Irisin: Emerging Therapeutic Targets for Cognitive Impairment-Related Diseases
Abstract Introduction Irisin is a glycosylated polypeptide hormone derived from muscles that plays a crucial role in learning and memory by promoting the growth of hippocampal neurons, thereby influencing cognitive function. Objective Despite increasing evidence, a comprehensive understanding of...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2025-01-01
|
| Series: | Expert Reviews in Molecular Medicine |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S1462399425100148/type/journal_article |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849233058555756544 |
|---|---|
| author | Mei Ma Guangchan Jing Yue Tian Ruiying Yin Mengren Zhang |
| author_facet | Mei Ma Guangchan Jing Yue Tian Ruiying Yin Mengren Zhang |
| author_sort | Mei Ma |
| collection | DOAJ |
| description |
Abstract
Introduction
Irisin is a glycosylated polypeptide hormone derived from muscles that plays a crucial role in learning and memory by promoting the growth of hippocampal neurons, thereby influencing cognitive function.
Objective
Despite increasing evidence, a comprehensive understanding of the exact role of irisin remains elusive, necessitating further research to unravel the complex mechanisms through which irisin influences cognitive function and to explore therapeutic approaches targeting irisin.
Method
A literature review was performed by searching PubMed for articles published between 2012 and 2024, using the keywords ‘fibronectin type III domain-containing 5 (FNDC5)’, ‘irisin’, ‘cognitive impairment’, ‘Alzheimer’s disease’, ‘Age-related cognitive dysfunction’ and ‘Diabetes-associated cognitive dysfunction’, combined with Boolean operators (AND/OR).
Results
This review highlighted the potential impact of irisin on cognitive function in the context of ageing, diabetes and Alzheimer’s disease. The anti-cognitive impairment effects of irisin are associated with the regulation of energy metabolism, insulin resistance, inflammation, oxidative stress, amyloid-beta deposition, synaptogenesis and plasticity. The signalling pathways through which irisin improves cognitive impairment are complex and highly regulated processes, involving multiple signalling pathways such as the adenosine monophosphate-activated protein kinase (AMPK) signalling pathway, mitogen-activated protein kinase (MAPK) signalling pathway, nuclear factor-κB (NF-κB) signalling pathway, ERK-STAT3 signalling pathway, cAMP/PKA/CREB signalling pathway and Nrf2/HO-1 signalling pathway.
Conclusion
This review delves into the positive effects of irisin on cognitive impairment, examines the signalling pathways related to fibronectin type III domain-containing 5 (FNDC5)/irisin and provides future perspectives for research on the anti-cognitive impairment effects of irisin.
|
| format | Article |
| id | doaj-art-9d0bdcdb26de42989ed4e3a3f44bb0b5 |
| institution | Kabale University |
| issn | 1462-3994 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Expert Reviews in Molecular Medicine |
| spelling | doaj-art-9d0bdcdb26de42989ed4e3a3f44bb0b52025-08-20T12:57:29ZengCambridge University PressExpert Reviews in Molecular Medicine1462-39942025-01-012710.1017/erm.2025.10014Irisin: Emerging Therapeutic Targets for Cognitive Impairment-Related DiseasesMei Ma0Guangchan Jing1Yue Tian2Ruiying Yin3Mengren Zhang4https://orcid.org/0009-0006-5174-1994Department of Traditional Chinese Medicine, https://ror.org/04jztag35Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Traditional Chinese Medicine, https://ror.org/04jztag35Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Traditional Chinese Medicine, https://ror.org/04jztag35Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Traditional Chinese Medicine, https://ror.org/04jztag35Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Traditional Chinese Medicine, https://ror.org/04jztag35Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Abstract Introduction Irisin is a glycosylated polypeptide hormone derived from muscles that plays a crucial role in learning and memory by promoting the growth of hippocampal neurons, thereby influencing cognitive function. Objective Despite increasing evidence, a comprehensive understanding of the exact role of irisin remains elusive, necessitating further research to unravel the complex mechanisms through which irisin influences cognitive function and to explore therapeutic approaches targeting irisin. Method A literature review was performed by searching PubMed for articles published between 2012 and 2024, using the keywords ‘fibronectin type III domain-containing 5 (FNDC5)’, ‘irisin’, ‘cognitive impairment’, ‘Alzheimer’s disease’, ‘Age-related cognitive dysfunction’ and ‘Diabetes-associated cognitive dysfunction’, combined with Boolean operators (AND/OR). Results This review highlighted the potential impact of irisin on cognitive function in the context of ageing, diabetes and Alzheimer’s disease. The anti-cognitive impairment effects of irisin are associated with the regulation of energy metabolism, insulin resistance, inflammation, oxidative stress, amyloid-beta deposition, synaptogenesis and plasticity. The signalling pathways through which irisin improves cognitive impairment are complex and highly regulated processes, involving multiple signalling pathways such as the adenosine monophosphate-activated protein kinase (AMPK) signalling pathway, mitogen-activated protein kinase (MAPK) signalling pathway, nuclear factor-κB (NF-κB) signalling pathway, ERK-STAT3 signalling pathway, cAMP/PKA/CREB signalling pathway and Nrf2/HO-1 signalling pathway. Conclusion This review delves into the positive effects of irisin on cognitive impairment, examines the signalling pathways related to fibronectin type III domain-containing 5 (FNDC5)/irisin and provides future perspectives for research on the anti-cognitive impairment effects of irisin. https://www.cambridge.org/core/product/identifier/S1462399425100148/type/journal_articleADcognitive impairmentDACDFNDC5irisin |
| spellingShingle | Mei Ma Guangchan Jing Yue Tian Ruiying Yin Mengren Zhang Irisin: Emerging Therapeutic Targets for Cognitive Impairment-Related Diseases Expert Reviews in Molecular Medicine AD cognitive impairment DACD FNDC5 irisin |
| title | Irisin: Emerging Therapeutic Targets for Cognitive Impairment-Related Diseases |
| title_full | Irisin: Emerging Therapeutic Targets for Cognitive Impairment-Related Diseases |
| title_fullStr | Irisin: Emerging Therapeutic Targets for Cognitive Impairment-Related Diseases |
| title_full_unstemmed | Irisin: Emerging Therapeutic Targets for Cognitive Impairment-Related Diseases |
| title_short | Irisin: Emerging Therapeutic Targets for Cognitive Impairment-Related Diseases |
| title_sort | irisin emerging therapeutic targets for cognitive impairment related diseases |
| topic | AD cognitive impairment DACD FNDC5 irisin |
| url | https://www.cambridge.org/core/product/identifier/S1462399425100148/type/journal_article |
| work_keys_str_mv | AT meima irisinemergingtherapeutictargetsforcognitiveimpairmentrelateddiseases AT guangchanjing irisinemergingtherapeutictargetsforcognitiveimpairmentrelateddiseases AT yuetian irisinemergingtherapeutictargetsforcognitiveimpairmentrelateddiseases AT ruiyingyin irisinemergingtherapeutictargetsforcognitiveimpairmentrelateddiseases AT mengrenzhang irisinemergingtherapeutictargetsforcognitiveimpairmentrelateddiseases |