Effect of hypoxia on extracellular vesicles in malignant and non-malignant conditions
Extracellular vesicles (EVs) are produced by virtually all types of cells and can be detected in nearly all extracellular places. These particles mediate intercellular communication and transfer their cargo to the recipient cells, inducing a variety of processes in these cells through transmission o...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Cancer Treatment and Research Communications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294225000619 |
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| author | Vahid Niazi Soudeh Ghafouri-Fard |
| author_facet | Vahid Niazi Soudeh Ghafouri-Fard |
| author_sort | Vahid Niazi |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are produced by virtually all types of cells and can be detected in nearly all extracellular places. These particles mediate intercellular communication and transfer their cargo to the recipient cells, inducing a variety of processes in these cells through transmission of several biomolecules such as miRNAs, lncRNAs, other transcripts and a variety of proteins. It has been documented that size, quantity, and expression of biomolecules in the EVs are influenced by the level of oxygen. In fact, hypoxia can affect several cellular processes through modulation of the cargo of these vesicles. Hypoxic exosomes derived from tumor cells have several protumoral effects on the recipient cells, including enhancement of proliferation, migration, and invasion in other tumoral cells, induction of metastasis in distant organs, stimulation of angiogenesis in the endothelial cells, and modulation of macrophage polarization. Hypoxic EVs also contribute to several non-malignant diseases. This review summarizes the effect of hypoxia on EVs cargo in malignant and nonmalignant diseases of different organs. |
| format | Article |
| id | doaj-art-9d05aeabe5a44843948e2b2e24225d06 |
| institution | OA Journals |
| issn | 2468-2942 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj-art-9d05aeabe5a44843948e2b2e24225d062025-08-20T02:11:26ZengElsevierCancer Treatment and Research Communications2468-29422025-01-014310092410.1016/j.ctarc.2025.100924Effect of hypoxia on extracellular vesicles in malignant and non-malignant conditionsVahid Niazi0Soudeh Ghafouri-Fard1Stem Cell Research Center, Golestan University of Medical Science, Gorgan, Iran; School of Advanced Technologies in Medicine, Golestan University of Medical Science, Gorgan, IranDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author.Extracellular vesicles (EVs) are produced by virtually all types of cells and can be detected in nearly all extracellular places. These particles mediate intercellular communication and transfer their cargo to the recipient cells, inducing a variety of processes in these cells through transmission of several biomolecules such as miRNAs, lncRNAs, other transcripts and a variety of proteins. It has been documented that size, quantity, and expression of biomolecules in the EVs are influenced by the level of oxygen. In fact, hypoxia can affect several cellular processes through modulation of the cargo of these vesicles. Hypoxic exosomes derived from tumor cells have several protumoral effects on the recipient cells, including enhancement of proliferation, migration, and invasion in other tumoral cells, induction of metastasis in distant organs, stimulation of angiogenesis in the endothelial cells, and modulation of macrophage polarization. Hypoxic EVs also contribute to several non-malignant diseases. This review summarizes the effect of hypoxia on EVs cargo in malignant and nonmalignant diseases of different organs.http://www.sciencedirect.com/science/article/pii/S2468294225000619Extracellular vesicleExosomeCancerHypoxia |
| spellingShingle | Vahid Niazi Soudeh Ghafouri-Fard Effect of hypoxia on extracellular vesicles in malignant and non-malignant conditions Cancer Treatment and Research Communications Extracellular vesicle Exosome Cancer Hypoxia |
| title | Effect of hypoxia on extracellular vesicles in malignant and non-malignant conditions |
| title_full | Effect of hypoxia on extracellular vesicles in malignant and non-malignant conditions |
| title_fullStr | Effect of hypoxia on extracellular vesicles in malignant and non-malignant conditions |
| title_full_unstemmed | Effect of hypoxia on extracellular vesicles in malignant and non-malignant conditions |
| title_short | Effect of hypoxia on extracellular vesicles in malignant and non-malignant conditions |
| title_sort | effect of hypoxia on extracellular vesicles in malignant and non malignant conditions |
| topic | Extracellular vesicle Exosome Cancer Hypoxia |
| url | http://www.sciencedirect.com/science/article/pii/S2468294225000619 |
| work_keys_str_mv | AT vahidniazi effectofhypoxiaonextracellularvesiclesinmalignantandnonmalignantconditions AT soudehghafourifard effectofhypoxiaonextracellularvesiclesinmalignantandnonmalignantconditions |