Probiotic administration correlated with reduced diarrheal incidence and improved gut microbiota diversity in young goats
IntroductionProbiotic interventions in young livestock are gaining attention for their potential health benefits.MethodsThis study involved 15 weaned goat kids (2–3 months old; 10–15 kg body weight), including 10 healthy kids and 5 diarrheic kids. The kids were divided into three groups: Healthy Con...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2025.1604638/full |
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| author | Mohamed Osman Abdalrahem Essa Mohamed Osman Abdalrahem Essa Cheng Cheng Jun Li Xiao Han Zhong Kang Wei Layla Ahmed Mohammed Abdelhadi Huda Ahmed Hassan Saber Y. Adam Hosameldeen Mohamed Husien Hosameldeen Mohamed Husien Ahmed A. Saleh Ahmed A. Saleh Darong Cheng Darong Cheng |
| author_facet | Mohamed Osman Abdalrahem Essa Mohamed Osman Abdalrahem Essa Cheng Cheng Jun Li Xiao Han Zhong Kang Wei Layla Ahmed Mohammed Abdelhadi Huda Ahmed Hassan Saber Y. Adam Hosameldeen Mohamed Husien Hosameldeen Mohamed Husien Ahmed A. Saleh Ahmed A. Saleh Darong Cheng Darong Cheng |
| author_sort | Mohamed Osman Abdalrahem Essa |
| collection | DOAJ |
| description | IntroductionProbiotic interventions in young livestock are gaining attention for their potential health benefits.MethodsThis study involved 15 weaned goat kids (2–3 months old; 10–15 kg body weight), including 10 healthy kids and 5 diarrheic kids. The kids were divided into three groups: Healthy Control (H, no treatment), Probiotic-Treated Healthy (T), and Diarrheic + Probiotic-Treated (D). All kids were maintained under standardized environmental conditions and fed a controlled diet (60% corn, 15% pea skin, 15% silage, 5% hay and 1% vitamin-mineral additives). Probiotic bacteria Enterococcus faecium and Bacteroides fragilis were administered via oral gavage at a concentration of (1 × 109) CFU/mL for five consecutive days. Fecal samples were collected for sequencing of the bacterial 16S rRNA gene to analyze microbial composition.ResultsHealthy groups exhibited significantly greater species richness and diversity compared to the diarrheal group (p < 0.01). The predominant phyla identified were Pseudomonadota, Bacteroidetes, and Bacillota.Increased levels of Xylanibacter, UCG-055, Bacteroides, and Escherichia-Shigella were noted in healthy treated kids, while Prevotellaceae UG_001 and Proteus decreased.DiscussionThe findings highlight significant gut microbiota differences between healthy and diarrheal kids, suggesting that modifications in gut microbiota composition could alleviate diarrhea, contributing to preventive and therapeutic strategies for this condition. |
| format | Article |
| id | doaj-art-9cf2c05eec994c15b473a6fff91b65e4 |
| institution | DOAJ |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-9cf2c05eec994c15b473a6fff91b65e42025-08-20T02:40:29ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-06-011210.3389/fvets.2025.16046381604638Probiotic administration correlated with reduced diarrheal incidence and improved gut microbiota diversity in young goatsMohamed Osman Abdalrahem Essa0Mohamed Osman Abdalrahem Essa1Cheng Cheng2Jun Li3Xiao Han4Zhong Kang Wei5Layla Ahmed Mohammed Abdelhadi6Huda Ahmed Hassan7Saber Y. Adam8Hosameldeen Mohamed Husien9Hosameldeen Mohamed Husien10Ahmed A. Saleh11Ahmed A. Saleh12Darong Cheng13Darong Cheng14College of Veterinary Medicine, Yangzhou University, Yangzhou, ChinaCollege of Veterinary Medicine, Albutana University, Rufaa, SudanCollege of Veterinary Medicine, Yangzhou University, Yangzhou, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou, ChinaCollege of Veterinary Medicine, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Veterinary Medicine, Albutana University, Rufaa, SudanCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaAnimal and Fish Production Department, Faculty of Agriculture (Al-Shatby), Alexandria University, Alexandria, EgyptCollege of Veterinary Medicine, Yangzhou University, Yangzhou, ChinaJiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, ChinaIntroductionProbiotic interventions in young livestock are gaining attention for their potential health benefits.MethodsThis study involved 15 weaned goat kids (2–3 months old; 10–15 kg body weight), including 10 healthy kids and 5 diarrheic kids. The kids were divided into three groups: Healthy Control (H, no treatment), Probiotic-Treated Healthy (T), and Diarrheic + Probiotic-Treated (D). All kids were maintained under standardized environmental conditions and fed a controlled diet (60% corn, 15% pea skin, 15% silage, 5% hay and 1% vitamin-mineral additives). Probiotic bacteria Enterococcus faecium and Bacteroides fragilis were administered via oral gavage at a concentration of (1 × 109) CFU/mL for five consecutive days. Fecal samples were collected for sequencing of the bacterial 16S rRNA gene to analyze microbial composition.ResultsHealthy groups exhibited significantly greater species richness and diversity compared to the diarrheal group (p < 0.01). The predominant phyla identified were Pseudomonadota, Bacteroidetes, and Bacillota.Increased levels of Xylanibacter, UCG-055, Bacteroides, and Escherichia-Shigella were noted in healthy treated kids, while Prevotellaceae UG_001 and Proteus decreased.DiscussionThe findings highlight significant gut microbiota differences between healthy and diarrheal kids, suggesting that modifications in gut microbiota composition could alleviate diarrhea, contributing to preventive and therapeutic strategies for this condition.https://www.frontiersin.org/articles/10.3389/fvets.2025.1604638/fullgoat kidsprobioticsgut microbiotadiarrheaEnterococcus faeciumBacteroides fragilis |
| spellingShingle | Mohamed Osman Abdalrahem Essa Mohamed Osman Abdalrahem Essa Cheng Cheng Jun Li Xiao Han Zhong Kang Wei Layla Ahmed Mohammed Abdelhadi Huda Ahmed Hassan Saber Y. Adam Hosameldeen Mohamed Husien Hosameldeen Mohamed Husien Ahmed A. Saleh Ahmed A. Saleh Darong Cheng Darong Cheng Probiotic administration correlated with reduced diarrheal incidence and improved gut microbiota diversity in young goats Frontiers in Veterinary Science goat kids probiotics gut microbiota diarrhea Enterococcus faecium Bacteroides fragilis |
| title | Probiotic administration correlated with reduced diarrheal incidence and improved gut microbiota diversity in young goats |
| title_full | Probiotic administration correlated with reduced diarrheal incidence and improved gut microbiota diversity in young goats |
| title_fullStr | Probiotic administration correlated with reduced diarrheal incidence and improved gut microbiota diversity in young goats |
| title_full_unstemmed | Probiotic administration correlated with reduced diarrheal incidence and improved gut microbiota diversity in young goats |
| title_short | Probiotic administration correlated with reduced diarrheal incidence and improved gut microbiota diversity in young goats |
| title_sort | probiotic administration correlated with reduced diarrheal incidence and improved gut microbiota diversity in young goats |
| topic | goat kids probiotics gut microbiota diarrhea Enterococcus faecium Bacteroides fragilis |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2025.1604638/full |
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