Correlation of melatonin and TNF-α levels with characteristics of sleep in patients with rheumatoid arthritis
Specific immune and neuroendocrine factors are considered in the pathogenic mechanisms of sleep disorders in RA. The aim was to investigate the nature of the correlation between sleep disorders and levels of serum melatonin and TNF-α in RA patients. Methods and results. 105 patients and 30 hea...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2015-02-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/39213/35408 |
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| author | Yu. K. Sikalo M. A. Stanislavchuk |
| author_facet | Yu. K. Sikalo M. A. Stanislavchuk |
| author_sort | Yu. K. Sikalo |
| collection | DOAJ |
| description | Specific immune and neuroendocrine factors are considered in the pathogenic mechanisms of sleep disorders in RA.
The aim was to investigate the nature of the correlation between sleep disorders and levels of serum melatonin and TNF-α in RA patients.
Methods and results. 105 patients and 30 healthy control subjects were examined in the study.
Investigation of sleep disorders was conducted by semi-structured clinical interview using the Insomnia severity index (ISI) and with the visual analogue scale (VAS) of sleep disorders. It was found significant differences in the metabolism of melatonin and TNF-α in healthy and RA patients with different variants of insomnia (p <0.01). Differences between the levels of TNF-α and all variants of insomnia (p <0.05) were identified.
Conclusion. The lack of a direct relations between melatonin and insomnia in patients with RA indicates complex multifactorial nature of sleep disorders in this pathology. |
| format | Article |
| id | doaj-art-9d361b3426db4e19b34f75fa00957fb4 |
| institution | OA Journals |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2015-02-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-9d361b3426db4e19b34f75fa00957fb42025-08-20T02:20:19ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102015-02-0115558http://dx.doi.org/10.14739/2310-1210.2015.1.39213Correlation of melatonin and TNF-α levels with characteristics of sleep in patients with rheumatoid arthritisYu. K. SikaloM. A. StanislavchukSpecific immune and neuroendocrine factors are considered in the pathogenic mechanisms of sleep disorders in RA. The aim was to investigate the nature of the correlation between sleep disorders and levels of serum melatonin and TNF-α in RA patients. Methods and results. 105 patients and 30 healthy control subjects were examined in the study. Investigation of sleep disorders was conducted by semi-structured clinical interview using the Insomnia severity index (ISI) and with the visual analogue scale (VAS) of sleep disorders. It was found significant differences in the metabolism of melatonin and TNF-α in healthy and RA patients with different variants of insomnia (p <0.01). Differences between the levels of TNF-α and all variants of insomnia (p <0.05) were identified. Conclusion. The lack of a direct relations between melatonin and insomnia in patients with RA indicates complex multifactorial nature of sleep disorders in this pathology.http://zmj.zsmu.edu.ua/article/view/39213/35408MelatoninTumor Necrosis Factor-alphaSleep DisordersRheumatoid Arthritis |
| spellingShingle | Yu. K. Sikalo M. A. Stanislavchuk Correlation of melatonin and TNF-α levels with characteristics of sleep in patients with rheumatoid arthritis Zaporožskij Medicinskij Žurnal Melatonin Tumor Necrosis Factor-alpha Sleep Disorders Rheumatoid Arthritis |
| title | Correlation of melatonin and TNF-α levels with characteristics of sleep in patients with rheumatoid arthritis |
| title_full | Correlation of melatonin and TNF-α levels with characteristics of sleep in patients with rheumatoid arthritis |
| title_fullStr | Correlation of melatonin and TNF-α levels with characteristics of sleep in patients with rheumatoid arthritis |
| title_full_unstemmed | Correlation of melatonin and TNF-α levels with characteristics of sleep in patients with rheumatoid arthritis |
| title_short | Correlation of melatonin and TNF-α levels with characteristics of sleep in patients with rheumatoid arthritis |
| title_sort | correlation of melatonin and tnf α levels with characteristics of sleep in patients with rheumatoid arthritis |
| topic | Melatonin Tumor Necrosis Factor-alpha Sleep Disorders Rheumatoid Arthritis |
| url | http://zmj.zsmu.edu.ua/article/view/39213/35408 |
| work_keys_str_mv | AT yuksikalo correlationofmelatoninandtnfalevelswithcharacteristicsofsleepinpatientswithrheumatoidarthritis AT mastanislavchuk correlationofmelatoninandtnfalevelswithcharacteristicsofsleepinpatientswithrheumatoidarthritis |