Antibiotic-Resistant <i>Pseudomonas aeruginosa</i>: Current Challenges and Emerging Alternative Therapies
Antibiotic-resistant <i>Pseudomonas aeruginosa</i> is a pathogen notorious for its resilience in clinical settings due to biofilm formation, efflux pumps, and the rapid acquisition of resistance genes. With traditional antibiotic therapy rendered ineffective against <i>Pseudomonas...
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MDPI AG
2025-04-01
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| author | Minqi Hu Song Lin Chua |
| author_facet | Minqi Hu Song Lin Chua |
| author_sort | Minqi Hu |
| collection | DOAJ |
| description | Antibiotic-resistant <i>Pseudomonas aeruginosa</i> is a pathogen notorious for its resilience in clinical settings due to biofilm formation, efflux pumps, and the rapid acquisition of resistance genes. With traditional antibiotic therapy rendered ineffective against <i>Pseudomonas aeruginosa</i> infections, we explore alternative therapies that have shown promise, including antimicrobial peptides, nanoparticles and quorum sensing inhibitors. While these approaches offer potential, they each face challenges, such as specificity, stability, and delivery, which require careful consideration and further study. We also delve into emerging alternative strategies, such as bacteriophage therapy and CRISPR-Cas gene editing that could enhance targeted treatment for personalized medicine. As most of them are currently in experimental stages, we highlight the need for clinical trials and additional research to confirm their feasibility. Hence, we offer insights into new therapeutic avenues that could help address the pressing issue of antibiotic-resistant <i>Pseudomonas aeruginosa</i>, with an eye toward practical applications in future healthcare. |
| format | Article |
| id | doaj-art-9cf637889cee400b9934b8daea3d4698 |
| institution | OA Journals |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-9cf637889cee400b9934b8daea3d46982025-08-20T02:18:04ZengMDPI AGMicroorganisms2076-26072025-04-0113491310.3390/microorganisms13040913Antibiotic-Resistant <i>Pseudomonas aeruginosa</i>: Current Challenges and Emerging Alternative TherapiesMinqi Hu0Song Lin Chua1Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, ChinaDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, ChinaAntibiotic-resistant <i>Pseudomonas aeruginosa</i> is a pathogen notorious for its resilience in clinical settings due to biofilm formation, efflux pumps, and the rapid acquisition of resistance genes. With traditional antibiotic therapy rendered ineffective against <i>Pseudomonas aeruginosa</i> infections, we explore alternative therapies that have shown promise, including antimicrobial peptides, nanoparticles and quorum sensing inhibitors. While these approaches offer potential, they each face challenges, such as specificity, stability, and delivery, which require careful consideration and further study. We also delve into emerging alternative strategies, such as bacteriophage therapy and CRISPR-Cas gene editing that could enhance targeted treatment for personalized medicine. As most of them are currently in experimental stages, we highlight the need for clinical trials and additional research to confirm their feasibility. Hence, we offer insights into new therapeutic avenues that could help address the pressing issue of antibiotic-resistant <i>Pseudomonas aeruginosa</i>, with an eye toward practical applications in future healthcare.https://www.mdpi.com/2076-2607/13/4/913<i>Pseudomonas aeruginosa</i>antibiotic resistancebacteriophagenanoparticleantimicrobial peptidesCRISPR |
| spellingShingle | Minqi Hu Song Lin Chua Antibiotic-Resistant <i>Pseudomonas aeruginosa</i>: Current Challenges and Emerging Alternative Therapies Microorganisms <i>Pseudomonas aeruginosa</i> antibiotic resistance bacteriophage nanoparticle antimicrobial peptides CRISPR |
| title | Antibiotic-Resistant <i>Pseudomonas aeruginosa</i>: Current Challenges and Emerging Alternative Therapies |
| title_full | Antibiotic-Resistant <i>Pseudomonas aeruginosa</i>: Current Challenges and Emerging Alternative Therapies |
| title_fullStr | Antibiotic-Resistant <i>Pseudomonas aeruginosa</i>: Current Challenges and Emerging Alternative Therapies |
| title_full_unstemmed | Antibiotic-Resistant <i>Pseudomonas aeruginosa</i>: Current Challenges and Emerging Alternative Therapies |
| title_short | Antibiotic-Resistant <i>Pseudomonas aeruginosa</i>: Current Challenges and Emerging Alternative Therapies |
| title_sort | antibiotic resistant i pseudomonas aeruginosa i current challenges and emerging alternative therapies |
| topic | <i>Pseudomonas aeruginosa</i> antibiotic resistance bacteriophage nanoparticle antimicrobial peptides CRISPR |
| url | https://www.mdpi.com/2076-2607/13/4/913 |
| work_keys_str_mv | AT minqihu antibioticresistantipseudomonasaeruginosaicurrentchallengesandemergingalternativetherapies AT songlinchua antibioticresistantipseudomonasaeruginosaicurrentchallengesandemergingalternativetherapies |