in November, increasing to 20% of all cases in England and 60% of all cases in the Netherlands within 4 months. emm3.93 was associated with iGAS in children 6–17 years of age and with increased risk for pneumonia or pleural empyema and meningitis in both countries. No excess risk of death was identified for emm3.93 compared with other types. Genomic analysis of historic and contemporary emm3.93 isolates revealed the emergence of 3 new clades with a potentially advantageous genomic configuration. Our findings demonstrate the value of molecular surveillance, including long-read sequencing, in identifying clinical and public health threats. https://wwwnc.cdc.gov/eid/article/31/2/24-0880_articleStreptococcus pyogenesstreptococcipneumoniameningitis/encephalitisbacteriaepidemiology |
| spellingShingle | Matthew A. Davies Brechje de Gier Rebecca L. Guy Juliana Coelho Alje P. van Dam Robin van Houdt Sébastien Matamoros Marit van den Berg Patrick E. Habermehl Kartyk Moganeradj Yan Ryan Steve Platt Henry Hearn Eleanor Blakey Darren Chooneea Bart J.M. Vlaminckx Theresa Lamagni Nina M. van Sorge Streptococcus pyogenes emm Type 3.93 Emergence, the Netherlands and England Emerging Infectious Diseases Streptococcus pyogenes streptococci pneumonia meningitis/encephalitis bacteria epidemiology |
| title | Streptococcus pyogenes emm Type 3.93 Emergence, the Netherlands and England |
| title_full | Streptococcus pyogenes emm Type 3.93 Emergence, the Netherlands and England |
| title_fullStr | Streptococcus pyogenes emm Type 3.93 Emergence, the Netherlands and England |
| title_full_unstemmed | Streptococcus pyogenes emm Type 3.93 Emergence, the Netherlands and England |
| title_short | Streptococcus pyogenes emm Type 3.93 Emergence, the Netherlands and England |
| title_sort | streptococcus pyogenes emm type 3 93 emergence the netherlands and england |
| topic | Streptococcus pyogenes streptococci pneumonia meningitis/encephalitis bacteria epidemiology |
| url | https://wwwnc.cdc.gov/eid/article/31/2/24-0880_article |
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