Of mice, cattle, and humans: the immunology and treatment of river blindness.
River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the parasite can only develop fully in humans and some pri...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2008-04-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0000217&type=printable |
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| _version_ | 1850243726988804096 |
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| author | Judith E Allen Ohene Adjei Odile Bain Achim Hoerauf Wolfgang H Hoffmann Benjamin L Makepeace Hartwig Schulz-Key Vincent N Tanya Alexander J Trees Samuel Wanji David W Taylor |
| author_facet | Judith E Allen Ohene Adjei Odile Bain Achim Hoerauf Wolfgang H Hoffmann Benjamin L Makepeace Hartwig Schulz-Key Vincent N Tanya Alexander J Trees Samuel Wanji David W Taylor |
| author_sort | Judith E Allen |
| collection | DOAJ |
| description | River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the parasite can only develop fully in humans and some primates. This review highlights the development of two animal model systems that have allowed significant advances in recent years and hold promise for the future. Experimental findings with Litomosoides sigmodontis in mice and Onchocerca ochengi in cattle are placed in the context of how these models can advance our ability to control the human disease. |
| format | Article |
| id | doaj-art-9d1f33605a1b4e62a09a3c957b063a9e |
| institution | OA Journals |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2008-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-9d1f33605a1b4e62a09a3c957b063a9e2025-08-20T01:59:56ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352008-04-0124e21710.1371/journal.pntd.0000217Of mice, cattle, and humans: the immunology and treatment of river blindness.Judith E AllenOhene AdjeiOdile BainAchim HoeraufWolfgang H HoffmannBenjamin L MakepeaceHartwig Schulz-KeyVincent N TanyaAlexander J TreesSamuel WanjiDavid W TaylorRiver blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the parasite can only develop fully in humans and some primates. This review highlights the development of two animal model systems that have allowed significant advances in recent years and hold promise for the future. Experimental findings with Litomosoides sigmodontis in mice and Onchocerca ochengi in cattle are placed in the context of how these models can advance our ability to control the human disease.https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0000217&type=printable |
| spellingShingle | Judith E Allen Ohene Adjei Odile Bain Achim Hoerauf Wolfgang H Hoffmann Benjamin L Makepeace Hartwig Schulz-Key Vincent N Tanya Alexander J Trees Samuel Wanji David W Taylor Of mice, cattle, and humans: the immunology and treatment of river blindness. PLoS Neglected Tropical Diseases |
| title | Of mice, cattle, and humans: the immunology and treatment of river blindness. |
| title_full | Of mice, cattle, and humans: the immunology and treatment of river blindness. |
| title_fullStr | Of mice, cattle, and humans: the immunology and treatment of river blindness. |
| title_full_unstemmed | Of mice, cattle, and humans: the immunology and treatment of river blindness. |
| title_short | Of mice, cattle, and humans: the immunology and treatment of river blindness. |
| title_sort | of mice cattle and humans the immunology and treatment of river blindness |
| url | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0000217&type=printable |
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