Key indicators for guiding tocilizumab therapy to prevent orbital decompression surgery in hormone-resistant dysthyroid optic neuropathy

Key indicators for guiding tocilizumab therapy to prevent orbital decompression surgery in hormone-resistant dysthyroid optic neuropathy

IntroductionTocilizumab (TCZ) has been demonstrated to be effective in treating thyroid-associated ophthalmopathy (TAO); however, its efficacy in hormone-resistant dysthyroid optic neuropathy (DON) remains unclear. This study aims to identify baseline and post-treatment indicators that can predict t...

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Bibliographic Details
Main Authors: Wenjun Shu, Mingxu Yan, Lu Gan, Lu Li, Hongyue Tao, Zhiyu Peng, Jinghan Wang, Xiaofeng Li, Xintong Lin, Haifeng Chen, Jie Guo, Kang Xue, Hongguang Cui, Heng Lou, Binbin Xu, Jinwei Cheng, Hongying Ye, Yiming Li, Jiang Qian, Rui Zhang, Ruiqi Ma, Fangfang Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
magnetic resonance imaging
optic neuropathy
thyroid-associated ophthalmopathy
thyroid-stimulating hormone receptor antibody
tocilizumab
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1556742/full
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