EGR1 regulates oxidative stress and aldosterone production in adrenal cells and aldosterone-producing adenomas

EGR1 regulates oxidative stress and aldosterone production in adrenal cells and aldosterone-producing adenomas

Aldosterone-producing adenomas (APAs) are a major cause of primary aldosteronism, a common form of endocrine hypertension. Here, we demonstrate that Early Growth Response 1 (EGR1) plays a dual role in adrenal cell biology, regulating both oxidative stress and aldosterone production. Using RNA sequen...

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Bibliographic Details
Main Authors: Yingxian Pang, Siyuan Gong, Martina Tetti, Zhuolun Sun, Sanas Mir-Bashiri, Martin Bidlingmaier, Thomas Knösel, Eckhard Wolf, Martin Reincke, Elisabeth Kemter, Tracy Ann Williams
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Redox Biology
Subjects:
Adrenal gland
Aldosterone-producing adenomas
Early growth response 1
Oxidative stress
CYP11B2
Hyperaldosteronism
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725000114
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