Age and primary vaccination schedule impact humoral and cellular immunity with an inactivated SARS-CoV-2 vaccine

Age and primary vaccination schedule impact humoral and cellular immunity with an inactivated SARS-CoV-2 vaccine

Summary: Despite widespread COVID-19 vaccination, questions remain about vaccine safety and immunogenicity in vulnerable populations, such as older adults. We evaluated the safety and immunogenicity of four doses of CoronaVac in adults above and below 60 who received the first two doses in two diffe...

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Main Authors: Yohana Martínez-Balboa, Linmar Rodríguez-Guilarte, Constanza Méndez, Mariana Ríos, Daniela B. Rivera, Daniela Moreno-Tapia, Humberto A. Reyes, Patricia Pereira-Sánchez, Claudia Orellana, Alex Cabrera, Bárbara M. Schultz, Luisa F. Duarte, Nicolás M.S. Gálvez, Felipe Melo-González, Jorge A. Soto, Carolina Iturriaga, Marcela Urzúa, María S. Navarrete, Álvaro Rojas, Rodrigo A. Fasce, Jorge Fernández, Judith Mora, Eugenio Ramírez, Daniela Weiskopf, Alba Grifoni, Alessandro Sette, Gang Zeng, Weining Meng, María Javiera Alvarez-Figueroa, José V. González-Aramundiz, M. Angélica Domínguez, Pablo A. González, Katia Abarca, Hernán F. Peñaloza, Susan M. Bueno, Alexis M. Kalergis
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Immune response
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225014282
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