The prognostic efficacy and improvements of the 7th edition Union for International Cancer Control tumor–node–metastasis classifications for Chinese patients with gastric cancer: Results based on a retrospective three-decade population study
This study aimed to evaluate survival trends for patients with gastric cancer in northeast China in the most recent three decades and analyze the applicability of the UICC tumor-node-metastasis (TNM) classification 7th edition for Chinese patients with gastric cancer. A review of all inpatient and o...
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| Language: | English |
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SAGE Publishing
2017-03-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317694548 |
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| author | Huizi Gu Dongmei Li Haitao Zhu Hao Zhang Ying Yu Dongxue Qin Mei Yi Xiang Li Ping Lu |
| author_facet | Huizi Gu Dongmei Li Haitao Zhu Hao Zhang Ying Yu Dongxue Qin Mei Yi Xiang Li Ping Lu |
| author_sort | Huizi Gu |
| collection | DOAJ |
| description | This study aimed to evaluate survival trends for patients with gastric cancer in northeast China in the most recent three decades and analyze the applicability of the UICC tumor-node-metastasis (TNM) classification 7th edition for Chinese patients with gastric cancer. A review of all inpatient and outpatient records of patients with gastric cancer was conducted in the first hospital of China Medical University and the Liaoning Cancer Hospital and Institute. All patients who met the inclusion criteria and were seen from January 1980 through December 2009 were included in the study. The primary outcome was 5-year survival, which was analyzed according to decade of diagnosis and TNM classifications. From 1980 through 2009, the 5-year survival rates for patients with gastric cancer (n=2414) increased from 39.1% to 57.3%. Decade of diagnosis was significantly associated with patient survival (p = 0.013), and the 5-year survival rate in the 2000s was remarkably higher than that in the 1980s and 1990s (p = 0.004 and 0.049, respectively). When classified according to the UICC TNM classification of gastric cancer 7th edition, the prognoses of stage IIIA and stage IIIB patients were not significantly different (p = 0.077). However, if stage T4b and stage N0 patients were classified as stage IIIA, the prognoses of stage IIIA and stage IIIB patients were significantly different (p < 0.001). Hence, there was a significant difference in survival during the three time periods in Northeast China. Classifying stage T4b and stage N0 patients as stage IIIA according to the 7th edition of UICC gastric cancer TNM classifications better stratified Chinese patients and predicted prognoses. |
| format | Article |
| id | doaj-art-9cfffa8191ba424696d2f4398767ff7f |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-9cfffa8191ba424696d2f4398767ff7f2025-08-20T03:37:02ZengSAGE PublishingTumor Biology1423-03802017-03-013910.1177/1010428317694548The prognostic efficacy and improvements of the 7th edition Union for International Cancer Control tumor–node–metastasis classifications for Chinese patients with gastric cancer: Results based on a retrospective three-decade population studyHuizi Gu0Dongmei Li1Haitao Zhu2Hao Zhang3Ying Yu4Dongxue Qin5Mei Yi6Xiang Li7Ping Lu8Department of Internal Neurology, The Second Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, Dalian Hospital of Traditional Chinese Medicine, Dalian, ChinaDepartment of Gastric Surgery, Liaoning Cancer Hospital and Institute, Shenyang, ChinaBreast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, The Second Hospital of Dalian Medical University, Dalian, ChinaLiaoning Medical Device Test Institute, Shenyang, ChinaDepartment of Radiology, The Second Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The Second Hospital of Dalian Medical University, Dalian, ChinaDepartment of Radiology, The Second Hospital of Dalian Medical University, Dalian, ChinaDepartment of Surgical Oncology, The First Hospital of China Medical University, Shenyang, ChinaThis study aimed to evaluate survival trends for patients with gastric cancer in northeast China in the most recent three decades and analyze the applicability of the UICC tumor-node-metastasis (TNM) classification 7th edition for Chinese patients with gastric cancer. A review of all inpatient and outpatient records of patients with gastric cancer was conducted in the first hospital of China Medical University and the Liaoning Cancer Hospital and Institute. All patients who met the inclusion criteria and were seen from January 1980 through December 2009 were included in the study. The primary outcome was 5-year survival, which was analyzed according to decade of diagnosis and TNM classifications. From 1980 through 2009, the 5-year survival rates for patients with gastric cancer (n=2414) increased from 39.1% to 57.3%. Decade of diagnosis was significantly associated with patient survival (p = 0.013), and the 5-year survival rate in the 2000s was remarkably higher than that in the 1980s and 1990s (p = 0.004 and 0.049, respectively). When classified according to the UICC TNM classification of gastric cancer 7th edition, the prognoses of stage IIIA and stage IIIB patients were not significantly different (p = 0.077). However, if stage T4b and stage N0 patients were classified as stage IIIA, the prognoses of stage IIIA and stage IIIB patients were significantly different (p < 0.001). Hence, there was a significant difference in survival during the three time periods in Northeast China. Classifying stage T4b and stage N0 patients as stage IIIA according to the 7th edition of UICC gastric cancer TNM classifications better stratified Chinese patients and predicted prognoses.https://doi.org/10.1177/1010428317694548 |
| spellingShingle | Huizi Gu Dongmei Li Haitao Zhu Hao Zhang Ying Yu Dongxue Qin Mei Yi Xiang Li Ping Lu The prognostic efficacy and improvements of the 7th edition Union for International Cancer Control tumor–node–metastasis classifications for Chinese patients with gastric cancer: Results based on a retrospective three-decade population study Tumor Biology |
| title | The prognostic efficacy and improvements of the 7th edition Union for International Cancer Control tumor–node–metastasis classifications for Chinese patients with gastric cancer: Results based on a retrospective three-decade population study |
| title_full | The prognostic efficacy and improvements of the 7th edition Union for International Cancer Control tumor–node–metastasis classifications for Chinese patients with gastric cancer: Results based on a retrospective three-decade population study |
| title_fullStr | The prognostic efficacy and improvements of the 7th edition Union for International Cancer Control tumor–node–metastasis classifications for Chinese patients with gastric cancer: Results based on a retrospective three-decade population study |
| title_full_unstemmed | The prognostic efficacy and improvements of the 7th edition Union for International Cancer Control tumor–node–metastasis classifications for Chinese patients with gastric cancer: Results based on a retrospective three-decade population study |
| title_short | The prognostic efficacy and improvements of the 7th edition Union for International Cancer Control tumor–node–metastasis classifications for Chinese patients with gastric cancer: Results based on a retrospective three-decade population study |
| title_sort | prognostic efficacy and improvements of the 7th edition union for international cancer control tumor node metastasis classifications for chinese patients with gastric cancer results based on a retrospective three decade population study |
| url | https://doi.org/10.1177/1010428317694548 |
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