Evaluation of Bone Disease in Chronic Kidney Disease and Post-Transplant Patients Using Dual X-Ray Absorptiometry and Bone Biomarkers – A Single-Center Study
Background: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a common complication in CKD patients and often persists after renal transplantation. Dual-energy X-ray absorptiometry (DXA) assesses bone mineral density (BMD), while bone biomarkers provide insight into bone turnover. This...
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Medsci Publications
2025-04-01
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| Series: | National Journal of Medical Research |
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| Online Access: | https://njmr.in/index.php/file/article/view/1082 |
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| author | Gaurav Vohra Nagamahendran Rajendran Anju Kumari |
| author_facet | Gaurav Vohra Nagamahendran Rajendran Anju Kumari |
| author_sort | Gaurav Vohra |
| collection | DOAJ |
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Background: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a common complication in CKD patients and often persists after renal transplantation. Dual-energy X-ray absorptiometry (DXA) assesses bone mineral density (BMD), while bone biomarkers provide insight into bone turnover. This study evaluates bone disease in CKD and post-transplant patients using DXA and bone biomarkers to assess changes in BMD and metabolic bone parameters post-transplantation.
Methods: This observational study included CKD patients and post-transplant recipients. BMD was measured at the spine, femur, and radius using DXA. Bone turnover markers, including parathyroid hormone (PTH), vitamin D3, calcium, phosphorus, and osteocalcin, were analyzed. Comparative statistical analysis was performed to assess differences between CKD and post-transplant groups.
Results: Mean BMD at the femur and radius did not differ significantly between CKD and post-transplant patients (p > 0.05). Osteopenia was the most prevalent bone abnormality in both groups. No significant correlation was found between calcium, phosphorus, and PTH levels, but PTH and osteocalcin were significantly associated (p = 0.02). A significant relationship was also found between BMD at the radius and T-score at the spine (p = 0.008).
Conclusion: Bone disease persists in CKD and post-transplant patients, highlighting the need for long-term monitoring and tailored interventions.
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| format | Article |
| id | doaj-art-9d390dbd663842e38851e59050a2777e |
| institution | DOAJ |
| issn | 2249-4995 2277-8810 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Medsci Publications |
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| series | National Journal of Medical Research |
| spelling | doaj-art-9d390dbd663842e38851e59050a2777e2025-08-20T03:04:38ZengMedsci PublicationsNational Journal of Medical Research2249-49952277-88102025-04-01150210.55489/njmr.150220251082Evaluation of Bone Disease in Chronic Kidney Disease and Post-Transplant Patients Using Dual X-Ray Absorptiometry and Bone Biomarkers – A Single-Center StudyGaurav Vohra0Nagamahendran Rajendran1https://orcid.org/0000-0002-9854-7236Anju Kumari2Department of Nephrology, INM, INHS Sandhani, Mumbai, IndiaDepartment of General Surgery, 15 Air Force Hospital, Jaisalmer, Rajasthan, IndiaDepartment of Ophthalmologist, Laxmi Eye Hospital, Panvel, Mumbai Background: Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a common complication in CKD patients and often persists after renal transplantation. Dual-energy X-ray absorptiometry (DXA) assesses bone mineral density (BMD), while bone biomarkers provide insight into bone turnover. This study evaluates bone disease in CKD and post-transplant patients using DXA and bone biomarkers to assess changes in BMD and metabolic bone parameters post-transplantation. Methods: This observational study included CKD patients and post-transplant recipients. BMD was measured at the spine, femur, and radius using DXA. Bone turnover markers, including parathyroid hormone (PTH), vitamin D3, calcium, phosphorus, and osteocalcin, were analyzed. Comparative statistical analysis was performed to assess differences between CKD and post-transplant groups. Results: Mean BMD at the femur and radius did not differ significantly between CKD and post-transplant patients (p > 0.05). Osteopenia was the most prevalent bone abnormality in both groups. No significant correlation was found between calcium, phosphorus, and PTH levels, but PTH and osteocalcin were significantly associated (p = 0.02). A significant relationship was also found between BMD at the radius and T-score at the spine (p = 0.008). Conclusion: Bone disease persists in CKD and post-transplant patients, highlighting the need for long-term monitoring and tailored interventions. https://njmr.in/index.php/file/article/view/1082Chronic kidney diseaserenal transplantationbone mineral densityDXA scanosteopeniaosteoporosis |
| spellingShingle | Gaurav Vohra Nagamahendran Rajendran Anju Kumari Evaluation of Bone Disease in Chronic Kidney Disease and Post-Transplant Patients Using Dual X-Ray Absorptiometry and Bone Biomarkers – A Single-Center Study National Journal of Medical Research Chronic kidney disease renal transplantation bone mineral density DXA scan osteopenia osteoporosis |
| title | Evaluation of Bone Disease in Chronic Kidney Disease and Post-Transplant Patients Using Dual X-Ray Absorptiometry and Bone Biomarkers – A Single-Center Study |
| title_full | Evaluation of Bone Disease in Chronic Kidney Disease and Post-Transplant Patients Using Dual X-Ray Absorptiometry and Bone Biomarkers – A Single-Center Study |
| title_fullStr | Evaluation of Bone Disease in Chronic Kidney Disease and Post-Transplant Patients Using Dual X-Ray Absorptiometry and Bone Biomarkers – A Single-Center Study |
| title_full_unstemmed | Evaluation of Bone Disease in Chronic Kidney Disease and Post-Transplant Patients Using Dual X-Ray Absorptiometry and Bone Biomarkers – A Single-Center Study |
| title_short | Evaluation of Bone Disease in Chronic Kidney Disease and Post-Transplant Patients Using Dual X-Ray Absorptiometry and Bone Biomarkers – A Single-Center Study |
| title_sort | evaluation of bone disease in chronic kidney disease and post transplant patients using dual x ray absorptiometry and bone biomarkers a single center study |
| topic | Chronic kidney disease renal transplantation bone mineral density DXA scan osteopenia osteoporosis |
| url | https://njmr.in/index.php/file/article/view/1082 |
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