The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy

The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy

Summary: The pre-mRNA processing factor 4 kinase (PRP4K) is an essential gene in animal cells, making interrogation of its function challenging. Here, we report characterization of a viable knockout model of PRP4K in the social amoeba Dictyostelium discoideum, revealing a function for PRP4K in splic...

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Bibliographic Details
Main Authors: Sabateeshan Mathavarajah, Sandhya Chipurupalli, Elias B. Habib, William D. Kim, Megan M. Aoki, Dale P. Corkery, Kennedy I.T. Whelan, Jordan Lukacs, Melis Erkan, Victor D. Martinez, Kevin S. Smith, Stephen B. Montgomery, Jayme Salsman, Robert J. Huber, Graham Dellaire
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Cell biology
CP: Developmental biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725006412
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