Discovery of a novel polymyxin adjuvant against multidrug-resistant gram-negative bacteria through oxidative stress modulation

Discovery of a novel polymyxin adjuvant against multidrug-resistant gram-negative bacteria through oxidative stress modulation

Antibiotic adjuvants offer a promising strategy for restoring antibiotic sensitivity, expanding antibacterial spectra, and reducing required dosages. Previously, compound 15 was identified as a potential adjuvant for Polymyxin B (PB) against multidrug-resistant (MDR) Pseudomonas aeruginosa DK2; howe...

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Bibliographic Details
Main Authors: Taotao Lu, Hongguang Han, Chaohui Wu, Qian Li, Hongyan Hu, Wenwen Liu, Donglei Shi, Feifei Chen, Lefu Lan, Jian Li, Shihao Song, Baoli Li
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Multidrug resistance
Gram-negative bacteria
Niclosamide
Drug repurposing
Polymyxin B
Adjuvant
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525000280
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