The relation between cerebral small vessel function and white matter microstructure in monogenic and sporadic small vessel disease - the ZOOM@SVDs study
In cerebral small vessel disease (cSVD), vascular dysfunction has been associated with cSVD-lesions across the brain. Here we further explore the relation between vascular dysfunction and cSVD-related brain injury. We tested two hypotheses: (1) that complementary measures of abnormal small vessel fu...
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Elsevier
2025-01-01
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| Series: | Cerebral Circulation - Cognition and Behavior |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666245025000078 |
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| author | Naomi Vlegels Hilde van den Brink Anna Kopczak Tine Arts Stanley D.T. Pham Jeroen C.W. Siero Benno Gesierich Alberto De Luca Marco Duering Jaco J.M. Zwanenburg Martin Dichgans Geert Jan Biessels |
| author_facet | Naomi Vlegels Hilde van den Brink Anna Kopczak Tine Arts Stanley D.T. Pham Jeroen C.W. Siero Benno Gesierich Alberto De Luca Marco Duering Jaco J.M. Zwanenburg Martin Dichgans Geert Jan Biessels |
| author_sort | Naomi Vlegels |
| collection | DOAJ |
| description | In cerebral small vessel disease (cSVD), vascular dysfunction has been associated with cSVD-lesions across the brain. Here we further explore the relation between vascular dysfunction and cSVD-related brain injury. We tested two hypotheses: (1) that complementary measures of abnormal small vessel function relate to decreased white matter integrity, and (2) that local variance in vascular dysfunction relates to local variance in white matter integrity within individual patients.We included 23 patients with monogenic cSVD (i.e. CADASIL) and 46 patients with sporadic cSVD. With whole-brain analyses, we tested if small vessel flow velocity and reactivity measures from 7T-MRI were associated with global peak-width-of-skeletonized-mean-diffusivity (PSMD). We also tested voxel-wise correlations between reactivity to hypercapnia and mean diffusivity (MD) in white matter.Whole-brain analyses showed a negative association between blood flow velocity and PSMD for the perforating arteries in the centrum semiovale in CADASIL (p = 0.04) and in the basal ganglia in sporadic cSVD (p = 0.002). Global white matter reactivity to hypercapnia was not associated with PSMD. Within patients, both in CADASIL and sporadic cSVD, we observed significant voxel-wise negative correlations for endothelial-independent vascular reactivity and MD in the white matter.These findings confirm our hypothesis that small vessel dysfunction in patients with cSVD is associated with microstructural white matter alterations, also at voxel level. The latter may reflect a direct relationship between local small vessel dysfunction and tissue injury. |
| format | Article |
| id | doaj-art-9d388090afd04bd18f6f7a7aeee15481 |
| institution | OA Journals |
| issn | 2666-2450 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cerebral Circulation - Cognition and Behavior |
| spelling | doaj-art-9d388090afd04bd18f6f7a7aeee154812025-08-20T02:10:17ZengElsevierCerebral Circulation - Cognition and Behavior2666-24502025-01-01810038310.1016/j.cccb.2025.100383The relation between cerebral small vessel function and white matter microstructure in monogenic and sporadic small vessel disease - the ZOOM@SVDs studyNaomi Vlegels0Hilde van den Brink1Anna Kopczak2Tine Arts3Stanley D.T. Pham4Jeroen C.W. Siero5Benno Gesierich6Alberto De Luca7Marco Duering8Jaco J.M. Zwanenburg9Martin Dichgans10Geert Jan Biessels11Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, GermanyTranslational Neuroimaging Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht, The NetherlandsTranslational Neuroimaging Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht, The NetherlandsTranslational Neuroimaging Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands; Spinoza Centre for Neuroimaging Amsterdam, Amsterdam, The NetherlandsInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany; Medical Image Analysis Center (MIAC) and Department of Biomedical Engineering, University of Basel, Basel, SwitzerlandDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Translational Neuroimaging Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands; Image Sciences Institute, Division Imaging and Oncology, University Medical Center Utrecht, Utrecht, The NetherlandsInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany; Medical Image Analysis Center (MIAC) and Department of Biomedical Engineering, University of Basel, Basel, SwitzerlandTranslational Neuroimaging Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht, The NetherlandsInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; German Center for Neurodegenerative Disease (DZNE), Munich, GermanyDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Corresponding author: Department of Neurology and Neurosurgery, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3508 GA, The Netherlands.In cerebral small vessel disease (cSVD), vascular dysfunction has been associated with cSVD-lesions across the brain. Here we further explore the relation between vascular dysfunction and cSVD-related brain injury. We tested two hypotheses: (1) that complementary measures of abnormal small vessel function relate to decreased white matter integrity, and (2) that local variance in vascular dysfunction relates to local variance in white matter integrity within individual patients.We included 23 patients with monogenic cSVD (i.e. CADASIL) and 46 patients with sporadic cSVD. With whole-brain analyses, we tested if small vessel flow velocity and reactivity measures from 7T-MRI were associated with global peak-width-of-skeletonized-mean-diffusivity (PSMD). We also tested voxel-wise correlations between reactivity to hypercapnia and mean diffusivity (MD) in white matter.Whole-brain analyses showed a negative association between blood flow velocity and PSMD for the perforating arteries in the centrum semiovale in CADASIL (p = 0.04) and in the basal ganglia in sporadic cSVD (p = 0.002). Global white matter reactivity to hypercapnia was not associated with PSMD. Within patients, both in CADASIL and sporadic cSVD, we observed significant voxel-wise negative correlations for endothelial-independent vascular reactivity and MD in the white matter.These findings confirm our hypothesis that small vessel dysfunction in patients with cSVD is associated with microstructural white matter alterations, also at voxel level. The latter may reflect a direct relationship between local small vessel dysfunction and tissue injury.http://www.sciencedirect.com/science/article/pii/S2666245025000078CADASILCerebral small vessel diseaseSmall vessel functionUltra-high field strength MRIWhite matter microstructure |
| spellingShingle | Naomi Vlegels Hilde van den Brink Anna Kopczak Tine Arts Stanley D.T. Pham Jeroen C.W. Siero Benno Gesierich Alberto De Luca Marco Duering Jaco J.M. Zwanenburg Martin Dichgans Geert Jan Biessels The relation between cerebral small vessel function and white matter microstructure in monogenic and sporadic small vessel disease - the ZOOM@SVDs study Cerebral Circulation - Cognition and Behavior CADASIL Cerebral small vessel disease Small vessel function Ultra-high field strength MRI White matter microstructure |
| title | The relation between cerebral small vessel function and white matter microstructure in monogenic and sporadic small vessel disease - the ZOOM@SVDs study |
| title_full | The relation between cerebral small vessel function and white matter microstructure in monogenic and sporadic small vessel disease - the ZOOM@SVDs study |
| title_fullStr | The relation between cerebral small vessel function and white matter microstructure in monogenic and sporadic small vessel disease - the ZOOM@SVDs study |
| title_full_unstemmed | The relation between cerebral small vessel function and white matter microstructure in monogenic and sporadic small vessel disease - the ZOOM@SVDs study |
| title_short | The relation between cerebral small vessel function and white matter microstructure in monogenic and sporadic small vessel disease - the ZOOM@SVDs study |
| title_sort | relation between cerebral small vessel function and white matter microstructure in monogenic and sporadic small vessel disease the zoom svds study |
| topic | CADASIL Cerebral small vessel disease Small vessel function Ultra-high field strength MRI White matter microstructure |
| url | http://www.sciencedirect.com/science/article/pii/S2666245025000078 |
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