SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells.

SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells.

SAMHD1 restricts the replication of HIV-1 and other retroviruses in human myeloid and resting CD4(+) T cells and that is counteracted in SIV and HIV-2 by the Vpx accessory protein. The protein is a phosphohydrolase that lowers the concentration of deoxynucleoside triphosphates (dNTP), blocking rever...

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Bibliographic Details
Main Authors: Ruonan Zhang, Nicolin Bloch, Laura A Nguyen, Baek Kim, Nathaniel R Landau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089558&type=printable
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