Russian consensus on the use of incobotulinumtoxinA in children with cerebral palsy for the treatment of spasticity and sialorrhea
Botulinum therapy for cerebral palsy (CP) is considered not only as one of the effective approaches for the treatment of increased muscle tone and spasticity, but also as a method of excessive salivation correction. The article presents an overview of the results of Russian and foreign studies on th...
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2022-04-01
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| author | A. L. Kurenkov L. M. Kuzenkova B. I. Bursagova V. V. Chernikov O. V. Agranovich L. G. Khachatryan V. M. Kenis V. A. Zherebtsova M. N. Sarzhina N. D. Odinaeva A. R. Artemenko G. A. Popova E. A. Moroshek E. E. Tabe A. A. Nezhelskaya A. A. Maksimenko L. Ya. Akhadova M. V. Indereikin N. V. Duibanova L. V. Tikhonova A. V. Sapogovskiy Z. M. Gadzhialieva A. V. Grigorieva V. S. Perminov I. D. Fedonyuk L. M. Kolpakchi A. Yu. Kursakova N. A. Tsurina |
| author_facet | A. L. Kurenkov L. M. Kuzenkova B. I. Bursagova V. V. Chernikov O. V. Agranovich L. G. Khachatryan V. M. Kenis V. A. Zherebtsova M. N. Sarzhina N. D. Odinaeva A. R. Artemenko G. A. Popova E. A. Moroshek E. E. Tabe A. A. Nezhelskaya A. A. Maksimenko L. Ya. Akhadova M. V. Indereikin N. V. Duibanova L. V. Tikhonova A. V. Sapogovskiy Z. M. Gadzhialieva A. V. Grigorieva V. S. Perminov I. D. Fedonyuk L. M. Kolpakchi A. Yu. Kursakova N. A. Tsurina |
| author_sort | A. L. Kurenkov |
| collection | DOAJ |
| description | Botulinum therapy for cerebral palsy (CP) is considered not only as one of the effective approaches for the treatment of increased muscle tone and spasticity, but also as a method of excessive salivation correction. The article presents an overview of the results of Russian and foreign studies on the efficacy and safety of incobotulinumtoxinA for the treatment of spasticity of the lower and upper limbs, as well as sialorrhea in patients with CP. The article also provides a consensus opinion of Russian specialists working with patients with CP and using Xeomin (incobotulinumtoxinA) in their practice for the treatment of spasticity and sialorrhea. This consensus was based on the results of a Russian retrospective multicenter study on the use of incobotulinumtoxinA for the treatment of spasticity and sialorrhea in CP, data from recently published international clinical trials, and our own clinical experience. We present detailed practical recommendations on the calculation of the total dose of incobotulinumtoxinA per procedure for the treatment of spasticity in CP, on the calculation of incobotulinumtoxinA dose for the most common target muscles (lower and upper limbs) for spasticity treatment in CP, on incobotulinumtoxinA dilution and dose calculation for sialorrhea treatment in children, on incobotulinumtoxinA dilution and dose calculation for simultaneous treatment of spasticity and sialorrhea in CP. We justify incobotulinumtoxinA use, when simultaneous treatment of spasticity and sialorrhea is necessary, which allows reducing the intervals between repeated injection cycles. IncobotulinumtoxinA use in children with CP demonstrates a favorable safety profile, including long-term use. |
| format | Article |
| id | doaj-art-9d0b5cf529ef41c19d59bbf356c0c69c |
| institution | OA Journals |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| publishDate | 2022-04-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj-art-9d0b5cf529ef41c19d59bbf356c0c69c2025-08-20T02:16:17ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422022-04-0114211712510.14412/2074-2711-2022-2-117-1251260Russian consensus on the use of incobotulinumtoxinA in children with cerebral palsy for the treatment of spasticity and sialorrheaA. L. Kurenkov0L. M. Kuzenkova1B. I. Bursagova2V. V. Chernikov3O. V. Agranovich4L. G. Khachatryan5V. M. Kenis6V. A. Zherebtsova7M. N. Sarzhina8N. D. Odinaeva9A. R. Artemenko10G. A. Popova11E. A. Moroshek12E. E. Tabe13A. A. Nezhelskaya14A. A. Maksimenko15L. Ya. Akhadova16M. V. Indereikin17N. V. Duibanova18L. V. Tikhonova19A. V. Sapogovskiy20Z. M. Gadzhialieva21A. V. Grigorieva22V. S. Perminov23I. D. Fedonyuk24L. M. Kolpakchi25A. Yu. Kursakova26N. A. Tsurina27National Medical Research Center for Children's Health, Ministry of Health of Russia; Center of Interdisciplinary Dentistry and NeurologyNational Medical Research Center for Children's Health, Ministry of Health of RussiaNational Medical Research Center for Children's Health, Ministry of Health of RussiaNational Medical Research Center for Children's Health, Ministry of Health of RussiaRegional Children's Clinical Hospital, Stavropol; 4I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaI.