Dissemination of Tylosin Residues in the Poultry Environment: Evaluating Litter and Droppings as Sources of Risk
<b>Introduction:</b> Tylosin, a veterinary antimicrobial belonging to the macrolide family, is commonly used in the poultry industry. Residues generated from its use can be present in the litter and droppings of treated birds. Due to the diverse uses of poultry byproducts, such as fertil...
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MDPI AG
2025-05-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/14/5/477 |
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| author | María Belén Vargas Ignacia Soto Francisco Mena Paula Cortés Ekaterina Pokrant Lina Trincado Matías Maturana Andrés Flores Aldo Maddaleno Lisette Lapierre Javiera Cornejo |
| author_facet | María Belén Vargas Ignacia Soto Francisco Mena Paula Cortés Ekaterina Pokrant Lina Trincado Matías Maturana Andrés Flores Aldo Maddaleno Lisette Lapierre Javiera Cornejo |
| author_sort | María Belén Vargas |
| collection | DOAJ |
| description | <b>Introduction:</b> Tylosin, a veterinary antimicrobial belonging to the macrolide family, is commonly used in the poultry industry. Residues generated from its use can be present in the litter and droppings of treated birds. Due to the diverse uses of poultry byproducts, such as fertilizing agricultural soils or incorporation into the diets of other animal species, there is a risk to public health, as the presence of antimicrobial residues favors the development of antimicrobial resistance, which is a global problem. <b>Objective:</b> This study aimed to evaluate the dissemination of tylosin residues from the litter and droppings of treated birds and untreated birds in a controlled broiler environment. <b>Methods:</b> Bird droppings and litter samples were collected and analyzed using HPLC-MS/MS to detect and quantify tylosin residues. <b>Results:</b> The residue concentrations detected in the dropping matrix only exceeded the Limits of Quantification (LOQ = 4 µg kg<sup>−1</sup>) in the treated group. The litter matrix had statistically significant differences between the study groups. The persistence of tylosin residues in the litter of birds at day 42 was 290.16 µg kg<sup>−1</sup> in the treated group (A) and 9.35 µg kg<sup>−1</sup> in the adjacent untreated group (B.1). <b>Conclusions:</b> The results indicate that exposure distance influences tylosin residue dissemination. |
| format | Article |
| id | doaj-art-9d3ace4cd19c41fba3b5df58a34e5cf4 |
| institution | OA Journals |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-9d3ace4cd19c41fba3b5df58a34e5cf42025-08-20T01:56:20ZengMDPI AGAntibiotics2079-63822025-05-0114547710.3390/antibiotics14050477Dissemination of Tylosin Residues in the Poultry Environment: Evaluating Litter and Droppings as Sources of RiskMaría Belén Vargas0Ignacia Soto1Francisco Mena2Paula Cortés3Ekaterina Pokrant4Lina Trincado5Matías Maturana6Andrés Flores7Aldo Maddaleno8Lisette Lapierre9Javiera Cornejo10Laboratory of Food Safety, Department of Preventive Animal Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Santiago 8820808, ChileLaboratory of Veterinary Pharmacology (FARMAVET), Faculty of Veterinary and Animal Sciences, University of Chile, Santiago 8820808, ChileLaboratory of Food Safety, Department of Preventive Animal Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Santiago 8820808, ChileDoctorate Program of Forestry, Agriculture, and Veterinary Sciences (DCSAV), University of Chile, Santiago 8820808, ChileLaboratory of Food Safety, Department of Preventive Animal Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Santiago 8820808, ChileDoctorate Program of Forestry, Agriculture, and Veterinary Sciences (DCSAV), University of Chile, Santiago 8820808, ChileLaboratory of Veterinary Pharmacology (FARMAVET), Faculty of Veterinary and Animal Sciences, University of Chile, Santiago 8820808, ChileLaboratory of Veterinary Pharmacology (FARMAVET), Faculty of Veterinary and Animal Sciences, University of Chile, Santiago 8820808, ChileLaboratory of Veterinary Pharmacology (FARMAVET), Faculty of Veterinary and Animal Sciences, University of Chile, Santiago 8820808, ChileLaboratory of Bacterial Pathogens Diagnostic and Antimicrobial Resistance, Department of Preventive Animal Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Santiago 8820808, ChileLaboratory of Food Safety, Department of Preventive Animal Medicine, Faculty of Veterinary and Animal Sciences, University of Chile, Santiago 8820808, Chile<b>Introduction:</b> Tylosin, a veterinary antimicrobial belonging to the macrolide family, is commonly used in the poultry industry. Residues generated from its use can be present in the litter and droppings of treated birds. Due to the diverse uses of poultry byproducts, such as fertilizing agricultural soils or incorporation into the diets of other animal species, there is a risk to public health, as the presence of antimicrobial residues favors the development of antimicrobial resistance, which is a global problem. <b>Objective:</b> This study aimed to evaluate the dissemination of tylosin residues from the litter and droppings of treated birds and untreated birds in a controlled broiler environment. <b>Methods:</b> Bird droppings and litter samples were collected and analyzed using HPLC-MS/MS to detect and quantify tylosin residues. <b>Results:</b> The residue concentrations detected in the dropping matrix only exceeded the Limits of Quantification (LOQ = 4 µg kg<sup>−1</sup>) in the treated group. The litter matrix had statistically significant differences between the study groups. The persistence of tylosin residues in the litter of birds at day 42 was 290.16 µg kg<sup>−1</sup> in the treated group (A) and 9.35 µg kg<sup>−1</sup> in the adjacent untreated group (B.1). <b>Conclusions:</b> The results indicate that exposure distance influences tylosin residue dissemination.https://www.mdpi.com/2079-6382/14/5/477tylosinresiduesdisseminationpoultrylitterdropping |
| spellingShingle | María Belén Vargas Ignacia Soto Francisco Mena Paula Cortés Ekaterina Pokrant Lina Trincado Matías Maturana Andrés Flores Aldo Maddaleno Lisette Lapierre Javiera Cornejo Dissemination of Tylosin Residues in the Poultry Environment: Evaluating Litter and Droppings as Sources of Risk Antibiotics tylosin residues dissemination poultry litter dropping |
| title | Dissemination of Tylosin Residues in the Poultry Environment: Evaluating Litter and Droppings as Sources of Risk |
| title_full | Dissemination of Tylosin Residues in the Poultry Environment: Evaluating Litter and Droppings as Sources of Risk |
| title_fullStr | Dissemination of Tylosin Residues in the Poultry Environment: Evaluating Litter and Droppings as Sources of Risk |
| title_full_unstemmed | Dissemination of Tylosin Residues in the Poultry Environment: Evaluating Litter and Droppings as Sources of Risk |
| title_short | Dissemination of Tylosin Residues in the Poultry Environment: Evaluating Litter and Droppings as Sources of Risk |
| title_sort | dissemination of tylosin residues in the poultry environment evaluating litter and droppings as sources of risk |
| topic | tylosin residues dissemination poultry litter dropping |
| url | https://www.mdpi.com/2079-6382/14/5/477 |
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