Porphyromonas gingivalis OMVs inhibit osteogenic differentiation of BMSCs via SAA3/TLR4/MyD88/NF-κB axis

Porphyromonas gingivalis OMVs inhibit osteogenic differentiation of BMSCs via SAA3/TLR4/MyD88/NF-κB axis

Backgrounds Periodontitis-induced alveolar bone loss is a primary cause of tooth loss. Porphyromonas gingivalis (P. gingivalis) is the primary pathogenic bacterium of periodontitis. Outer membrane vesicles (OMVs) derived from P. gingivalis (P.g-OMVs) contain various bioactive molecules, and several...

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Bibliographic Details
Main Authors: Yongyong Yan, Haiyan Wang, Huizhi Deng, Haokun He, Qing Ge, Jun Zha, Jun Chen, Qing Zhang, Haiyan Deng, Gang Wu, Richard T. Jaspers, Janak L. Pathak
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Journal of Oral Microbiology
Subjects:
P. gingivalis
outer membrane vesicles
serum amyloid a
osteoblast differentiation
BMSCs
Periodontitis
Online Access:https://www.tandfonline.com/doi/10.1080/20002297.2025.2540823
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