Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Diseases: Literature Review
The pathogenesis of inflammatory bowel diseases still remains unclear nowadays. Genetic disposition, impaired immune regulation, disturbance in intestinal microbiota composition, exposure to environmental factors are associated with the development of inflammation in intestinal mucosa and increased...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2024-05-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/3448 |
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| author | Anatoly I. Khavkin Andrew V. Nalyotov Dmitry I. Masyuta Ravil F. Makhmutov |
| author_facet | Anatoly I. Khavkin Andrew V. Nalyotov Dmitry I. Masyuta Ravil F. Makhmutov |
| author_sort | Anatoly I. Khavkin |
| collection | DOAJ |
| description | The pathogenesis of inflammatory bowel diseases still remains unclear nowadays. Genetic disposition, impaired immune regulation, disturbance in intestinal microbiota composition, exposure to environmental factors are associated with the development of inflammation in intestinal mucosa and increased epithelial penetrance that define disease's development and progression. There is a theory in scientific literature that vitamin D deficiency (among other environmental factors) increases the risk of inflammatory bowel disease. However, the role of vitamin D in the development of gastrointestinal tract diseases remains poorly studied. This article presents current data on the vitamin D effect on the intestinal mucosa barrier function, on the immune system and on the intestinal microbiota in the context of inflammatory bowel diseases pathogenesis. |
| format | Article |
| id | doaj-art-9d2364934d96439d9868420163939e31 |
| institution | DOAJ |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-9d2364934d96439d9868420163939e312025-08-20T03:01:15Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352024-05-01232586210.15690/vsp.v23i2.27222164Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Diseases: Literature ReviewAnatoly I. Khavkin0Andrew V. Nalyotov1Dmitry I. Masyuta2Ravil F. Makhmutov3Research and Clinical Institute for Children; Belgorod State UniversityDonetsk State Medical University named after M. GorkyDonetsk State Medical University named after M. GorkyDonetsk State Medical University named after M. GorkyThe pathogenesis of inflammatory bowel diseases still remains unclear nowadays. Genetic disposition, impaired immune regulation, disturbance in intestinal microbiota composition, exposure to environmental factors are associated with the development of inflammation in intestinal mucosa and increased epithelial penetrance that define disease's development and progression. There is a theory in scientific literature that vitamin D deficiency (among other environmental factors) increases the risk of inflammatory bowel disease. However, the role of vitamin D in the development of gastrointestinal tract diseases remains poorly studied. This article presents current data on the vitamin D effect on the intestinal mucosa barrier function, on the immune system and on the intestinal microbiota in the context of inflammatory bowel diseases pathogenesis.https://vsp.spr-journal.ru/jour/article/view/3448inflammatory bowel diseasespathogenesisvitamin dintestinal microbiota |
| spellingShingle | Anatoly I. Khavkin Andrew V. Nalyotov Dmitry I. Masyuta Ravil F. Makhmutov Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Diseases: Literature Review Вопросы современной педиатрии inflammatory bowel diseases pathogenesis vitamin d intestinal microbiota |
| title | Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Diseases: Literature Review |
| title_full | Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Diseases: Literature Review |
| title_fullStr | Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Diseases: Literature Review |
| title_full_unstemmed | Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Diseases: Literature Review |
| title_short | Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Diseases: Literature Review |
| title_sort | role of vitamin d in the pathogenesis of inflammatory bowel diseases literature review |
| topic | inflammatory bowel diseases pathogenesis vitamin d intestinal microbiota |
| url | https://vsp.spr-journal.ru/jour/article/view/3448 |
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