Leukocyte telomere length serves as the novel prognostic biomarker for the resectable NSCLC
Abstract The relationship of Leukocyte telomere length (LTL) dynamic changes with resectable NSCLC progression remains unclear. This study aims to reveal its clinical utility for prognosis of the resectable NSCLC. LTL was measured in 76 resectable NSCLC patients and 80 healthy controls using periphe...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-04-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-95569-8 |
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| author | Guanxuan Chen Shiwen Wang Xinkai Mo Wanqi Zhu Ruoyu Wang Xingguo Song |
| author_facet | Guanxuan Chen Shiwen Wang Xinkai Mo Wanqi Zhu Ruoyu Wang Xingguo Song |
| author_sort | Guanxuan Chen |
| collection | DOAJ |
| description | Abstract The relationship of Leukocyte telomere length (LTL) dynamic changes with resectable NSCLC progression remains unclear. This study aims to reveal its clinical utility for prognosis of the resectable NSCLC. LTL was measured in 76 resectable NSCLC patients and 80 healthy controls using peripheral blood samples. Pre-operation LTL (Pre-LTL) and post-operation LTL (Po-LTL) were analyzed in relation to TNM stage, metastasis, and survival outcomes. The prognostic value was evaluated by disease-free survival (DFS) and overall survival (OS). NSCLC patients had significantly shorter LTL compared to controls, with LTL inversely correlated to disease stage. Po-LTL increased significantly and was associated with better OS. Combining Po-LTL with TNM stage improved prognostic prediction for OS and DFS. LTL is a promising biomarker for predicting prognosis in resectable NSCLC. Po-LTL, as well as in combination with TNM stage, enhances predictive accuracy for OS and DFS. |
| format | Article |
| id | doaj-art-9cffd9b1177d45dda746b4d5887dd0a5 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-9cffd9b1177d45dda746b4d5887dd0a52025-08-20T02:17:47ZengNature PortfolioScientific Reports2045-23222025-04-0115111110.1038/s41598-025-95569-8Leukocyte telomere length serves as the novel prognostic biomarker for the resectable NSCLCGuanxuan Chen0Shiwen Wang1Xinkai Mo2Wanqi Zhu3Ruoyu Wang4Xingguo Song5Oncology Department, Affiliated Zhongshan Hospital of Dalian UniversityDepartment of Clinical Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical SciencesDepartment of Clinical Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical SciencesShandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical SciencesOncology Department, Affiliated Zhongshan Hospital of Dalian UniversityDepartment of Clinical Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical SciencesAbstract The relationship of Leukocyte telomere length (LTL) dynamic changes with resectable NSCLC progression remains unclear. This study aims to reveal its clinical utility for prognosis of the resectable NSCLC. LTL was measured in 76 resectable NSCLC patients and 80 healthy controls using peripheral blood samples. Pre-operation LTL (Pre-LTL) and post-operation LTL (Po-LTL) were analyzed in relation to TNM stage, metastasis, and survival outcomes. The prognostic value was evaluated by disease-free survival (DFS) and overall survival (OS). NSCLC patients had significantly shorter LTL compared to controls, with LTL inversely correlated to disease stage. Po-LTL increased significantly and was associated with better OS. Combining Po-LTL with TNM stage improved prognostic prediction for OS and DFS. LTL is a promising biomarker for predicting prognosis in resectable NSCLC. Po-LTL, as well as in combination with TNM stage, enhances predictive accuracy for OS and DFS.https://doi.org/10.1038/s41598-025-95569-8Leukocyte telomere length (LTL)Resectable NSCLCPrognosisBiomarkerTelomerase reverse transcriptase (TERT) |
| spellingShingle | Guanxuan Chen Shiwen Wang Xinkai Mo Wanqi Zhu Ruoyu Wang Xingguo Song Leukocyte telomere length serves as the novel prognostic biomarker for the resectable NSCLC Scientific Reports Leukocyte telomere length (LTL) Resectable NSCLC Prognosis Biomarker Telomerase reverse transcriptase (TERT) |
| title | Leukocyte telomere length serves as the novel prognostic biomarker for the resectable NSCLC |
| title_full | Leukocyte telomere length serves as the novel prognostic biomarker for the resectable NSCLC |
| title_fullStr | Leukocyte telomere length serves as the novel prognostic biomarker for the resectable NSCLC |
| title_full_unstemmed | Leukocyte telomere length serves as the novel prognostic biomarker for the resectable NSCLC |
| title_short | Leukocyte telomere length serves as the novel prognostic biomarker for the resectable NSCLC |
| title_sort | leukocyte telomere length serves as the novel prognostic biomarker for the resectable nsclc |
| topic | Leukocyte telomere length (LTL) Resectable NSCLC Prognosis Biomarker Telomerase reverse transcriptase (TERT) |
| url | https://doi.org/10.1038/s41598-025-95569-8 |
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