Fucosylated Glycosaminoglycan Oligosaccharide HS14, Derived from Sea Cucumbers, Is a Novel Inhibitor of Platelet Toll-like Receptor 2

Fucosylated Glycosaminoglycan Oligosaccharide HS14, Derived from Sea Cucumbers, Is a Novel Inhibitor of Platelet Toll-like Receptor 2

(1) Background: Toll-like receptor 2 (TLR2) on platelets is increasingly recognized as a pivotal mediator in infection-induced platelet activation and aggregation, contributing to both inflammatory and thrombotic diseases. Targeting TLR2 on platelets offers a promising therapeutic strategy for infla...

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Bibliographic Details
Main Authors: Huifang Sun, Guangyu Zhu, Sujuan Li, Pengfei Li, Jiali Zhang, Ronghua Yin, Lin Yuan, Na Gao, Jinhua Zhao
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Marine Drugs
Subjects:
toll-like receptor 2
platelet activation
platelet aggregation
platelet–granulocyte aggregates
fucosylated glycosaminoglycan
inflammatory diseases
Online Access:https://www.mdpi.com/1660-3397/23/3/110
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