Will adaptive deep brain stimulation for Parkinson’s disease become a real option soon? A Delphi consensus study
Abstract While conventional deep brain stimulation (cDBS) treatment delivers continuous electrical stimuli, new adaptive DBS (aDBS) technology provides dynamic symptom-related stimulation. Research data are promising, and devices are already available, but are we ready for it? We asked leading DBS e...
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Nature Portfolio
2025-05-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-00974-5 |
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| author | Matteo Guidetti Tommaso Bocci Marta De Pedro Del Álamo Guenther Deuschl Alfonso Fasano Raul Martinez-Fernandez Carmen Gasca-Salas Clement Hamani Joachim K. Krauss Andrea A. Kühn Patricia Limousin Simon Little Andres M. Lozano Natale V. Maiorana Sara Marceglia Michael S. Okun Serena Oliveri Jill L. Ostrem Emma Scelzo Alfons Schnitzler Philip A. Starr Yasin Temel Lars Timmermann Gerd Tinkhauser Veerle Visser-Vandewalle Jens Volkmann Alberto Priori |
| author_facet | Matteo Guidetti Tommaso Bocci Marta De Pedro Del Álamo Guenther Deuschl Alfonso Fasano Raul Martinez-Fernandez Carmen Gasca-Salas Clement Hamani Joachim K. Krauss Andrea A. Kühn Patricia Limousin Simon Little Andres M. Lozano Natale V. Maiorana Sara Marceglia Michael S. Okun Serena Oliveri Jill L. Ostrem Emma Scelzo Alfons Schnitzler Philip A. Starr Yasin Temel Lars Timmermann Gerd Tinkhauser Veerle Visser-Vandewalle Jens Volkmann Alberto Priori |
| author_sort | Matteo Guidetti |
| collection | DOAJ |
| description | Abstract While conventional deep brain stimulation (cDBS) treatment delivers continuous electrical stimuli, new adaptive DBS (aDBS) technology provides dynamic symptom-related stimulation. Research data are promising, and devices are already available, but are we ready for it? We asked leading DBS experts worldwide (n = 21) to discuss a research agenda for aDBS research in the near future to allow full adoption. A 5-point Likert scale questionnaire, along with a Delphi method, was employed. In the next 10 years, aDBS will be clinical routine, but research is needed to define which patients would benefit more from the treatment; second, implantation and programming procedures should be simplified to allow actual generalized adoption; third, new adaptive algorithms, and the integration of aDBS paradigm with new technologies, will improve control of more complex symptoms. Since the next years will be crucial for aDBS implementation, the research should focus on improving precision and making programming procedures more accessible. |
| format | Article |
| id | doaj-art-9d17fc38ffb14d4c9269ee8b5f328a11 |
| institution | DOAJ |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-9d17fc38ffb14d4c9269ee8b5f328a112025-08-20T03:09:34ZengNature Portfolionpj Parkinson's Disease2373-80572025-05-0111111110.1038/s41531-025-00974-5Will adaptive deep brain stimulation for Parkinson’s disease become a real option soon? A Delphi consensus studyMatteo Guidetti0Tommaso Bocci1Marta De Pedro Del Álamo2Guenther Deuschl3Alfonso Fasano4Raul Martinez-Fernandez5Carmen Gasca-Salas6Clement Hamani7Joachim K. Krauss8Andrea A. Kühn9Patricia Limousin10Simon Little11Andres M. Lozano12Natale V. Maiorana13Sara Marceglia14Michael S. Okun15Serena Oliveri16Jill L. Ostrem17Emma Scelzo18Alfons Schnitzler19Philip A. Starr20Yasin Temel21Lars Timmermann22Gerd Tinkhauser23Veerle Visser-Vandewalle24Jens Volkmann25Alberto Priori26Department of Health Sciences, “Aldo Ravelli” Center for Neurotechnology and Experimental Brain Therapeutics, University of MilanDepartment of Health Sciences, “Aldo Ravelli” Center for Neurotechnology and Experimental Brain Therapeutics, University of MilanHM CINAC, Hospital Universitario HM Puerta del Sur, HM HospitalesDepartment of Neurology, University Hospital Schleswig-Holstein, Campus Kiel and Christian Albrechts-University of Kiel Kiel GermanyKrembil Research Institute, University Health NetworkHM CINAC, Hospital Universitario HM Puerta del Sur, HM HospitalesHM CINAC, Hospital Universitario HM Puerta del Sur, HM HospitalesSunnybrook Health Sciences CentreDepartment