Circulating leptin and resistin levels in myocardial infarction patients with insulin resistance
Objective The study investigated the link between the homeostatic model assessment for insulin resistance (HOMA-IR) and myocardial infarction (MI) parameters, highlighting its role as a potential MI biomarker in Southern Saudi patients. Methods This cross-sectional study conducted from January to Ap...
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SAGE Publishing
2025-03-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605251325162 |
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| author | Ayed A. Dera |
| author_facet | Ayed A. Dera |
| author_sort | Ayed A. Dera |
| collection | DOAJ |
| description | Objective The study investigated the link between the homeostatic model assessment for insulin resistance (HOMA-IR) and myocardial infarction (MI) parameters, highlighting its role as a potential MI biomarker in Southern Saudi patients. Methods This cross-sectional study conducted from January to April 2021 at the Prince Faisal Bin Khalid Cardiac Center, Abha, Saudi Arabia, examined cardiovascular and diabetic biomarkers, including HOMA-IR, in MI patients and controls to assess insulin resistance (IR), risk, and diagnostic accuracy. Results MI patients showed significantly elevated HOMA-IR, leptin, resistin, body mass index (BMI), and glucose-complexed hemoglobin (HbA1c) levels compared with controls in both genders ( p < 0.0001). HbA1c was strongly associated with HOMA-IR, whereas age, BMI, leptin, and resistin showed weak correlations. Elevated HOMA-IR increased MI risk and demonstrated high diagnostic accuracy. Conclusions Elevated HOMA-IR was identified as an early indicator of the onset of MI, whereas serum leptin and resistin levels exhibited a positive association with IR in patients with MI. Moreover, serum leptin, resistin, and elevated HOMA-IR may independently contribute to the risk of MI. |
| format | Article |
| id | doaj-art-9d0c2ca28ca44d1c92681efd58aa28e9 |
| institution | OA Journals |
| issn | 1473-2300 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj-art-9d0c2ca28ca44d1c92681efd58aa28e92025-08-20T02:27:29ZengSAGE PublishingJournal of International Medical Research1473-23002025-03-015310.1177/03000605251325162Circulating leptin and resistin levels in myocardial infarction patients with insulin resistanceAyed A. DeraObjective The study investigated the link between the homeostatic model assessment for insulin resistance (HOMA-IR) and myocardial infarction (MI) parameters, highlighting its role as a potential MI biomarker in Southern Saudi patients. Methods This cross-sectional study conducted from January to April 2021 at the Prince Faisal Bin Khalid Cardiac Center, Abha, Saudi Arabia, examined cardiovascular and diabetic biomarkers, including HOMA-IR, in MI patients and controls to assess insulin resistance (IR), risk, and diagnostic accuracy. Results MI patients showed significantly elevated HOMA-IR, leptin, resistin, body mass index (BMI), and glucose-complexed hemoglobin (HbA1c) levels compared with controls in both genders ( p < 0.0001). HbA1c was strongly associated with HOMA-IR, whereas age, BMI, leptin, and resistin showed weak correlations. Elevated HOMA-IR increased MI risk and demonstrated high diagnostic accuracy. Conclusions Elevated HOMA-IR was identified as an early indicator of the onset of MI, whereas serum leptin and resistin levels exhibited a positive association with IR in patients with MI. Moreover, serum leptin, resistin, and elevated HOMA-IR may independently contribute to the risk of MI.https://doi.org/10.1177/03000605251325162 |
| spellingShingle | Ayed A. Dera Circulating leptin and resistin levels in myocardial infarction patients with insulin resistance Journal of International Medical Research |
| title | Circulating leptin and resistin levels in myocardial infarction patients with insulin resistance |
| title_full | Circulating leptin and resistin levels in myocardial infarction patients with insulin resistance |
| title_fullStr | Circulating leptin and resistin levels in myocardial infarction patients with insulin resistance |
| title_full_unstemmed | Circulating leptin and resistin levels in myocardial infarction patients with insulin resistance |
| title_short | Circulating leptin and resistin levels in myocardial infarction patients with insulin resistance |
| title_sort | circulating leptin and resistin levels in myocardial infarction patients with insulin resistance |
| url | https://doi.org/10.1177/03000605251325162 |
| work_keys_str_mv | AT ayedadera circulatingleptinandresistinlevelsinmyocardialinfarctionpatientswithinsulinresistance |