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaG.I. Turner National Medical Research Center for Сhildren's Orthopedics and Trauma Surgery, Ministry of Health of RussiaChildren Psychoneurology CenterScientific and Practical Center of Pediatric Psychoneurology, Moscow Healthcare DepartmentResearch Clinical Institute of Childhood, Ministry of Health of the Moscow Region; Faculty of Advanced Medical Training, M.F. Vladimirsky Moscow Regional Research Clinical InstituteCenter of Interdisciplinary Dentistry and Neurology; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaCity Children's Clinical Emergency HospitalDr. Balbert ClinicNational Medical Research Center for Children's Health, Ministry of Health of RussiaNational Medical Research Center for Children's Health, Ministry of Health of RussiaChildren Psychoneurology CenterScientific and Practical Center of Pediatric Psychoneurology, Moscow Healthcare DepartmentChildren's Republican Clinical Hospital, Ministry of Health of the Republic of BuryatiaChildren's Republican Clinical Hospital, Ministry of Health of the Republic of BuryatiaCity Children's Clinical Emergency HospitalG.I. Turner National Medical Research Center for Сhildren's Orthopedics and Trauma Surgery, Ministry of Health of RussiaScientific and Practical Center of Pediatric Psychoneurology, Moscow Healthcare DepartmentYu.E. Veltishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaYu.E. Veltishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian Children's Clinical Hospital, N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian Children's Clinical Hospital, N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian Children's Clinical Hospital, N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaResearch Clinical Institute of Childhood, Ministry of Health of the Moscow RegionBotulinum therapy for cerebral palsy (CP) is considered not only as one of the effective approaches for the treatment of increased muscle tone and spasticity, but also as a method of excessive salivation correction. The article presents an overview of the results of Russian and foreign studies on the efficacy and safety of incobotulinumtoxinA for the treatment of spasticity of the lower and upper limbs, as well as sialorrhea in patients with CP. The article also provides a consensus opinion of Russian specialists working with patients with CP and using Xeomin (incobotulinumtoxinA) in their practice for the treatment of spasticity and sialorrhea. This consensus was based on the results of a Russian retrospective multicenter study on the use of incobotulinumtoxinA for the treatment of spasticity and sialorrhea in CP, data from recently published international clinical trials, and our own clinical experience. We present detailed practical recommendations on the calculation of the total dose of incobotulinumtoxinA per procedure for the treatment of spasticity in CP, on the calculation of incobotulinumtoxinA dose for the most common target muscles (lower and upper limbs) for spasticity treatment in CP, on incobotulinumtoxinA dilution and dose calculation for sialorrhea treatment in children, on incobotulinumtoxinA dilution and dose calculation for simultaneous treatment of spasticity and sialorrhea in CP. We justify incobotulinumtoxinA use, when simultaneous treatment of spasticity and sialorrhea is necessary, which allows reducing the intervals between repeated injection cycles. IncobotulinumtoxinA use in children with CP demonstrates a favorable safety profile, including long-term use.https://nnp.ima-press.net/nnp/article/view/1795cerebral palsybotulinum therapyincobotulinumtoxinalower limbs spasticityupper limbs spasticitysialorrheatotal dose |
| spellingShingle | A. L. Kurenkov L. M. Kuzenkova B. I. Bursagova V. V. Chernikov O. V. Agranovich L. G. Khachatryan V. M. Kenis V. A. Zherebtsova M. N. Sarzhina N. D. Odinaeva A. R. Artemenko G. A. Popova E. A. Moroshek E. E. Tabe A. A. Nezhelskaya A. A. Maksimenko L. Ya. Akhadova M. V. Indereikin N. V. Duibanova L. V. Tikhonova A. V. Sapogovskiy Z. M. Gadzhialieva A. V. Grigorieva V. S. Perminov I. D. Fedonyuk L. M. Kolpakchi A. Yu. Kursakova N. A. Tsurina Russian consensus on the use of incobotulinumtoxinA in children with cerebral palsy for the treatment of spasticity and sialorrhea Неврология, нейропсихиатрия, психосоматика cerebral palsy botulinum therapy incobotulinumtoxina lower limbs spasticity upper limbs spasticity sialorrhea total dose |
| title | Russian consensus on the use of incobotulinumtoxinA in children with cerebral palsy for the treatment of spasticity and sialorrhea |
| title_full | Russian consensus on the use of incobotulinumtoxinA in children with cerebral palsy for the treatment of spasticity and sialorrhea |
| title_fullStr | Russian consensus on the use of incobotulinumtoxinA in children with cerebral palsy for the treatment of spasticity and sialorrhea |
| title_full_unstemmed | Russian consensus on the use of incobotulinumtoxinA in children with cerebral palsy for the treatment of spasticity and sialorrhea |
| title_short | Russian consensus on the use of incobotulinumtoxinA in children with cerebral palsy for the treatment of spasticity and sialorrhea |
| title_sort | russian consensus on the use of incobotulinumtoxina in children with cerebral palsy for the treatment of spasticity and sialorrhea |
| topic | cerebral palsy botulinum therapy incobotulinumtoxina lower limbs spasticity upper limbs spasticity sialorrhea total dose |
| url | https://nnp.ima-press.net/nnp/article/view/1795 |
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