of Neurosurgery, Hannover Medical SchoolDepartment of Neurology, Charité-Universitätsmedizin BerlinDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology and the National Hospital for Neurology and NeurosurgeryMovement Disorders and Neuromodulation Centre, University of California San FranciscoKrembil Research Institute, University Health NetworkDepartment of Health Sciences, “Aldo Ravelli” Center for Neurotechnology and Experimental Brain Therapeutics, University of MilanDepartment of Health Sciences, “Aldo Ravelli” Center for Neurotechnology and Experimental Brain Therapeutics, University of MilanNorman Fixel Institute for Neurological Diseases, University of FloridaDepartment of Health Sciences, “Aldo Ravelli” Center for Neurotechnology and Experimental Brain Therapeutics, University of MilanMovement Disorders and Neuromodulation Centre, University of California San FranciscoClinical Neurology Unit, Department of Health Sciences, “Azienda Socio-Sanitaria Territoriale Santi Paolo e Carlo”, University of MilanInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine UniversityUCSF Department of Neurological Surgery, University of California San FranciscoDepartment of Neurosurgery, Maastricht University Medical CenterDepartment of Neurology, University Hospital of MarburgDepartment of Neurology, Bern University Hospital and University of BernDepartment of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of CologneDepartment of Neurology, University Hospital WürzburgDepartment of Health Sciences, “Aldo Ravelli” Center for Neurotechnology and Experimental Brain Therapeutics, University of MilanAbstract While conventional deep brain stimulation (cDBS) treatment delivers continuous electrical stimuli, new adaptive DBS (aDBS) technology provides dynamic symptom-related stimulation. Research data are promising, and devices are already available, but are we ready for it? We asked leading DBS experts worldwide (n = 21) to discuss a research agenda for aDBS research in the near future to allow full adoption. A 5-point Likert scale questionnaire, along with a Delphi method, was employed. In the next 10 years, aDBS will be clinical routine, but research is needed to define which patients would benefit more from the treatment; second, implantation and programming procedures should be simplified to allow actual generalized adoption; third, new adaptive algorithms, and the integration of aDBS paradigm with new technologies, will improve control of more complex symptoms. Since the next years will be crucial for aDBS implementation, the research should focus on improving precision and making programming procedures more accessible.https://doi.org/10.1038/s41531-025-00974-5 |
| spellingShingle | Matteo Guidetti Tommaso Bocci Marta De Pedro Del Álamo Guenther Deuschl Alfonso Fasano Raul Martinez-Fernandez Carmen Gasca-Salas Clement Hamani Joachim K. Krauss Andrea A. Kühn Patricia Limousin Simon Little Andres M. Lozano Natale V. Maiorana Sara Marceglia Michael S. Okun Serena Oliveri Jill L. Ostrem Emma Scelzo Alfons Schnitzler Philip A. Starr Yasin Temel Lars Timmermann Gerd Tinkhauser Veerle Visser-Vandewalle Jens Volkmann Alberto Priori Will adaptive deep brain stimulation for Parkinson’s disease become a real option soon? A Delphi consensus study npj Parkinson's Disease |
| title | Will adaptive deep brain stimulation for Parkinson’s disease become a real option soon? A Delphi consensus study |
| title_full | Will adaptive deep brain stimulation for Parkinson’s disease become a real option soon? A Delphi consensus study |
| title_fullStr | Will adaptive deep brain stimulation for Parkinson’s disease become a real option soon? A Delphi consensus study |
| title_full_unstemmed | Will adaptive deep brain stimulation for Parkinson’s disease become a real option soon? A Delphi consensus study |
| title_short | Will adaptive deep brain stimulation for Parkinson’s disease become a real option soon? A Delphi consensus study |
| title_sort | will adaptive deep brain stimulation for parkinson s disease become a real option soon a delphi consensus study |
| url | https://doi.org/10.1038/s41531-025-00974-5 |
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