Two mutually complementary synthetic approaches towards 3-substituted 3,4-disubstituted and 1-(2-pyridyl)-substituted isoquinolines
Two mutually complementary synthetic approaches towards 3- and 3,4-disubstituted 1-(2-pyridyl) isoquinolines were studied. The aryne-based method was successfully used for the obtaining of the corresponding the 3-cyano-1-(2-pyridyl)isoquinolines in one step/pot reaction, while it is unacceptable for...
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| Format: | Article |
| Language: | English |
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Ural Federal University
2018-10-01
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| Series: | Chimica Techno Acta |
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| Online Access: | https://chimicatechnoacta.ru/article/view/3462 |
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| author | I. L. Nikonov D. S. Kopchuk A. F. Khasanov A. P. Krinochkin E. S. Starnovskaya Ya. K. Shtaiz M. I. Savchuk O. S. Tanya G. V. Zyryanov V. L. Rusinov O. N. Chupakhin |
| author_facet | I. L. Nikonov D. S. Kopchuk A. F. Khasanov A. P. Krinochkin E. S. Starnovskaya Ya. K. Shtaiz M. I. Savchuk O. S. Tanya G. V. Zyryanov V. L. Rusinov O. N. Chupakhin |
| author_sort | I. L. Nikonov |
| collection | DOAJ |
| description | Two mutually complementary synthetic approaches towards 3- and 3,4-disubstituted 1-(2-pyridyl) isoquinolines were studied. The aryne-based method was successfully used for the obtaining of the corresponding the 3-cyano-1-(2-pyridyl)isoquinolines in one step/pot reaction, while it is unacceptable for the obtaining of other 1-(2-pyridyl)isoquinolines. The enamine-based approach was successfully applied for the synthesis of other 1-(2-pyridyl)isoquinolines, while it was unacceptable for the obtaining of 3-cyano-1-(2-pyridyl)isoquinolines. |
| format | Article |
| id | doaj-art-9cf1fc3f4b9741f7bca0f75e997761d2 |
| institution | OA Journals |
| issn | 2411-1414 |
| language | English |
| publishDate | 2018-10-01 |
| publisher | Ural Federal University |
| record_format | Article |
| series | Chimica Techno Acta |
| spelling | doaj-art-9cf1fc3f4b9741f7bca0f75e997761d22025-08-20T02:20:18ZengUral Federal UniversityChimica Techno Acta2411-14142018-10-015315015210.15826/chimtech.2018.5.3.042831Two mutually complementary synthetic approaches towards 3-substituted 3,4-disubstituted and 1-(2-pyridyl)-substituted isoquinolinesI. L. Nikonov0D. S. Kopchuk1A. F. Khasanov2A. P. Krinochkin3E. S. Starnovskaya4Ya. K. Shtaiz5M. I. Savchuk6O. S. Tanya7G. V. Zyryanov8V. L. Rusinov9O. N. Chupakhin10Ural Federal University, I. Ya. Postovskii Institute of Organic Synthesis, EkaterinburgUral Federal University, I. Ya. Postovskii Institute of Organic Synthesis, EkaterinburgUral Federal University, I. Ya. Postovskii Institute of Organic Synthesis, EkaterinburgUral Federal University, I. Ya. Postovskii Institute of Organic Synthesis, EkaterinburgUral Federal University, EkaterinburgUral Federal University, EkaterinburgUral Federal University, EkaterinburgUral Federal University, EkaterinburgUral Federal University, I. Ya. Postovskii Institute of Organic Synthesis, EkaterinburgUral Federal University, I. Ya. Postovskii Institute of Organic Synthesis, EkaterinburgUral Federal University, I. Ya. Postovskii Institute of Organic Synthesis, EkaterinburgTwo mutually complementary synthetic approaches towards 3- and 3,4-disubstituted 1-(2-pyridyl) isoquinolines were studied. The aryne-based method was successfully used for the obtaining of the corresponding the 3-cyano-1-(2-pyridyl)isoquinolines in one step/pot reaction, while it is unacceptable for the obtaining of other 1-(2-pyridyl)isoquinolines. The enamine-based approach was successfully applied for the synthesis of other 1-(2-pyridyl)isoquinolines, while it was unacceptable for the obtaining of 3-cyano-1-(2-pyridyl)isoquinolines.https://chimicatechnoacta.ru/article/view/34621,2,4-triazinesarynesenaminesisoqunolinesaza-diels-alder reactiondomino-transformation |
| spellingShingle | I. L. Nikonov D. S. Kopchuk A. F. Khasanov A. P. Krinochkin E. S. Starnovskaya Ya. K. Shtaiz M. I. Savchuk O. S. Tanya G. V. Zyryanov V. L. Rusinov O. N. Chupakhin Two mutually complementary synthetic approaches towards 3-substituted 3,4-disubstituted and 1-(2-pyridyl)-substituted isoquinolines Chimica Techno Acta 1,2,4-triazines arynes enamines isoqunolines aza-diels-alder reaction domino-transformation |
| title | Two mutually complementary synthetic approaches towards 3-substituted 3,4-disubstituted and 1-(2-pyridyl)-substituted isoquinolines |
| title_full | Two mutually complementary synthetic approaches towards 3-substituted 3,4-disubstituted and 1-(2-pyridyl)-substituted isoquinolines |
| title_fullStr | Two mutually complementary synthetic approaches towards 3-substituted 3,4-disubstituted and 1-(2-pyridyl)-substituted isoquinolines |
| title_full_unstemmed | Two mutually complementary synthetic approaches towards 3-substituted 3,4-disubstituted and 1-(2-pyridyl)-substituted isoquinolines |
| title_short | Two mutually complementary synthetic approaches towards 3-substituted 3,4-disubstituted and 1-(2-pyridyl)-substituted isoquinolines |
| title_sort | two mutually complementary synthetic approaches towards 3 substituted 3 4 disubstituted and 1 2 pyridyl substituted isoquinolines |
| topic | 1,2,4-triazines arynes enamines isoqunolines aza-diels-alder reaction domino-transformation |
| url | https://chimicatechnoacta.ru/article/view/3462 |
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