The effects of inorganic nitrate and inulin co-ingestion on circulating metabolites and blood pressure in young adults: a pilot double-blind randomised crossover trial
Dietary patterns enriched in fermentable fibre (such as inulin) and inorganic nitrate are linked to cardiovascular benefits, possibly mediated by gut microbiota-derived bioactive compounds including short-chain fatty acids (SCFAs) and nitric oxide (NO). However, the potential synergistic effects rem...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2025-01-01
|
| Series: | Gut Microbiome |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S263228972510008X/type/journal_article |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Dietary patterns enriched in fermentable fibre (such as inulin) and inorganic nitrate are linked to cardiovascular benefits, possibly mediated by gut microbiota-derived bioactive compounds including short-chain fatty acids (SCFAs) and nitric oxide (NO). However, the potential synergistic effects remain unclear. We conducted a randomised, double-blind, crossover study to investigate the acute effects of inulin (15 g; INU), nitrate (400 mg; NO3−), and their combination (INU + NO3−) on plasma nitrate and nitrite levels, SCFAs, and blood pressure (BP) in 20 adults. Plasma nitrate and nitrite were significantly elevated following INU + NO3− and NO3− compared to INU (p < 0.001). Plasma SCFAs were increased after INU + NO3− and INU, but the incremental AUC was not statistically significant, likely due to large inter-individual variability. No significant main effects were observed on BP; however, inverse correlations were identified between peak plasma nitrite and diastolic BP (rs = −0.61, p = 0.004) and mean arterial pressure (MAP) (rs = −0.59, p = 0.005) following INU + NO3−. Peak nitrate concentrations were inversely correlated with diastolic BP following NO3− (rs = −0.47, p = 0.004). Co-supplementation with inulin and nitrate did not enhance plasma nitrate/nitrite or BP beyond nitrate alone but modulated SCFA profiles, suggesting potential interactions between fibre fermentation and nitrate metabolism for cardiovascular health. |
|---|---|
| ISSN: | 2632-2897 |