Multi-metal mixture exposure and cognitive function in urban older adults: The mediation effects of thyroid hormones
The existing studies on the association between multi-metal mixture exposure and cognitive function in the older adults are limited and controversial, with no studies considering the mediating effect of thyroid hormones on the connection between them. This study of 441 urban older adults assessed 21...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325001046 |
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| author | Zhuoqi Zhu Juanhua Li Yang Peng Ning Qin Jiemei Li Ying Wei Biwen Wang Yunfei Liao Huaicai Zeng Lu Cheng Han Li |
| author_facet | Zhuoqi Zhu Juanhua Li Yang Peng Ning Qin Jiemei Li Ying Wei Biwen Wang Yunfei Liao Huaicai Zeng Lu Cheng Han Li |
| author_sort | Zhuoqi Zhu |
| collection | DOAJ |
| description | The existing studies on the association between multi-metal mixture exposure and cognitive function in the older adults are limited and controversial, with no studies considering the mediating effect of thyroid hormones on the connection between them. This study of 441 urban older adults assessed 21 urinary metal levels and cognitive function using the Mini-Mental State Examination (MMSE). Urinary metal levels were measured via inductively coupled plasma mass spectrometry (ICP-MS), and thyroid hormones levels were obtained from medical records. Mediation analysis evaluated the role of thyroid hormones in the link between metals exposure and cognitive function. The General Linear Model (GLM) showed negative correlations between MMSE scores and titanium (Ti), copper (Cu), rubidium (Rb), and molybdenum (Mo), and positive correlations with selenium (Se) and barium (Ba). Nonlinear inverse U-shaped associations between Mo, Rb, and MMSE scores were identified using Restricted Cubic Splines (RCS) and Bayesian Kernel Machine Regression (BKMR). Mediation analysis revealed that Free Thyroxine (FT4) mediated the relationship between Rb and MMSE scores by 29.10 % and between Zinc (Zn) and language performance by 35.00 %. Total thyroxine (TT4) mediated the link between Cu and orientation score by 24.69 %, and Thyroid Stimulating Hormone (TSH) mediated the association between Cu and attention score by 38.96 %. Ti, Se, Rb, Mo, Ba and Cu were significantly associated with cognitive impairment risk. Mixed exposure to Mo and Rb was linked to an increased risk of cognitive impairment. Additionally, levels of TSH, FT4 and TT4 were associated with cognitive function, mediating the effects of Rb, Zn and Cu on cognitive function. |
| format | Article |
| id | doaj-art-9d12e91513a0443f8b13f0d791688022 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-9d12e91513a0443f8b13f0d7916880222025-02-12T05:30:17ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117768Multi-metal mixture exposure and cognitive function in urban older adults: The mediation effects of thyroid hormonesZhuoqi Zhu0Juanhua Li1Yang Peng2Ning Qin3Jiemei Li4Ying Wei5Biwen Wang6Yunfei Liao7Huaicai Zeng8Lu Cheng9Han Li10Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China; Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning 530021, ChinaGuangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning 530021, China; Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning 530021, ChinaGuangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning 530021, China; Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning 530021, ChinaGuangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning 530021, China; Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning 530021, ChinaGuangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning 530021, China; Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning 530021, ChinaGuangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning 530021, China; Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning 530021, ChinaGuangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning 530021, China; Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning 530021, ChinaGuangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning 530021, China; Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning 530021, ChinaGuangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, Guilin Medical University, ChinaDepartment of Psychiatry, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518064, China; Corresponding author.Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning 530021, China; Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, Guilin Medical University, China; Corresponding author at: Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning 530021, China.The existing studies on the association between multi-metal mixture exposure and cognitive function in the older adults are limited and controversial, with no studies considering the mediating effect of thyroid hormones on the connection between them. This study of 441 urban older adults assessed 21 urinary metal levels and cognitive function using the Mini-Mental State Examination (MMSE). Urinary metal levels were measured via inductively coupled plasma mass spectrometry (ICP-MS), and thyroid hormones levels were obtained from medical records. Mediation analysis evaluated the role of thyroid hormones in the link between metals exposure and cognitive function. The General Linear Model (GLM) showed negative correlations between MMSE scores and titanium (Ti), copper (Cu), rubidium (Rb), and molybdenum (Mo), and positive correlations with selenium (Se) and barium (Ba). Nonlinear inverse U-shaped associations between Mo, Rb, and MMSE scores were identified using Restricted Cubic Splines (RCS) and Bayesian Kernel Machine Regression (BKMR). Mediation analysis revealed that Free Thyroxine (FT4) mediated the relationship between Rb and MMSE scores by 29.10 % and between Zinc (Zn) and language performance by 35.00 %. Total thyroxine (TT4) mediated the link between Cu and orientation score by 24.69 %, and Thyroid Stimulating Hormone (TSH) mediated the association between Cu and attention score by 38.96 %. Ti, Se, Rb, Mo, Ba and Cu were significantly associated with cognitive impairment risk. Mixed exposure to Mo and Rb was linked to an increased risk of cognitive impairment. Additionally, levels of TSH, FT4 and TT4 were associated with cognitive function, mediating the effects of Rb, Zn and Cu on cognitive function.http://www.sciencedirect.com/science/article/pii/S0147651325001046Multi-metalCognitive FunctionJoint effectThyroid hormoneEffect of mediation |
| spellingShingle | Zhuoqi Zhu Juanhua Li Yang Peng Ning Qin Jiemei Li Ying Wei Biwen Wang Yunfei Liao Huaicai Zeng Lu Cheng Han Li Multi-metal mixture exposure and cognitive function in urban older adults: The mediation effects of thyroid hormones Ecotoxicology and Environmental Safety Multi-metal Cognitive Function Joint effect Thyroid hormone Effect of mediation |
| title | Multi-metal mixture exposure and cognitive function in urban older adults: The mediation effects of thyroid hormones |
| title_full | Multi-metal mixture exposure and cognitive function in urban older adults: The mediation effects of thyroid hormones |
| title_fullStr | Multi-metal mixture exposure and cognitive function in urban older adults: The mediation effects of thyroid hormones |
| title_full_unstemmed | Multi-metal mixture exposure and cognitive function in urban older adults: The mediation effects of thyroid hormones |
| title_short | Multi-metal mixture exposure and cognitive function in urban older adults: The mediation effects of thyroid hormones |
| title_sort | multi metal mixture exposure and cognitive function in urban older adults the mediation effects of thyroid hormones |
| topic | Multi-metal Cognitive Function Joint effect Thyroid hormone Effect of mediation |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325001046 |
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