The Correlation between Endoscopic Reflux Esophagitis and Combined Multichannel Intraluminal Impedance-pH Monitoring in Children
Gastroesophageal reflux (GER) is the retrograde flow of gastric contents into the esophagus and may induce a variety of complications. Endoscopically visible breaks in the distal esophageal mucosa are the most reliable evidence of reflux esophagitis. Combined multichannel intraluminal impedance and...
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Elsevier
2016-10-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957215001837 |
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| author | Yu-Wen Liu Jia-Feng Wu Huey-Ling Chen Hong-Yuan Hsu Mei-Hwei Chang Wei-Chung Hsu Ping-Huei Tseng Hsiu-Po Wang Yen-Hsuan Ni |
| author_facet | Yu-Wen Liu Jia-Feng Wu Huey-Ling Chen Hong-Yuan Hsu Mei-Hwei Chang Wei-Chung Hsu Ping-Huei Tseng Hsiu-Po Wang Yen-Hsuan Ni |
| author_sort | Yu-Wen Liu |
| collection | DOAJ |
| description | Gastroesophageal reflux (GER) is the retrograde flow of gastric contents into the esophagus and may induce a variety of complications. Endoscopically visible breaks in the distal esophageal mucosa are the most reliable evidence of reflux esophagitis. Combined multichannel intraluminal impedance and pH-metry (MII-pH) is a technique that enables monitoring of GER independent of its acidity. The aim of this study is to investigate the GER patterns in children with the aid of MII-pH monitoring and determine the correlation between endoscopically proven reflux esophagitis and reflux types by MII-pH monitoring.
Methods: One hundred and twenty children were enrolled from January 2010 to October 2011 for MII-pH monitoring. We studied the GER patterns by means of pH (acid and nonacid reflux) and composition (liquid, mixed, and gas reflux) by the esophageal MII-pH signals. Meanwhile, 34 (28.3%) patients received esophagogastroduodenoscopy examination at the same time. The severity of reflux esophagitis was graded with Los Angeles classification.
Results: MII-pH monitoring significantly increased the detection of numbers of reflux compared with traditional 24-hour pH monitoring (p < 0.001). The significant cutoff value of MII-pH parameters including DeMeester score ≥ 21, duration of longest acid reflux ≥ 17 minutes, and occurrence of acid reflux for more than 5 minutes showed good correlation in the prediction of the presence of endoscopic reflux esophagitis. The odds ratios of the above mentioned parameters were 12.6, 8.94, and 7.5, respectively (p = 0.02, p = 0.01, and p = 0.01). Furthermore, ≥ 3 episodes per day of acid reflux for more than 5 minutes can predict the occurrence of severe reflux esophagitis (odds ratio 12.78, p = 0.009).
Conclusion: MII-pH monitoring not only raised the diagnostic yield in identifying GER, but it also showed significant correlation with the presence of endoscopically proven reflux esophagitis in children. |
| format | Article |
| id | doaj-art-9d15b3015bde4f0eaab3253f267fed82 |
| institution | DOAJ |
| issn | 1875-9572 |
| language | English |
| publishDate | 2016-10-01 |
| publisher | Elsevier |
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| series | Pediatrics and Neonatology |
| spelling | doaj-art-9d15b3015bde4f0eaab3253f267fed822025-08-20T03:19:46ZengElsevierPediatrics and Neonatology1875-95722016-10-0157538538910.1016/j.pedneo.2015.09.008The Correlation between Endoscopic Reflux Esophagitis and Combined Multichannel Intraluminal Impedance-pH Monitoring in ChildrenYu-Wen Liu0Jia-Feng Wu1Huey-Ling Chen2Hong-Yuan Hsu3Mei-Hwei Chang4Wei-Chung Hsu5Ping-Huei Tseng6Hsiu-Po Wang7Yen-Hsuan Ni8Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, TaiwanDepartment of Otolaryngology, National Taiwan University Hospital, National Taiwan University, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, TaiwanGastroesophageal reflux (GER) is the retrograde flow of gastric contents into the esophagus and may induce a variety of complications. Endoscopically visible breaks in the distal esophageal mucosa are the most reliable evidence of reflux esophagitis. Combined multichannel intraluminal impedance and pH-metry (MII-pH) is a technique that enables monitoring of GER independent of its acidity. The aim of this study is to investigate the GER patterns in children with the aid of MII-pH monitoring and determine the correlation between endoscopically proven reflux esophagitis and reflux types by MII-pH monitoring. Methods: One hundred and twenty children were enrolled from January 2010 to October 2011 for MII-pH monitoring. We studied the GER patterns by means of pH (acid and nonacid reflux) and composition (liquid, mixed, and gas reflux) by the esophageal MII-pH signals. Meanwhile, 34 (28.3%) patients received esophagogastroduodenoscopy examination at the same time. The severity of reflux esophagitis was graded with Los Angeles classification. Results: MII-pH monitoring significantly increased the detection of numbers of reflux compared with traditional 24-hour pH monitoring (p < 0.001). The significant cutoff value of MII-pH parameters including DeMeester score ≥ 21, duration of longest acid reflux ≥ 17 minutes, and occurrence of acid reflux for more than 5 minutes showed good correlation in the prediction of the presence of endoscopic reflux esophagitis. The odds ratios of the above mentioned parameters were 12.6, 8.94, and 7.5, respectively (p = 0.02, p = 0.01, and p = 0.01). Furthermore, ≥ 3 episodes per day of acid reflux for more than 5 minutes can predict the occurrence of severe reflux esophagitis (odds ratio 12.78, p = 0.009). Conclusion: MII-pH monitoring not only raised the diagnostic yield in identifying GER, but it also showed significant correlation with the presence of endoscopically proven reflux esophagitis in children.http://www.sciencedirect.com/science/article/pii/S1875957215001837esophageal impedancegastroesophageal refluxreflux esophagitis |
| spellingShingle | Yu-Wen Liu Jia-Feng Wu Huey-Ling Chen Hong-Yuan Hsu Mei-Hwei Chang Wei-Chung Hsu Ping-Huei Tseng Hsiu-Po Wang Yen-Hsuan Ni The Correlation between Endoscopic Reflux Esophagitis and Combined Multichannel Intraluminal Impedance-pH Monitoring in Children Pediatrics and Neonatology esophageal impedance gastroesophageal reflux reflux esophagitis |
| title | The Correlation between Endoscopic Reflux Esophagitis and Combined Multichannel Intraluminal Impedance-pH Monitoring in Children |
| title_full | The Correlation between Endoscopic Reflux Esophagitis and Combined Multichannel Intraluminal Impedance-pH Monitoring in Children |
| title_fullStr | The Correlation between Endoscopic Reflux Esophagitis and Combined Multichannel Intraluminal Impedance-pH Monitoring in Children |
| title_full_unstemmed | The Correlation between Endoscopic Reflux Esophagitis and Combined Multichannel Intraluminal Impedance-pH Monitoring in Children |
| title_short | The Correlation between Endoscopic Reflux Esophagitis and Combined Multichannel Intraluminal Impedance-pH Monitoring in Children |
| title_sort | correlation between endoscopic reflux esophagitis and combined multichannel intraluminal impedance ph monitoring in children |
| topic | esophageal impedance gastroesophageal reflux reflux esophagitis |
| url | http://www.sciencedirect.com/science/article/pii/S1875957215001837 |
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