Hepatoprotective Effects of Extracts and Polysaccharides from Seaweed
Antioxidants of natural origin are considered as possible agents for prevention and treatment of liver diseases. Marine algae and in particular their extracts and obtained from them sulfated polysaccharides are significant sources of natural antioxidants. The recent data on the effect of the extract...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/540 |
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| author | N. N. Besednova T. S. Zaporozhets T. A. Kuznetsova S. P. Kryzhanovskii N. N. Kovalev T. N. Zvyagintseva |
| author_facet | N. N. Besednova T. S. Zaporozhets T. A. Kuznetsova S. P. Kryzhanovskii N. N. Kovalev T. N. Zvyagintseva |
| author_sort | N. N. Besednova |
| collection | DOAJ |
| description | Antioxidants of natural origin are considered as possible agents for prevention and treatment of liver diseases. Marine algae and in particular their extracts and obtained from them sulfated polysaccharides are significant sources of natural antioxidants. The recent data on the effect of the extracts and sulfated polysaccharides of seaweed on the functional activity of the liver with injuries induced by CCl4, some drugs (paracetamol, diclofenac), N-nitrosocompounds, aflatoxin are presented in the review.Particular attention is paid to the effect of sulfated polysaccharides and in particular fucoidans on the functional activity of the liver in patients with chronic viral hepatitis C. Fucoidan is highly safe and active not only as an antioxidant but also as an inhibitor of HCV replication, has antiinflammatory and immunomodulating effects. The data of the review allow to conclude that seaweed extracts and sulfated polysaccharides may be a basis for development of new generation drugs in the future for the treatment and prevention of liver diseases. |
| format | Article |
| id | doaj-art-9d2207c1c2aa4306929c93d62729ed96 |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-9d2207c1c2aa4306929c93d62729ed962025-08-20T03:59:08ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01593-43037539Hepatoprotective Effects of Extracts and Polysaccharides from SeaweedN. N. Besednova0T. S. Zaporozhets1T. A. Kuznetsova2S. P. Kryzhanovskii3N. N. Kovalev4T. N. Zvyagintseva5G.P. Somov Research Institute of Epidemiology and Microbiology, Siberian Branch of Russian Academy of Medical SciencesG.P. Somov Research Institute of Epidemiology and Microbiology, Siberian Branch of Russian Academy of Medical SciencesG.P. Somov Research Institute of Epidemiology and Microbiology, Siberian Branch of Russian Academy of Medical SciencesVladivostok Medical Association, Far East Branch of Russian Academy of Sciences, VladivostokG.P. Somov Research Institute of Epidemiology and Microbiology, Siberian Branch of Russian Academy of Medical SciencesG.В. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of Russian Academy of Science, VladivostokAntioxidants of natural origin are considered as possible agents for prevention and treatment of liver diseases. Marine algae and in particular their extracts and obtained from them sulfated polysaccharides are significant sources of natural antioxidants. The recent data on the effect of the extracts and sulfated polysaccharides of seaweed on the functional activity of the liver with injuries induced by CCl4, some drugs (paracetamol, diclofenac), N-nitrosocompounds, aflatoxin are presented in the review.Particular attention is paid to the effect of sulfated polysaccharides and in particular fucoidans on the functional activity of the liver in patients with chronic viral hepatitis C. Fucoidan is highly safe and active not only as an antioxidant but also as an inhibitor of HCV replication, has antiinflammatory and immunomodulating effects. The data of the review allow to conclude that seaweed extracts and sulfated polysaccharides may be a basis for development of new generation drugs in the future for the treatment and prevention of liver diseases.https://www.antibiotics-chemotherapy.ru/jour/article/view/540hepatoprotectorsantioxidantspolysaccharides from seaweedfucoidans |
| spellingShingle | N. N. Besednova T. S. Zaporozhets T. A. Kuznetsova S. P. Kryzhanovskii N. N. Kovalev T. N. Zvyagintseva Hepatoprotective Effects of Extracts and Polysaccharides from Seaweed Антибиотики и Химиотерапия hepatoprotectors antioxidants polysaccharides from seaweed fucoidans |
| title | Hepatoprotective Effects of Extracts and Polysaccharides from Seaweed |
| title_full | Hepatoprotective Effects of Extracts and Polysaccharides from Seaweed |
| title_fullStr | Hepatoprotective Effects of Extracts and Polysaccharides from Seaweed |
| title_full_unstemmed | Hepatoprotective Effects of Extracts and Polysaccharides from Seaweed |
| title_short | Hepatoprotective Effects of Extracts and Polysaccharides from Seaweed |
| title_sort | hepatoprotective effects of extracts and polysaccharides from seaweed |
| topic | hepatoprotectors antioxidants polysaccharides from seaweed fucoidans |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/540 |
| work_keys_str_mv | AT nnbesednova hepatoprotectiveeffectsofextractsandpolysaccharidesfromseaweed AT tszaporozhets hepatoprotectiveeffectsofextractsandpolysaccharidesfromseaweed AT takuznetsova hepatoprotectiveeffectsofextractsandpolysaccharidesfromseaweed AT spkryzhanovskii hepatoprotectiveeffectsofextractsandpolysaccharidesfromseaweed AT nnkovalev hepatoprotectiveeffectsofextractsandpolysaccharidesfromseaweed AT tnzvyagintseva hepatoprotectiveeffectsofextractsandpolysaccharidesfromseaweed |